5 results match your criteria: "Institute of ENT and Longgang ENT Hospital[Affiliation]"

Brusatol attenuated proliferation and invasion induced by KRAS in differentiated thyroid cancer through inhibiting Nrf2.

J Endocrinol Invest

May 2024

Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.

Background: Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) can be developed from differentiated thyroid cancer, and this dedifferentiated transformation leads to poor prognosis and high mortality. The role of Nrf2 in the dedifferentiation of differentiated thyroid cancer (DTC) induced by KRAS remains unclear.

Methods And Materials: In this study, two DTC cell lines, BCPAP and WRO, were used to evaluate the function of Nrf2 in the dedifferentiation caused by wild-type KRAS (KRAS-WT) and G12V point mutation KRAS (KRAS-G12V).

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Article Synopsis
  • Marine natural products like dysiarenone show potential as new anti-inflammatory drug candidates, targeting inflammation and oxidative stress.
  • The study involved LPS-stimulated RAW 264.7 cells to evaluate dysiarenone’s effects on cell viability, inflammatory cytokine release, and reactive oxygen species levels.
  • Results indicate that dysiarenone effectively reduces inflammation and oxidative stress by modulating key signaling pathways, suggesting its promise for future therapeutic development.
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[The radiologic study of the nasolacrimal duct decompression surgery for treatment of chronic].

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi

February 2017

Department of Otolaryngology Head and Neck Surgery, Shenzhen Key Laboratory of ENT, Institute of ENT and Longgang ENT Hospital.

To explore the possibility of endoscopic nasolacrimal duct decompression surgery for the treatment of chronic dacryocystitis.①Twenty-two eyes with chronic dacryocystitis were treated with 30% iohexol injection for lacrimal sac lithography. Contrast agents were taken from the lacrimal canal reflux to stop the injection.

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