Calcium Phosphate Nanoparticles Functionalized with a Cardio-Specific Peptide.

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, highliting the urgent need for new therapeutic strategies. Peptide-based therapies have demonstrated significant potential for treating CVDs; however, their clinical application is hindered by their limited stability in physiological fluids. To overcome this challenge, an effective drug delivery system is essential to protect and efficiently transport peptides to their intended targets.

Endoplasmic reticulum stress at the crossroads of progeria and atherosclerosis.

Hutchinson–Gilford progeria syndrome (HGPS) is a rare pathology caused by a specific mutation (.1824C>T; .G608G) in the gene (Eriksson , 2003).