Characteristics and Antitumor Activity of Doxorubicin-Loaded Multifunctional Iron Oxide Nanoparticles in MEC1 and RM1 Cell Lines.

The rapid progress in nanotechnology has introduced multifunctional iron oxide nanoparticles as promising agents in cancer treatment. This research focused on the synthesis and assessment of citric-acid-coated, folic-acid-conjugated nanoparticles loaded with doxorubicin, evaluating their therapeutic potential in tumor models. An advanced automated continuous technology line (CTL) utilizing a controlled co-precipitation method was employed to produce highly dispersive, multifunctional nanofluids with a narrow size distribution.

PROSTATE CANCER DIAGNOSTICS MODELING USING THE INFRARED IMAGING METHOD.

Background: Imaging plays an important role in the identification of prostate cancer (PCa). However, a shortcoming of the current imaging techniques is their inability to detect PCa at an early stage of development when tumor volume is small. This led us to explore new and improved imaging methods.

A consistent decision support system for interpreting of magnetocardiographic data as a tool to improve the acceptance of magnetocardiography in clinical practice.

Background: Magnetocardiography undoubtedly has exceptionally high sensitivity to electrophysiological changes in the myocardium. This is an absolutely non-invasivemethod with no contraindications. However, several barriers exist to the widespread adoption of this technique into clinical routine.

Efficacy and safety of Abdala COVID-19 subunit vaccine in children and adolescents: An open-label, single-arm, phase 2 trial (MEÑIQUE).

Objectives We evaluated the safety, immunogenicity and efficacy of Abdala, a protein subunit vaccine for 2019 coronavirus disease (COVID-19), in children and adolescents. Methods A phase 2, open-label, single-arm clinical trial was carried out. Subjects aged 3 to 18 years were eligible.

How international organizations can support the development of cardio-oncology in the Latin American and the Caribbean region.

Health problems in the Latin American and the Caribbean (LAC) region are highly concentrated on non-communicable diseases, being cardiovascular diseases (CVDs) and cancer the leading causes of death. Different countries of the region are at different stages of development in addressing CVDs and cancer. Opportunities for training and continuing education in cardio-oncology, as well as active cardio-oncology groups, are primarily limited to large academic institutions in major metropolitan areas.

Innovative Hybrid Cloud Solutions for Physical Medicine and Telerehabilitation Research.

Purpose: The primary objective of this study was to develop and implement a Hybrid Cloud Environment for Telerehabilitation (HCET) to enhance patient care and research in the Physical Medicine and Rehabilitation (PM&R) domain. This environment aims to integrate advanced information and communication technologies to support both traditional in-person therapy and digital health solutions.

Background: Telerehabilitation is emerging as a core component of modern healthcare, especially within the PM&R field.

The Geometry of Normal Tissue and Cancer Gene Expression Manifolds.

A recent paper shows that in gene expression space the manifold spanned by normal tissues and the manifold spanned by the corresponding tumors are disjoint. The statement is based on a two-dimensional projection of gene expression data. In the present paper, we show that, for the multi-dimensional vectors defining the centers of cloud samples: 1.

Combination therapy of Epidermal Growth Factor and Growth Hormone-Releasing Hexapeptide in acute ischemic stroke: a phase I/II non-blinded, randomized clinical trial.

Objective: This study tested the hypothesis that a neuroprotective combined therapy based on epidermal growth factor (EGF) and growth hormone-releasing hexapeptide (GHRP6) could be safe for acute ischemic stroke patients, admitting up to 30% of serious adverse events (SAE) with proven causality.

Methods: A multi-centric, randomized, open-label, controlled, phase I-II clinical trial with parallel groups was conducted (July 2017 to January 2018). Patients aged 18-80 years with a computed tomography-confirmed ischemic stroke and less than 12 h from the onset of symptoms were randomly assigned to the study groups I (75 μg rEGF + 3.

Insight into the Digital Health System of Ukraine (eHealth): Trends, Definitions, Standards, and Legislative Revisions.

Purpose: This article aims to provide an in-depth examination of the digital health system of Ukraine, focusing on the emerging trends, precise definitions, established standards, and recent legislative revisions that shape the practice and implementation of eHealth solutions within the country.

Background: The digital health landscape in Ukraine has witnessed significant transformations, especially in the wake of the COVID-19 pandemic and subsequent military conflicts. These events have catalyzed the expansion of telemedicine services, leading to innovative approaches in healthcare delivery.

Development of in situ high resolution NMR: Proof-of-principle for a new (spinning) cylindrical mini-pellet approach applied to a Lithium ion battery.

Solid-state nuclear magnetic resonance (ssNMR) spectroscopy is a powerful technique for characterizing the local structure and dynamics of battery and other materials. It has been widely used to investigate bulk electrode compounds, electrolytes, and interfaces. Beside common ex situ investigations, in situ and operando techniques have gained considerable importance for understanding the reaction mechanisms and cell degradation of electrochemical cells.

NeuroEPO plus (NeuralCIM) in mild-to-moderate Alzheimer's clinical syndrome: the ATHENEA randomized clinical trial.

Background: NeuroEPO plus is a recombinant human erythropoietin without erythropoietic activity and shorter plasma half-life due to its low sialic acid content. NeuroEPO plus prevents oxidative damage, neuroinflammation, apoptosis and cognitive deficit in an Alzheimer's disease (AD) models. The aim of this study was to assess efficacy and safety of neuroEPO plus.

Letter to the Editor - Update from Ukraine: Development of the Cloud-based Platform for Patient-centered Telerehabilitation of Oncology Patients with Mathematical-related Modeling.

This Letter to the Editor provides an update on the research from the Glushkov Institute of Cybernetics of the National Academy of Sciences of Ukraine. The Institute's research team in collaboration with Ternopil National Medical University began a new project called "Development of the cloud-based platform for patient-centered telerehabilitation of oncology patients with mathematical-related modeling." The project is dedicated to the development of a hybrid cloud-based platform, and the creation on its basis of information technology for the telemedicine rehabilitation of cancer patients, and adapted for patients with combat stress disorder.

Letter to the Editor - Update from Ukraine: Rehabilitation and Research.

This Letter to the Editor provides an update on the research from the Glushkov Institute of Cybernetics of the National Academy of Sciences of Ukraine. The Institute's clinical research team is currently rehabilitating the military personnel of the Defense Forces of Ukraine with combat stress reaction and post-traumatic stress disorder using hybrid e-rehabilitation methods and techniques. Current research in the field of digital health and IoMT in Ukraine is creating innovative information technology for computerized electrocardiography.

Nematic-isotropic phase transitions in thin slabs of liquid crystals with topological defect arrays.

We study the nematic-to-isotropic phase transitions in thin slabs of nematic liquid crystals with photopatterned director fields of topological defect arrays at constant heating rates and show that the transition kinetics is significantly impacted by both the heating rate and the topological strengths of these defects. Specifically, with ±1/2 defect arrays, the isotropic domains emerge from the defect cores when the heating rate is high, while from random places when the heating rate is low. With ±1 defect arrays, the isotropic domains always emerge from the defect cores regardless of the heating rate.

HEART RATE VARIABILITY AS AN OBJECTIVE CRITERION FOR THE PSYCHO-EMOTIONAL STATE OF COMBATANTS.

Objective: The aim: To evaluate the functioning of the autonomic nervous system in combatants, the relationship between the heat rate variability (HRV) and ques¬tionnaire indicators, to improve the diagnosis of post-traumatic stress disorder (PTSD) and to evaluate the effectiveness of Transcendental Meditation (TM).

Patients And Methods: Materials and methods: 57 combatants and 30 civilians, with registering ECG and HRV-analysis, self-questionnaire testing.

Results: Results: The combatants' group showed an increase in heart rate, in the degree of centralisation of heart rate control and the R.

Assessment of the activities physiological cost of the defense forces officers in Ukraine using miniature ECG device.

Introduction: In the principles of the organization of armed struggle of the defense forces of most developed countries of the world, considerable attention is paid to the evaluation of combat readiness of the military personnel. This procedure is conditioned by such interconnected goals of the armed struggle as the maximum realization of the combat potential and the minimization of personnel losses. The purpose of the work is to determine the physiological cost of the activities of the soldiers of the Defense Forces of Ukraine with the help of miniature electrocardiographic hardware and software complexes.

High and fast: NMR protein-proton side-chain assignments at 160 kHz and 1.2 GHz.

The NMR spectra of side-chain protons in proteins provide important information, not only about their structure and dynamics, but also about the mechanisms that regulate interactions between macromolecules. However, in the solid-state, these resonances are particularly difficult to resolve, even in relatively small proteins. We show that magic-angle-spinning (MAS) frequencies of 160 kHz, combined with a high magnetic field of 1200 MHz proton Larmor frequency, significantly improve their spectral resolution.

Immunogenicity and safety assessment of a SARS-CoV-2 recombinant spike RBD protein vaccine (Abdala) in paediatric ages 3-18 years old: a double-blinded, multicentre, randomised, phase 1/2 clinical trial (ISMAELILLO study).

Background: COVID-19 in paediatric ages could result in hospitalizations and death. In addition, excluding children from vaccination could turn them into reservoirs of the SARS-COV-2. Safe and effective COVID-19 vaccines are urgently needed for large-scale paediatric vaccination.

Synthesis, Characterization, and In Vitro Cytotoxicity Evaluation of Doxorubicin-Loaded Magnetite Nanoparticles on Triple-Negative Breast Cancer Cell Lines.

In this study, we investigated the cytotoxicity of doxorubicin (DOX)-loaded magnetic nanofluids on 4T1 mouse tumor epithelial cells and MDA-MB-468 human triple-negative breast cancer (TNBC) cells. Superparamagnetic iron oxide nanoparticles were synthesized using sonochemical coprecipitation by applying electrohydraulic discharge treatment (EHD) in an automated chemical reactor, modified with citric acid and loaded with DOX. The resulting magnetic nanofluids exhibited strong magnetic properties and maintained sedimentation stability in physiological pH conditions.

Dynamic models of epidemiology in discrete time taking into account processes with lag.

Models of epidemic dynamics in the form of systems of differential equations of the type SIR and its generalizations, for example SEIR and SIRS, have become widespread in epidemiology. Their coefficients are averages of some epidemic indicators, for example the time when a person is contagious. Statistical data about spreading of the epidemic are known in discrete periods of time, for example twenty-four hours.

Variants of the Stochastic Sir Models and Vaccination Strategies.

Several options of the stochastic SIR epidemics model with limited treatment are proposed. For these methods, the efficiency of different vaccination strategies is demonstrated, and a method for obtaining the optimal vaccination strategy minimizing the cost functional is proposed.

Hybrid e-rehabilitation services: SMART-system for remote support of rehabilitation activities and services.

One of the most effective solutions in medical rehabilitation assistance is remote patient / person-centered rehabilitation. Rehabilitation also needs effective methods for the "Physical therapist - Patient - Multidisciplinary team" system, including the statistical processing of large volumes of data. Therefore, along with the traditional means of rehabilitation, as part of the "Transdisciplinary intelligent information and analytical system for the rehabilitation processes support in a pandemic (TISP)" in this paper, we introduce and define: the basic concepts of the new hybrid e-rehabilitation notion and its fundamental foundations; the formalization concept of the new Smart-system for remote support of rehabilitation activities and services; and the methodological foundations for the use of services (UkrVectōrēs and vHealth) of the remote Patient / Person-centered Smart-system.

Hyperspectral imaging of lipids in biological tissues using near-infrared and shortwave infrared transmission mode: A pilot study.

Label-free hyperspectral imaging (HSI) of lipids was demonstrated in the near-infrared (NIR) and shortwave infrared (SWIR) regions (950-1800 nm) using porcine tissue. HSI was performed in the transmission light-pass configuration, using a NIR-SWIR camera coupled with a liquid crystal tunable filter. The transmittance spectra of the regions of interest (ROIs), which correspond to the lipid and muscle areas in the specimen, were utilized for the spectrum unmixing.