Properties of liquid-crystal wave-guiding structures.

The paper presents the results of an experimental and numerical study of some properties of multimode liquid crystal waveguide structures. The nematic 4-cyano-4'-pentylbiphenyl (5CB) was used as a liquid crystal. A description of the experiments performed and some of the techniques used are given.

Annihilation of exceptional points from different Dirac valleys in a 2D photonic system.

Topological physics relies on Hamiltonian's eigenstate singularities carrying topological charges, such as Dirac points, and - in non-Hermitian systems - exceptional points (EPs), lines or surfaces. So far, the reported non-Hermitian topological transitions were related to the creation of a pair of EPs connected by a Fermi arc out of a single Dirac point by increasing non-Hermiticity. Such EPs can annihilate by reducing non-Hermiticity.

Tuning of Magnetic Hyperthermia Response in the Systems Containing Magnetosomes.

A number of materials are studied in the field of magnetic hyperthermia. In general, the most promising ones appear to be iron oxide particle nanosystems. This is also indicated in some clinical trial studies where iron-based oxides were used.

Brownian Motion Influence on AFM Exosomes' Size Measurements.

Extracellular vesicles are evaluated by nanoparticle tracking analysis (NTA), providing information on their hydrodynamic diameters, and by atomic force microscopy (AFM) to calculate their geometric diameters. The aim of this study is to explore the influence of Brownian movements in a sample drop and preparation time on imaging-based measurements and to determine the relationship between the geometric and hydrodynamic sizes of the extracellular vesicles measured by the AFM and the NTA, respectively. Exosomes derived from the human prostate cancer cell line PC3 were evaluated by NTA and AFM, and those results were compared with Monte Carlo simulations.

3D Impedance Modeling of Metal Anodes in Solid-State Batteries-Incompatibility of Pore Formation and Constriction Effect in Physical-Based 1D Circuit Models.

A non-ideal contact at the electrode/solid electrolyte interface of a solid-state battery arising due to pores (voids) or inclusions results in a geometric constriction effect that severely deteriorates the electric transport properties of the battery cell. The lack of understanding of this phenomenon hinders the optimization process of novel components, such as reversible and high-rate metal anodes. Deeper insight into the constriction phenomenon is necessary to correctly monitor interface degradation and to accelerate the successful use of metal anodes in solid-state batteries.

Anti-trypanosomatid structure-based drug design - lessons learned from targeting the folate pathway.

Introduction: Trypanosomatidic parasitic infections in humans and animals caused by , and species pose a significant health and economic burden in developing countries. There are few effective and accessible treatments for these diseases, and the existing therapies suffer from problems, such as parasite resistance and side effects. Structure-based drug design (SBDD) is one of the strategies that has been applied to discover new compounds targeting trypanosomatid-borne diseases.

Biosignature stability in space enables their use for life detection on Mars.

Two rover missions to Mars aim to detect biomolecules as a sign of extinct or extant life with, among other instruments, Raman spectrometers. However, there are many unknowns about the stability of Raman-detectable biomolecules in the martian environment, clouding the interpretation of the results. To quantify Raman-detectable biomolecule stability, we exposed seven biomolecules for 469 days to a simulated martian environment outside the International Space Station.

Dual role of oxygen-related defects in the luminescence kinetics of AlN:Mn.

This study presents the impact of temperature and pressure on AlN:Mn luminescence kinetics. Unusual behavior of Mn optical properties during UV excitation is observed, where a strong afterglow luminescence of Mn occurs even at low temperatures. When the temperature increases, the contribution of the afterglow luminescence is further enhanced, causing a significant increase in the luminescence intensity.

Preparation of RNAs with non-canonical 5' ends using novel di- and trinucleotide reagents for co-transcriptional capping.

Many eukaryotic and some bacterial RNAs are modified at the 5' end by the addition of cap structures. In addition to the classic 7-methylguanosine 5' cap in eukaryotic mRNA, several non-canonical caps have recently been identified, including NAD-linked, FAD-linked, and UDP-glucose-linked RNAs. However, studies of the biochemical properties of these caps are impaired by the limited access to transcribed RNA probes of high quality, as the typical capping efficiencies with NAD or FAD dinucleotides achieved in the presence of T7 polymerase rarely exceed 50%, and pyrimidine derivatives are not incorporated because of promoter sequence limitations.

The intriguing dose-dependent effect of selected amphiphilic compounds on insulin amyloid aggregation: Focus on a cholesterol-based detergent, Chobimalt.

The amyloidogenic self-assembly of many peptides and proteins largely depends on external conditions. Among amyloid-prone proteins, insulin attracts attention because of its physiological and therapeutic importance. In the present work, the amyloid aggregation of insulin is studied in the presence of cholesterol-based detergent, Chobimalt.

Search for Higgs Boson Pair Production in the Four b Quark Final State in Proton-Proton Collisions at sqrt[s]=13 TeV.

A search for pairs of Higgs bosons produced via gluon and vector boson fusion is presented, focusing on the four b quark final state. The data sample consists of proton-proton collisions at a center-of-mass energy of 13 TeV, collected with the CMS detector at the LHC, and corresponds to an integrated luminosity of 138  fb^{-1}. No deviation from the background-only hypothesis is observed.

Multispectral time-resolved energy-momentum microscopy using high-harmonic extreme ultraviolet radiation.

A 790-nm-driven high-harmonic generation source with a repetition rate of 6 kHz is combined with a toroidal-grating monochromator and a high-detection-efficiency photoelectron time-of-flight momentum microscope to enable time- and momentum-resolved photoemission spectroscopy over a spectral range of 23.6-45.5 eV with sub-100 fs time resolution.

2'-O-Methylation of the second transcribed nucleotide within the mRNA 5' cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion.

In mammals, m7G-adjacent nucleotides undergo extensive modifications. Ribose of the first or first and second transcribed nucleotides can be subjected to 2'-O-methylation to form cap1 or cap2, respectively. When the first transcribed nucleotide is 2'-O-methylated adenosine, it can be additionally modified to N6,2'-O-dimethyladenosine (m6Am).

Observation of WWW Production in pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector.

This Letter reports the observation of WWW production and a measurement of its cross section using 139  fb^{-1} of proton-proton collision data recorded at a center-of-mass energy of 13 TeV by the ATLAS detector at the Large Hadron Collider. Events with two same-sign leptons (electrons or muons) and at least two jets, as well as events with three charged leptons, are selected. A multivariate technique is then used to discriminate between signal and background events.

A Polyclonal SELEX Aptamer Library Allows Differentiation of , and Cells from Human Dermal Fibroblasts.

Easy and reliable identification of pathogenic species such as yeasts, emerging as problematic microbes originating from the genus , is a task in the management and treatment of infections, especially in hospitals and other healthcare environments. Aptamers are seizing an already indispensable role in different sensing applications as binding entities with almost arbitrarily tunable specificities and optimizable affinities. Here, we describe a polyclonal SELEX library that not only can specifically recognize and fluorescently label cells, but is also capable to differentiate , and cells in flow-cytometry, fluorometric microtiter plate assays and fluorescence microscopy from human cells, exemplified here by human dermal fibroblasts.

New Derivatives of 5-((1-Methyl-Pyrrol-2-yl) Methyl)-4-(Naphthalen-1-yl)-1,2,4-Triazoline-3-Thione and Its Coordination Compounds with Anticancer Activity.

A new ligand 5-((1-methyl-pyrrol-2-yl) methyl)-4-(naphthalen-1-yl)-1,2,4-triazoline-3-thione (C15) and its metal complexes with formulae: Mn(C15)ClMeOH (), Fe(C15)ClMeOH (), Ni(C15)ClMeOH (), Cu(C15)Cl () and Zn(C15)Cl () have been synthesized. The C15 ligand and complexes were characterized by NMR, elemental analysis, FT-IR, EPR, magnetic and TGA studies. The anticancer activities of the organic ligand (C15) and complexes (-) were evaluated against human colon adenocarcinoma (HT29) and human lung (A549) cancer cell lines.

The Affect Misattribution in the Interpretation of Ambiguous Stimuli in Terms of Warmth vs. Competence: Behavioral Phenomenon and Its Neural Correlates.

Warmth and competence are fundamental dimensions of social cognition. This also applies to the interpretation of ambiguous symbolic stimuli in terms of their relation to warmth or competence. The affective state of an individual may affect the way people interpret the neutral stimuli in the environment.

SPECTROMETRY OF HIGH-ENERGY PHOTONS ON HIGH MOUNTAIN OBSERVATORY LOMNICKÝ ŠTÍT DURING THUNDERSTORMS.

Lomnický štít, Slovakia, 2634 m above sea level, is known to be a place of extreme electric fields measured during thunderstorms and is thus a suitable place for thunderstorm-related ionising radiation research. We present one of the strongest Thunderstorm ground enhancements (TGE) ever detected, which occurred on 12 September 2021. The TGE was detected with the SEVAN detector and also with the new Georadis RT-56 large volume gamma spectrometer.

Ground state and thermodynamic properties of the coupled double-Ising model: application to rare-earth tetraborides.

A combination of the standard Metropolis algorithm and the parallel tempering method is used to study ground-state and thermodynamic properties of the coupled double Ising (CDI) model on the Shastry-Sutherland lattice (SSL). This model is derived from the complex spin-electron model, in which electrons described by the Hubbard model and spins described by the Ising model interact via the anisotropic spin-dependent interaction of the Ising type, under the following three conditions: (a) the Hubbard interaction between electrons in the conduction band is sufficiently large; (b) the number of conduction electrons is equal to the number of the lattice points; (c) there is the easy axis spin anisotropy in the system. The model is solved numerically for the selected combinations of spins from the electron (s=1/2) and spin (S=1,3/2,2) Ising branch which represent very realistically the situation in TmB, ErBand HoBcompounds, where in addition all three conditions are simultaneously satisfied.

Temperature induced modulation of resonant Raman scattering in bilayer 2H-MoS.

The temperature evolution of the resonant Raman scattering from high-quality bilayer 2H-MoS[Formula: see text] encapsulated in hexagonal BN flakes is presented. The observed resonant Raman scattering spectrum as initiated by the laser energy of 1.96 eV, close to the A excitonic resonance, shows rich and distinct vibrational features that are otherwise not observed in non-resonant scattering.

Estimating near-wall diffusion coefficients of arbitrarily shaped rigid macromolecules.

We developed a computationally efficient approach to approximate near-wall diffusion coefficients of arbitrarily shaped rigid macromolecules. The proposed method relies on extremum principles for Stokes flows produced by the motion of rigid bodies. In the presence of the wall, the rate of energy dissipation is decreased relative to the unbounded fluid.

Search for Flavor-Changing Neutral Current Interactions of the Top Quark and Higgs Boson in Final States with Two Photons in Proton-Proton Collisions at sqrt[s]=13 TeV.

Proton-proton interactions resulting in final states with two photons are studied in a search for the signature of flavor-changing neutral current interactions of top quarks (t) and Higgs bosons (H). The analysis is based on data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 137  fb^{-1}. No significant excess above the background prediction is observed.