171 results match your criteria: "Institute of Health System Science[Affiliation]"

: Positron emission tomography (PET) is a valuable tool for the assessment of lymphoma, while artificial intelligence (AI) holds promise as a reliable resource for the analysis of medical images. In this context, we systematically reviewed the applications of deep learning (DL) for the interpretation of lymphoma PET images. : We searched PubMed until 11 September 2024 for studies developing DL models for the evaluation of PET images of patients with lymphoma.

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Transitional care management (TCM) visits have been shown to reduce 30-day readmissions, but it is unclear whether the decrease arises from the TCM visit itself or from clinic-level changes to meet the requirements of the TCM visits. We conducted a cross-sectional analysis using data from Northwell Health to examine the association between the type of post-discharge follow-up visits (TCM visits versus non-TCM visits based on billing) and 30-day readmission. Furthermore, we assessed whether being seen by a provider who frequently utilizes TCM visits or the TCM visit itself was associated with 30-day readmission.

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This systematic review explores the association between herpes zoster (HZ) infection and Ogilvie's syndrome (acute colonic pseudo-obstruction), evaluating how varicella-zoster virus (VZV) reactivation may contribute to autonomic dysfunction leading to intestinal obstruction. A comprehensive search was conducted in PubMed, Scopus, and Cochrane Library databases up to October 2024, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible studies included case reports, clinical images, and letters reporting Ogilvie's syndrome secondary to HZ or VZV infection.

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Hemorrhage is a common postpartum complication which can also occur during abortion. Most cases can be managed with uterine evacuation and uterotonics, but some require additional procedures. We present cases of hemorrhage following dilation and evacuation, and delayed postpartum hemorrhage, where a Foley catheter was used for vacuum-induced hemorrhage control.

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Objectives: The All of Us Research Program harnesses advances in technology, science, and engagement for precision medicine research. We describe informatics innovations which support that goal and return value to the participant cohort and community.

Materials And Methods: Research data from the All of Us Research Program are available to authorized users on the All of Us Researcher Workbench.

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Executive and adaptive function impacts long-term outcomes for adults with maple syrup urine disease.

J Inherit Metab Dis

January 2025

Perelman School of Medicine at the University of Philadelphia, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Successful transition to independent adulthood requires intact executive and adaptive function. These neurocognitive domains are frequently impaired in inherited metabolic disorders (IMD), despite optimal management. For many IMDs, the impact of executive and adaptive dysfunction on long-term outcomes remains undefined.

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Objectives: This study aims to improve the ethical use of machine learning (ML)-based clinical prediction models (CPMs) in shared decision-making for patients with kidney failure on dialysis. We explore factors that inform acceptability, interpretability, and implementation of ML-based CPMs among multiple constituent groups.

Materials And Methods: We collected and analyzed qualitative data from focus groups with varied end users, including: dialysis support providers (clinical providers and additional dialysis support providers such as dialysis clinic staff and social workers); patients; patients' caregivers (n = 52).

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Efficacy of Interventions Intended to Increase Lung Cancer Screening Rates: A Systematic Review and Meta-analysis.

J Gen Intern Med

November 2024

Northwell Health, 2000 Marcus Ave., Suite 300, New Hyde Park, NY, 11042-1069, USA.

Background: Few eligible patients in the United States participate in lung cancer screening (LCS) with low-dose computed tomography (LDCT).

Objective: What is the efficacy of interventions to increase LCS participation?

Design: We performed a systematic review following a prespecified protocol registered in PROSPERO (CRD42021283984). In June/July of 2021, we searched Ovid MEDLINE, Embase, Cochrane, CENTRAL, ClinicalTrials.

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Older age is linked with poorer self-care in the chronic kidney disease (CKD) setting. Informal health supporters (family members and friends) are critical sources of self-care support, but much remains unclear about the characteristics and implications of received support among this patient population. We examined how received self-care support (amount and type) related to positive (CKD management self-efficacy) and negative (depressive symptoms) psychosocial health correlates of self-care in 536 adults aged 65 years and older with non-dialysis-dependent CKD.

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Clinical utility of anti-Müllerian hormone in female children and adolescents.

Hormones (Athens)

October 2024

Department of Obstetrics and Gynecology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, 45500, Greece.

Anti-Müllerian hormone (AMH) is a dimeric glycoprotein that belongs to the transforming growth factor beta superfamily and plays essential roles in sexual differentiation and folliculogenesis. In the male embryo, AMH is produced by the Sertoli cells and induces the involution of the Müllerian ducts. In females, AMH is predominately produced by the granulosa cells of growing preantral and small antral follicles and regulates follicular maturation.

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Study Objective: There is an increasing trend in myocardial infarction (MI) hospitalizations in young individuals. The prevalence of modifiable cardiovascular risk factors is high in this population. This study aims to assess the prevalence of traditional and non-traditional cardiovascular risk factors among young patients with coronary artery disease (CAD) including novel lipid and dietary biomarkers with a focus on potential gender differences.

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Article Synopsis
  • - Adequate sleep (7-9 hours per night) is vital for overall health, yet less than two-thirds of women achieve this, particularly during the COVID-19 pandemic, where healthcare workers (HCWs) faced significant stress and poor sleep quality.
  • - This study proposes a personalized (N-of-1) trial that evaluates the effectiveness of a mind-body intervention (MBI)—including mindfulness, yoga, and guided walking—over 16 weeks to improve sleep duration among women HCWs aged 40-60.
  • - The research will collect data on sleep, physiological factors, and relationships with stress, anxiety, and depression through daily check-ins and activity monitoring to develop tailored health interventions for middle-aged women.
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Oropharyngeal Dysphagia in Hospitalized Older Adults with Dementia: A Prospective Cohort Study.

J Am Med Dir Assoc

November 2024

Northwell, New Hyde Park, NY, USA; Department of Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell, Manhasset, NY, USA. Electronic address:

Article Synopsis
  • Oropharyngeal dysphagia is very common (up to 86%) in hospitalized patients with Alzheimer’s disease and related dementias (ADRD), prompting a study to understand its management and outcomes during hospital stays.* -
  • Conducted in New York across 10 hospitals, the study involved older adults with ADRD diagnosed with dysphagia, focusing on their characteristics, management strategies, and clinical progress.* -
  • Results showed that despite high risks, 76% of patients who received reassessment showed improvement in dysphagia, underscoring the need for regular evaluations and further research on respiratory complications linked to dysphagia management.*
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Purpose: To test the effectiveness and feasibility of a remotely delivered intervention to increase physical activity (walking) in middle-aged and older adults.

Design: This study used a personalized (N-of-1) trial design.

Setting: This study took place at a major healthcare system from November 2021 to February 2022.

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Association between Heat Vulnerability Index and Stroke Severity.

Int J Environ Res Public Health

August 2024

Northwell Health, New Hyde Park, NY 11040, USA.

Background: Socioeconomically disadvantaged neighborhoods are particularly vulnerable to heat-related illnesses. We aim to investigate the association between the heat vulnerability index (HVI), an established neighborhood-level metric of heat-related mortality risk, and acute ischemic stroke (AIS) severity.

Methods: We conducted a retrospective analysis of consecutive AIS admissions to a comprehensive stroke center between 2012 and 2021.

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Article Synopsis
  • - The study focused on integrating a new role, Palliative Care Educators (PCEs), into hospital settings to improve advance care planning (ACP) and goals-of-care (GOC) conversations for seriously ill and older patients.
  • - Interviews with 24 clinical staff revealed four main themes: PCEs laid a foundation for ongoing palliative care, creative revisions were necessary for their implementation, strong communication ensured continuity of care, and building trust led to greater role acceptance.
  • - Despite some challenges in creating this new role, it was viewed as beneficial in reducing staff workloads and enhancing patient engagement in important care discussions.
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Matters We Metric Vs. Metrics that Matter.

Geriatr Orthop Surg Rehabil

August 2024

International Geriatric Fracture Society Research Fellowship, Apopka, FL, USA.

Introduction: Geriatric fracture is a pressing global health issue, marked by elevated mortality and morbidity rates and escalating health care costs. The evolving health care system from fee-for-service to quality-based reimbursement has led to externally driven reward and reimbursement systems that may not account for the complexity of caring for older adults with fracture.

Significance: The aim of this review is to highlight the need for a shift towards meaningful metrics that impact geriatric fracture care and to issue a call to action for all medical societies to advocate for national reimbursement and ranking systems that focus on metrics that truly matter.

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Qualitative interviews for hospitalists addressing lung cancer screening.

Curr Probl Diagn Radiol

August 2024

Northwell, New Hyde Park, NY, USA; Institute of Health System Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA. Electronic address:

Novel strategies are needed to improve low rates of lung cancer screening (LCS) in the US. Seeking to determine hospitalists' perspectives on leveraging hospitalizations to identify patients eligible for LCS, we performed qualitative interviews with eight hospitalists from two hospitals within a large integrated healthcare system. The interviews used semi-structured questions to assess (1) knowledge and practice of general screening and LCS guidelines from the United States Preventive Services Task Force (USPSTF), (2) identification of smoking history, and (3) hospitalists' views on how data obtained during hospitalization may be utilized to improve general screening and LCS post hospitalization.

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Article Synopsis
  • Adverse social determinants of health significantly increase the risk of chronic health conditions, yet there's a lack of research on whether communities have adequate services to address these needs.
  • A geospatial analysis was conducted to assess the coverage of social care providers in relation to the locations of Kaiser Permanente Northwest members suffering from various health-related social needs (HRSNs), such as food insecurity and transportation issues.
  • The results showed that 97-98% of members with HRSNs lived within a 30-minute travel distance to a provider, indicating effective service availability, although some rural patients faced challenges in reaching care.
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Diagnostic Accuracy of Cone-Beam CT for Acute Intracranial Hemorrhage: A Systematic Review and Meta-Analysis.

J Am Coll Radiol

December 2024

Northwell, New Hyde Park, New York; Institute of Health System Science, The Feinstein Institutes for Medical Research, Manhasset, New York; Department of Radiology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York; Vice Chair of Research, Department of Radiology and Co-Director of PRIME (Policy Research and Imaging Effectiveness) Center, Neiman Health Policy Institute. Electronic address:

Article Synopsis
  • The study aimed to evaluate how accurate cone-beam CT (CBCT) is in diagnosing different types of intracranial hemorrhage (ICH), focusing on intraparenchymal, subarachnoid, and intraventricular hemorrhages.
  • A meta-analysis included seven studies with 466 patients, using multidetector CT as the reference standard; findings showed high sensitivity (0.88) and specificity (0.99) for identifying ICH.
  • The results indicated that while CBCT has moderate diagnostic odds ratios, it demonstrates high specificity, particularly for intraparenchymal hemorrhage with a sensitivity of 0.98.
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Perioperative Management of Patients Taking Direct Oral Anticoagulants: A Review.

JAMA

September 2024

Department of Medicine, Anticoagulation and Clinical Thrombosis Service, Northwell Health at Lenox Hill Hospital, New York, New York.

Importance: Direct oral anticoagulants (DOACs), comprising apixaban, rivaroxaban, edoxaban, and dabigatran, are commonly used medications to treat patients with atrial fibrillation and venous thromboembolism. Decisions about how to manage DOACs in patients undergoing a surgical or nonsurgical procedure are important to decrease the risks of bleeding and thromboembolism.

Observations: For elective surgical or nonsurgical procedures, a standardized approach to perioperative DOAC management involves classifying the risk of procedure-related bleeding as minimal (eg, minor dental or skin procedures), low to moderate (eg, cholecystectomy, inguinal hernia repair), or high risk (eg, major cancer or joint replacement procedures).

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