4 results match your criteria: "Institute of Genetics and Biophysics "A. Buzzati Traverso" (IGB-ABT)[Affiliation]"
, but Not Rutin, Inhibits Survival, Migration, Invasion, and Vasculogenic Mimicry of Glioblastoma Cells.
Int J Mol Sci
November 2024
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.
Glioblastoma (GBM) is the most aggressive type of brain tumor, characterized by poor outcome and limited therapeutic options. During tumor progression, GBM may undergo the process of vasculogenic mimicry (VM), consisting of the formation of vascular-like structures which further promote tumor aggressiveness and malignancy. The resulting resistance to anti-angiogenetic therapies urges the identification of new compounds targeting VM.
View Article and Find Full Text PDFαV-Integrin-Dependent Inhibition of Glioblastoma Cell Migration, Invasion and Vasculogenic Mimicry by the uPAcyclin Decapeptide.
Cancers (Basel)
September 2023
Institute of Genetics and Biophysics "A. Buzzati Traverso" (IGB-ABT), National Research Council of Italy, 80131 Naples, Italy.
Article Synopsis
- Glioblastoma (GBM) is one of the most aggressive human cancers, and there is a critical need for new treatment methods.
- Research on the cyclic decapeptide uPAcyclin shows it specifically binds to GBM cells and hinders their movement and ability to invade surrounding tissues without affecting their growth.
- uPAcyclin significantly reduces the formation of vascular-like structures in GBM cells, indicating its potential as a targeted therapy to prevent new blood vessel formation in treating GBM.
Histone Deacetylase Inhibitors Impair Vasculogenic Mimicry from Glioblastoma Cells.
Cancers (Basel)
May 2019
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.
Article Synopsis
- Glioblastoma (GBM) is a highly aggressive brain cancer that has poor treatment outcomes despite surgery, radiation, and chemotherapy.
- Antiangiogenic therapies, which target abnormal blood vessel growth in GBM, are often evaded due to the tumor's ability to undergo vasculogenic mimicry, a process where GBM forms its own blood supply.
- Research showed that histone deacetylase inhibitors (HDACis) like vorinostat and MC1568 effectively reduce tube formation and cell invasion in GBM, suggesting they could be valuable in targeting this alternate vascularization mechanism.
UMODL1/Olfactorin is an extracellular membrane-bound molecule with a restricted spatial expression in olfactory and vomeronasal neurons.
Eur J Neurosci
June 2005
Institute of Genetics and Biophysics-A. Buzzati Traverso, IGB-ABT, via P. Castellino 111, CNR, 80131 Naples, Italy.
The olfactory system provides a unique model for developmental neurobiology. Precise targeting of axonal projections from sensory neurons located in the olfactory epithelium to specific neurons in the olfactory bulb establishes a highly refined spatial sensory map. Distinctively, this process is not restricted to embryonic stages, but continues during the entire life of mammals.
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