Common and stimulus-type-specific brain representations of negative affect.

The brain contains both generalized and stimulus-type-specific representations of aversive events, but models of how these are integrated and related to subjective experience are lacking. We combined functional magnetic resonance imaging with predictive modeling to identify representations of generalized (common) and stimulus-type-specific negative affect across mechanical pain, thermal pain, aversive sounds and aversive images of four intensity levels each. This allowed us to examine how generalized and stimulus-specific representations jointly contribute to aversive experience.

Individual variability in brain representations of pain.

Characterizing cerebral contributions to individual variability in pain processing is crucial for personalized pain medicine, but has yet to be done. In the present study, we address this problem by identifying brain regions with high versus low interindividual variability in their relationship with pain. We trained idiographic pain-predictive models with 13 single-trial functional MRI datasets (n = 404, discovery set) and quantified voxel-level importance for individualized pain prediction.

An Image Based Object Recognition System for Wound Detection and Classification of Diabetic Foot and Venous Leg Ulcers.

Venous leg ulcers and diabetic foot ulcers are the most common chronic wounds. Their prevalence has been increasing significantly over the last years, consuming scarce care resources. This study aimed to explore the performance of detection and classification algorithms for these types of wounds in images.

N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes.

Background: The transient receptor potential vanilloid 1 (TRPV1) participates in thermosensation and inflammatory pain, but its immunomodulatory mechanisms remain enigmatic. N-Oleoyl dopamine (OLDA), an endovanilloid and endocannabinoid, is a TRPV1 agonist that is produced in the central nervous system and the peripheral nervous system. We studied the anti-inflammatory effects and TRPV1-dependent mechanisms of OLDA in models of inflammation and sepsis.

Associations Between Age and Resting State Connectivity Are Partially Dependent Upon Cardiovascular Fitness.

Previous research suggests a marked impact of aging on structural and functional connectivity within the frontoparietal control network (FPCN) and default mode network (DMN). As aging is also associated with reductions in cardiovascular fitness, age-related network connectivity differences reported by past studies could be partially due to age-related declines in fitness. Here, we use data collected as part of a 16-week exercise intervention to explore relationships between fitness and functional connectivity.

Social cognition deficits in amyotrophic lateral sclerosis: A pilot cross-sectional population-based study.

Background And Purpose: Social cognition (SC) deficits are included in amyotrophic lateral sclerosis (ALS)-frontotemporal spectrum disorder revised diagnostic criteria. However, SC performance among ALS patients is heterogeneous due to the phenotypic variability of the disease and the wide range of neuropsychological tools employed. The aim of the present study was to assess facial emotion recognition and theory of mind in ALS patients compared to controls and to evaluate correlations with the other cognitive domains and degree of motor impairment.

Mechanisms of associative word learning: Benefits from the visual modality and synchrony of labeled objects.

Despite humans' ability to communicate about concepts relating to different senses, word learning research tends to largely focus on labeling visual objects. Although sensory modality is known to influence memory and learning, its specific role for word learning remains largely unclear. We investigated associative word learning in adults, that is the association of an object with its label, by means of event-related brain potentials (ERPs).

Challenges facing interdisciplinary researchers: Findings from a professional development workshop.

Interdisciplinary research is the synergistic combination of two or more disciplines to achieve one research objective. Current research highlights the importance of interdisciplinary research in science education, particularly between educational experts within a particular science discipline (discipline-based education researchers) and those who study human learning in a more general sense (learning scientists). However, this type of interdisciplinary research is not common and little empirical evidence exists that identifies barriers and possible solutions.

Grounding co-writing: An analysis of the theoretical basis of a new approach in mental health care.

This contribution aims to highlight the theoretical and epistemological premises of the co-writing experience, a practice where a clinician and a patient are mutually engaged in jointly or collaboratively writing a narrative related to the patient's experience. Unlike a typical set of therapeutic techniques, co-writing is based on sharing perspectives and meanings about the experience of crisis, recovery, and the therapeutic process. The paper identifies and briefly describes four non-clinical epistemological paradigms on which it is grounded: ethnography, values-based practice, narrative care, and phenomenology.

Executive Functions and Impulsivity as Transdiagnostic Correlates of Psychopathology in Childhood: A Behavioral Genetic Analysis.

Executive functions (EFs) and impulsivity are dimensions of self-regulation that are both related to psychopathology. However, self-report measures of impulsivity and laboratory EF tasks typically display small correlations, and existing research indicates that impulsivity and EFs may tap separate aspects of self-regulation that independently statistically predict psychopathology in adulthood. However, relationships between EFs, impulsivity, and psychopathology may be different in childhood compared to adulthood.

Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport.

The microtubule-associated protein tau plays a central role in tauopathies such as Alzheimer's disease (AD). The exact molecular mechanisms underlying tau toxicity are unclear, but aging is irrefutably the biggest risk factor. This raises the question of how cellular senescence affects the function of tau as a microtubule regulator.

Using fNIRS to Identify Transparency- and Reliability-Sensitive Markers of Trust Across Multiple Timescales in Collaborative Human-Human-Agent Triads.

Intelligent agents are rapidly evolving from assistants into teammates as they perform increasingly complex tasks. Successful human-agent teams leverage the computational power and sensory capabilities of automated agents while keeping the human operator's expectation consistent with the agent's ability. This helps prevent over-reliance on and under-utilization of the agent to optimize its effectiveness.

Pupil size variations reveal covert shifts of attention induced by numbers.

The pupil light response is more than a pure reflexive mechanism that reacts to the amount of light entering the eye. The pupil size may also react to the luminance of objects lying in the visual periphery, revealing the locus of covert attention. In the present study, we took advantage of this response to study the spatial coding of abstract concepts with no physical counterpart: numbers.

Cooperative Behavior Evokes Interbrain Synchrony in the Prefrontal and Temporoparietal Cortex: A Systematic Review and Meta-Analysis of fNIRS Hyperscanning Studies.

Single-brain neuroimaging studies have shown that human cooperation is associated with neural activity in frontal and temporoparietal regions. However, it remains unclear whether single-brain studies are informative about cooperation in real life, where people interact dynamically. Such dynamic interactions have become the focus of interbrain studies.

Intentional gestural communication amongst red-capped mangabeys (Cercocebus torquatus).

Apes, human's closest living relatives, are renowned for their intentional and highly flexible use of gestural communication. In stark contrast, evidence for flexible and intentional gestural communication in monkeys is scarce. Here, we investigated the intentionality and flexibility of spontaneous gesture use in red-capped mangabeys (Cercocebus torquatus).

Complexity and Feedback During Script Training in Aphasia: A Feasibility Study.

Objective: To explore the effect of complexity and feedback on script training outcomes in aphasia DESIGN: Randomized balanced single-blind 2 × 2 factorial design.

Setting: Freestanding urban rehabilitation hospital.

Participants: Adults with fluent and nonfluent aphasia (at least 6 months post onset).

Phenomenological assessment of psychedelics induced experiences: Translation and validation of the German Challenging Experience Questionnaire (CEQ) and Ego-Dissolution Inventory (EDI).

Several measures have been designed to assess subjective experiences induced by psychedelic substances or other mind-altering drugs as well as non-pharmacological methods. Recently, two self-report questionnaires have been introduced to measure acute adverse effects following psilocybin ingestion and the phenomenon of ego-dissolution associated with the use of psychedelics, respectively. The 26-item Challenging Experience Questionnaire assesses multiple facets of psilocybin induced experiences on seven subscales, whereas the 8-item Ego-Dissolution Inventory consists of a unidimensional scale.

Strategy-dependent effects of working-memory limitations on human perceptual decision-making.

Deliberative decisions based on an accumulation of evidence over time depend on working memory, and working memory has limitations, but how these limitations affect deliberative decision-making is not understood. We used human psychophysics to assess the impact of working-memory limitations on the fidelity of a continuous decision variable. Participants decided the average location of multiple visual targets.

Cannabis Use and Resting State Functional Connectivity in the Aging Brain.

Several lines of evidence suggest that older adults (aged 65+) sharply increased their cannabis use over the last decade, highlighting a need to understand the effects of cannabis in this age group. Pre-clinical models suggest that cannabinoids affect the brain and cognition in an age-dependent fashion, having generally beneficial effects on older animals and deleterious effects on younger ones. However, there is little research on how cannabis affects the brains of older adults or how older adults differ from younger adults who use cannabis.

Monitoring and Quantification of the Dynamics of Stress Granule Components in Living Cells by Fluorescence Decay After Photoactivation.

Stress granules (SGs) are cytosolic, nonmembranous RNA-protein (RNP) complexes that form in the cytosol of many cells under various stress conditions and can integrate responses to various stressors. Although physiological SG formation appears to be an adaptive and survival-promoting mechanism, inappropriate formation or chronic persistence of SGs has been linked to aging and various neurodegenerative diseases. The quantitative monitoring of the dynamics of SG components in living nerve cells can therefore be an important tool for identifying conditions that disrupt SG function and lead to disease-related attacks in the cells.

Application of insects to wounds of self and others by chimpanzees in the wild.

Self-medication refers to the process by which a host suppresses or prevents the deleterious effects of parasitism and other causes of illness via behavioural means. It has been observed across multiple animal taxa (e.g.

Neuroanatomical Correlates of Perceived Stress Controllability in Adolescents and Emerging Adults.

Stressful life events predict changes in brain structure and increases in psychopathology, but not everyone is equally affected by life stress. The learned helplessness theory posits that perceiving life stressors as uncontrollable leads to depression. Evidence supports this theory for youth, but the impact of perceived control diverges based on stressor type: perceived lack of control over dependent (self-generated) stressors is associated with greater depression symptoms when controlling for the frequency of stress exposure, but perceived control over independent (non-self-generated) stressors is not.

Antilocality effect without head-final dependencies.

Antilocality effects provide strong evidence for expectation-based sentence parsing models. Previous discussion of the antilocality effect, however, largely focused on the argument-verb dependencies in verb-final constructions, for which a memory retrieval-based account has been argued to be equally adequate. To test whether the principles of expectation/memory-based accounts hold for a wider range of dependencies, we report on two self-paced reading experiments that compared two different determiners in German: the morphologically complex determiner 'the-jenig,' which obligatorily requires a relative clause, and the bare determiner 'the,' which does not trigger such expectations.