Assessing the Fiscal Burden of Overweight and Obesity in Japan through Application of a Public Economic Framework.

Obesity continues to represent a significant public health concern, with a broad impact from both a health and economic perspective. This analysis assesses the fiscal consequences of overweight and obesity (OAO) in Japan by capturing obesity-attributable lost tax revenue and increased government transfers using a government perspective. The fiscal burden of OAO was estimated using an age-specific prevalence model, which tracked the Japanese population across different body mass index (BMI) categories.

Crossing the wicked frontier. Why sustainability science needs integrative research.

Integrative research approaches have lost prominence in the scientific literature, and related concepts of 'wicked problems' and 'post-normal science' complement but do not adequately replace them. From a detailed examination of the foundational literature, three key principles are shown to be central to integrative research: (i) the knowledge cycle; (ii) representativeness and participation; and (iii) knowledge exchange mechanisms at the science-policy interface. As an example of the importance of the integrative research framework in the context of policy-relevant science, it is argued that the shortcomings of current climate change mitigation efforts arise from inappropriately 'closing down' the science-policy interface and focusing on a few narrow options acceptable to powerful stakeholders.

Optimal vaccine allocation strategy: Theory and application to the early stage of COVID-19 in Japan.

In this paper, we construct an age-structured epidemic model to analyze the optimal vaccine allocation strategy in an epidemic. We focus on two topics: the first one is the optimal vaccination interval between the first and second doses, and the second one is the optimal vaccine allocation ratio between young and elderly people. On the first topic, we show that the optimal interval tends to become longer as the relative efficacy of the first dose to the second dose (RE) increases.

Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants.

The heterogeneity of systemic lupus erythematosus (SLE) can be explained by epigenetic alterations that disrupt transcriptional programs mediating environmental and genetic risk. This study evaluated the epigenetic contribution to SLE heterogeneity considering molecular and serological subtypes, genetics and transcriptional status, followed by drug target discovery. We performed a stratified epigenome-wide association studies of whole blood DNA methylation from 213 SLE patients and 221 controls.

Investigating the causal effects of COVID-19 vaccination on the adoption of protective behaviors in Japan: Insights from a fuzzy regression discontinuity design.

Background: During the COVID-19 pandemic, concerns emerged that vaccinated individuals might engage less in infection-preventive behaviors, potentially contributing to virus transmission. This study evaluates the causal effects of COVID-19 vaccination on such behaviors within Japan, highlighting the significance of understanding behavioral dynamics in public health strategies.

Methods: Utilizing Japan's age-based vaccination priority for those born before April 1, 1957, this research employs a regression discontinuity design (RDD) to assess the vaccination's impact.

Japan's intensive health guidance program has limited effects on cardiovascular risk factors: a regression discontinuity analysis.

Objectives: It is uncertain whether the effects of health counselling programs differ depending on their intensity. This study compared the effectiveness of intensive health guidance (IHG) and less intensive motivation-enhancing guidance (MEG) on cardiovascular risk factors.

Study Design: A regression discontinuity design (RDD) was applied.

Heterogeneous risk attitudes and waves of infection.

Many countries have experienced multiple waves of infection during the COVID-19 pandemic. We propose a novel but parsimonious extension of the SIR model, a CSIR model, that can endogenously generate waves. In the model, cautious individuals take appropriate prevention measures against the virus and are not exposed to infection risk.

Is air pollution exposure linked to household income? Spatial analysis of Community Multiscale Air Quality Model results for Madrid.

This study explores the potential correlation between income and exposure to air pollution for the city of Madrid, Spain and its neighboring municipalities. Madrid is a well-known European air pollution hotspot with a high mortality burden attributable to nitrogen dioxide (NO) and fine particulate matter (PM). Statistical analyses were carried out using electoral district level data on gross household income (GHI), and NO and PM concentrations in air obtained from a mesoscale air quality model for the study area.

Empirical evidence of predictive adaptive response in humans: systematic review and meta-analysis of migrant populations.

Meta-analysis is used to test a variant of a Developmental Origins of Adult Health and Disease (DOHaD)'s conjecture known as predictive adaptive response (PAR). According to it, individuals who are exposed to mismatches between adverse or constrained conditions, on the one hand, and postnatal obesogenic environments, on the other, are at higher risk of developing adult chronic conditions, including obesity, type 2 diabetes (T2D), hypertension and cardiovascular disease. We argue that migrant populations from low and middle to high-income countries offer a unique opportunity to test the conjecture.

Disruption of international trade and its propagation through firm-level domestic supply chains: A case of Japan.

This study simulates how the disruption of imports from various regions affects the total production of the importer economy. We particularly incorporate the propagation of the economic effect through domestic supply chains using data on more than one million firms and four million supply chain ties in Japan. Our findings are summarized as follows.

The impact of a mobile app-based corporate sleep health improvement program on productivity: Validation through a randomized controlled trial.

Based on a randomized controlled trial applied to employees of a manufacturing company, this study examines the extent to which a corporate sleep program improves workers' sleep health and productivity. In the three-month sleep improvement program, applicants were randomly divided into a treatment group and a control group, and the treatment group was provided with a noncontact sensing device to visualize their sleep. A smartphone app linked to the device notified them of their sleep data every morning and presented them with advice on behavioral changes to improve their sleep on a weekly basis.

Influence of Place of Birth on Adult Mortality: The Case of Spain.

We use a unique data set from Spain and we estimate life expectancy at age 50 for males and females by place of residence and place of birth. We show that, consistent with expectations regarding the influence of early conditions on adult health and mortality, the effects of place of birth on adult mortality are very strong, irrespective of place of residence. Furthermore, we find that mortality levels observed in a place are strongly influenced by the composition of migrants by place of birth.

Impact of the COVID-19 pandemic on exercise habits and overweight status in Japan: A nation-wide panel survey.

A catastrophic disaster may cause distant health impacts like immobility and obesity. The aim of this research was to analyse the association of the COVID-19 pandemic and lifestyle factors -exercise habit and overweight status in the Japanese population. Nation-wide online questionnaires were conducted five times from October 2020 to October 2021.

Simulation of supply chain disruptions considering establishments and power outages.

In this paper, we simulate the economic loss resulting from supply chain disruptions triggered by the Great East Japan Earthquake (GEJE) in 2011, applying data from firm-level supply chains and establishment-level attributes to an agent-based model. To enhance the accuracy of the simulation, we extend data and models in previous studies in four ways. First, we identify the damage to production facilities in the disaster-hit regions more accurately by using establishment-level census and survey data and geographic information system (GIS) data on the damages caused by the GEJE and subsequent tsunami.

Compliance costs and productivity: an approach from working hours.

This study proposes a new approach of measuring compliance costs of rules and regulations by focusing on labor input, and estimates the compliance costs in Japan based on a survey of workers. According to the results, the working hours required to comply with rules and regulations account for more than 20% of total labor input. By industry, this cost is higher in the finance and insurance industry followed by the health and welfare industry, and by firm size, it is higher in large firms.

Effects of being eligible for specific health guidance on health outcomes: A regression discontinuity analysis using Japan's data on specific health checkups.

The significance of general health checkups and guidance is controversial. To examine the effectiveness of Japan's specific health checkup (SHC) and specific health guidance (SHG) programs, this study applied a regression discontinuity design (RDD) using the SHC results database collected by a private company. We applied a sharp RDD with a cutoff body mass index (BMI) of 25 kg/m for those with a waist circumference (WCF) of <85 cm in men and < 90 cm in women, with risks of hypertension, dyslipidemia or diabetes, and aged between 40 and 64 years.

Declared Intention to Vaccinate against COVID-19 and Actual Vaccination-The Role of Trust in Science, Conspiratorial Thinking and Religiosity.

Aims: The study aims to investigate how trust in science, conspiratorial thinking, and religiosity affected people's declared willingness to vaccinate against COVID-19 at the onset of the vaccination program in Poland, their actual vaccination, and the consistency between intention and vaccination.

Methods: In a longitudinal design, a representative sample of 918 members of the Polish general population was polled at the beginning of the vaccination program (February 2021) and polled again after 6 months of mass vaccination (August 2021). We measured the willingness to vaccinate, actual vaccination after 6 months, and individual variables-trust in science, conspiratorial thinking and religiosity.

Robustness and resilience of supply chains during the COVID-19 pandemic.

Using a unique firm-level data set from Asia, this study examines what determined the robustness and resilience of supply chain links, that is, the ability of maintaining links and recovering disrupted links by substitution, respectively, when firms faced economic shocks due to the spread of the coronavirus disease (COVID-19). We find that a supply chain link was likely to be robust if the link was between a foreign-owned firm and a firm located in the foreign-owned firm's home country, implying that homophily on a certain dimension generates strong ties and thus supply chain robustness. We also find that firms with geographic diversity of customers and suppliers tended to increase their transaction volume with one partner while decreasing the volume with others.

Two-dimensional constrained chaos and industrial revolution cycles.

Since the 1760s, at least three industrial revolutions have occurred. To explain this phenomenon, we introduce two-dimensional (2D) constrained chaos. Using a model of innovation dynamics, we show that an industrial-revolution-like technology burst, driven by investment/saving motives for R&D activities, recurs about every one hundred years if the monopolistic use of a new technology lasts about 8 y.

Has Covid-19 permanently changed online purchasing behavior?

Unlabelled: This study examines how the COVID-19 pandemic has affected online purchasing behavior using data from a major online shopping platform in Japan. We focus on the effect of two measures of the pandemic, i.e.

Temporal variation of the temperature-mortality association in Spain: a nationwide analysis.

Background: Although adaptation to continuously rising ambient temperatures is an emerging topic and has been widely studied at a global scale, detailed analysis of the joint indicators for long-term adaptation in Spain are scarce. This study aims to explore temporal variations of the minimum mortality temperature and mortality burden from heat and cold between 1979 and 2018.

Methods: We collected individual all-cause mortality and climate reanalysis data for 4 decades at a daily time step.

Tax havens and cross-border licensing with transfer pricing regulation.

Multinational enterprises (MNEs) have incentive to reduce tax payment through transfer pricing. The incentive is stronger when MNEs own intangibles, because it is easy to transfer them across countries. To mitigate such strategic tax planning, the OECD proposes the arm's length principle (ALP).

Mortality impact of the Covid-19 epidemic on immigrant populations in Spain.

Immigrant populations have been shown to display a disproportionately high mortality burden during the Covid-19 epidemic in some high-income countries. Individual civil registration data from Spain, one of the countries with the highest Covid-19 mortality in Europe, was used in order to characterize mortality during the Covid-19 epidemic for different immigrant groups. Individuals born in South America, Sub-Saharan Africa and Asia are shown to have suffered higher mortality impact than the native-born, particularly at working ages (40-59 years old), which could be due to higher proportions of immigrants from these regions among key workers.

Assessment of portfolio investment effectiveness during the covid-19 pandemic - multivariate fundamental approach.

Making long-term investment decisions is possible using the portfolio approach. In this respect, there are classical (e.g.

Ecological effectiveness of marine protected areas across the globe in the scientific literature.

A systematic literature review (SLR) of scientific articles on the effectiveness of marine protected areas (MPAs) to conserve biodiversity in the 2010-2019 decade using Scopus was done. Only studies that used Before-After-Control-Impact (BACI-type) research designs and at least one marine biodiversity indicator were included. The 23 studies included in the review were published in 19 journals and comprised 66 MPAs from 18 countries from the five continents.