4 results match your criteria: "Institute of Geriatrics and Beijing Hospital[Affiliation]"
MicroRNA-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression.
J Cell Mol Med
August 2016
Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Recently, it is implicated that aberrant expression of microRNAs (miRs) is associated with insulin resistance. However, the role of miR-17 family in hepatic insulin resistance and its underlying mechanisms remain unknown. In this study, we provided mechanistic insight into the effects of miR-20a-5p, a member of miR-17 family, on the regulation of AKT/GSK pathway and glycogenesis in hepatocytes.
View Article and Find Full Text PDFHigh glucose reduces hepatic glycogenesis by suppression of microRNA‑152.
Mol Med Rep
October 2014
Key Laboratory of Geriatrics, Beijing Institute of Geriatrics and Beijing Hospital, Ministry of Health, Beijing 100730, P.R. China.
MicroRNAs (miRNAs) are a class of non‑coding 18‑25-nucleotide endogenous RNA molecules. miRNAs act as specific gene silencers to regulate target gene expression at the posttranscriptional level, by base pairing to the 3'‑untranslated region of the target mRNA. miR‑152 is an miRNA that was originally identified in cancer cells, and was shown to be able to modulate the expression of specific oncogenes and tumor suppressor genes, leading to enhanced carcinoma growth.
View Article and Find Full Text PDFAssociation between infectious diseases and type 1 diabetes: a case-crossover study.
Pediatr Diabetes
June 2006
Institute of Geriatrics and Beijing Hospital, Ministry of Health, Beijing, China.
Background: To investigate the role of infectious diseases in the development of type 1 diabetes, this study estimated the relative risks of type 1 diabetes immediately after infectious diseases.
Research Design And Methods: A case-crossover design was employed. Information on infectious diseases during 407 d before the onset of type 1 diabetes was collected from medical records and parents' interviews for 260 patients in Chinese type 1 diabetes registry.
Apparent protective effect of high density lipoprotein against coronary heart disease in the elderly.
Chin Med J (Engl)
April 2004
Biochemistry Laboratory, Beijing Institute of Geriatrics and Beijing Hospital, Ministry of Health, Beijing 100730, China.
Background: This study was designed to evaluate the relationship between high-density lipoprotein cholesterol (HDL-C) level and acute myocardial infarction (AMI) and coronary heart disease (CHD) death and to explore the protective effect of HDL against CHD in the elderly Chinese.
Methods: Started from 1986, 1211 retirees (92% males) were enrolled consecutively and studied prospectively. The average starting age was 70 +/- 9 years, and that at the end of the study was 80 +/- 9 years.