Histological and electrophysiological evidence on the safe operation of a sharp-tip multimodal optrode during infrared neuromodulation of the rat cortex.

Infrared neuromodulation is an emerging technology in neuroscience that exploits the inherent thermal sensitivity of neurons to excite or inhibit cellular activity. Since there is limited information on the physiological response of intracortical cell population in vivo including evidence on cell damage, we aimed to create and to validate the safe operation of a microscale sharp-tip implantable optrode that can be used to suppress the activity of neuronal population with low optical power continuous wave irradiation. Effective thermal cross-section and electric properties of the multimodal microdevice was characterized in bench-top tests.

From End to End: Gaining, Sorting, and Employing High-Density Neural Single Unit Recordings.

The meaning behind neural single unit activity has constantly been a challenge, so it will persist in the foreseeable future. As one of the most sourced strategies, detecting neural activity in high-resolution neural sensor recordings and then attributing them to their corresponding source neurons correctly, namely the process of spike sorting, has been prevailing so far. Support from ever-improving recording techniques and sophisticated algorithms for extracting worthwhile information and abundance in clustering procedures turned spike sorting into an indispensable tool in electrophysiological analysis.

Tracking the contribution of inductive bias to individualised internal models.

Internal models capture the regularities of the environment and are central to understanding how humans adapt to environmental statistics. In general, the correct internal model is unknown to observers, instead they rely on an approximate model that is continually adapted throughout learning. However, experimenters assume an ideal observer model, which captures stimulus structure but ignores the diverging hypotheses that humans form during learning.

Force and electromyography reflections of sensory action-effect weighting during pinching.

Ideomotor theories suggest that different action-effects are not equally important in goal-directed actions, and that task-relevant information are weighted stronger during the representation of actions. This stronger weighting of task-relevant action-effects might also enable to utilize them as retrieval cues of the corresponding motor patterns. The aim of the present study was to investigate how the consistent presence or absence of a sound action-effect influenced the retrieval of the motor components of a simple, everyday action (pinching) as reflected by the pattern of force application and surface electromyogram (sEMG) recorded from the abductor pollicis brevis (APB) and first dorsal interosseous (FDI).

The modulatory effect of adaptive task-switching training on resting-state neural network dynamics in younger and older adults.

With increasing life expectancy and active aging, it becomes crucial to investigate methods which could compensate for generally detected cognitive aging processes. A promising candidate is adaptive cognitive training, during which task difficulty is adjusted to the participants' performance level to enhance the training and potential transfer effects. Measuring intrinsic brain activity is suitable for detecting possible distributed training-effects since resting-state dynamics are linked to the brain's functional flexibility and the effectiveness of different cognitive processes.

Positive schizotypy is associated with amplified mnemonic discrimination and attenuated generalization.

Tendency to experience inaccurate beliefs alongside perceptual anomalies constitutes positive schizotypal traits in the general population and shows continuity with the positive symptoms of schizophrenia. It has been hypothesized that the positive symptomatology of schizophrenia, and by extension, the odd beliefs and unusual perceptual experiences in the general population, are associated with specific alterations in memory functions. An imbalance between memory generalization and episodic memory specificity has been proposed on several counts; however, the direction of the imbalance is currently unclear.

Thalamic activity during scalp slow waves in humans.

Slow waves are major pacemakers of NREM sleep oscillations. While slow waves themselves are mainly generated by cortical neurons, it is not clear what role thalamic activity plays in the generation of some oscillations grouped by slow waves, and to what extent thalamic activity during slow waves is itself driven by corticothalamic inputs. To address this question, we simultaneously recorded both scalp EEG and local field potentials from six thalamic nuclei (bilateral anterior, mediodorsal and ventral anterior) in fifteen epileptic patients (age-range: 17-64 years, 7 females) undergoing Deep Brain Stimulation Protocol and assessed the temporal evolution of thalamic activity relative to scalp slow waves using time-frequency analysis.

More efficient formation of longer-term representations for word forms at birth can be linked to better language skills at 2 years.

Infants are able to extract words from speech early in life. Here we show that the quality of forming longer-term representations for word forms at birth predicts expressive language ability at the age of two years. Seventy-five neonates were familiarized with two spoken disyllabic pseudowords.

The emergence of action-effect-related motor adaptation amidst outcome unpredictability.

Previous research indicates that quick, repetitive actions (pinches, taps, button presses) are executed with smaller force when followed by predictable and salient action effects (tones, light flashes). It has been suggested that successive actions become gradually softer until an optimum is reached, which presumably reflects a balance between the ability to maintain a high probability of action success, and the reduction of exerted force to conserve energy. In the present experiments, we investigated whether this appeared when the arrival of the action effect was unpredictable.

Inhibitory control hinders habit change.

Our habits constantly influence the environment, often in negative ways that amplify global environmental and health risks. Hence, change is urgent. To facilitate habit change, inhibiting unwanted behaviors appears to be a natural human reaction.

Musical training improves fine motor function in adolescents.

Background: Adolescence is a sensitive period in motor development but little is known about how long-term learning dependent processes shape hand function in tasks of different complexity.

Procedure: We mapped two fundamental aspects of hand function: simple repetitive and complex sequential finger movements, as a function of the length of musical instrumental training. We controlled maturational factors such as chronological and biological age of adolescent female participants (11 to 15 years of age, n = 114).

Neural Mechanisms Underlying the Auditory Looming Bias.

Our auditory system constantly keeps track of our environment, informing us about our surroundings and warning us of potential threats. The auditory looming bias is an early perceptual phenomenon, reflecting higher alertness of listeners to approaching auditory objects, rather than to receding ones. Experimentally, this sensation has been elicited by using both intensity-varying stimuli, as well as spectrally varying stimuli with constant intensity.

Topographical relocation of adolescent sleep spindles reveals a new maturational pattern in the human brain.

Current theories of human neural development emphasize the posterior-to-anterior pattern of brain maturation. However, this scenario leaves out significant brain areas not directly involved with sensory input and behavioral control. Suggesting the relevance of cortical activity unrelated to sensory stimulation, such as sleep, we investigated adolescent transformations in the topography of sleep spindles.

An event-related potential study of the testing effect: Electrophysiological evidence for context-dependent processes changing throughout repeated practice.

The testing effect refers to a special form of performance improvement following practice. Specifically, repeated retrieval attempts improve long-term memory. In the present study we examined the underlying mechanisms of the testing effect as a function of time by investigating the electrophysiological correlates of repeated retrieval practice.

The adolescent pattern of sleep spindle development revealed by HD-EEG.

Sleep spindles are developmentally relevant cortical oscillatory patterns; however, they have mostly been studied by considering the entire spindle frequency range (11-15 Hz) without a distinction between the functionally and topographically different slow and fast spindles, using relatively few electrodes and analysing wide age-ranges. Here, we employ high-density night sleep electroencephalography in three age-groups between 12 and 20 years of age (30 females and 30 males) and analyse the adolescent developmental pattern of the four major parameters of slow and fast sleep spindles. Most of our findings corroborate those very few previous studies that also make a distinction between slow and fast spindles in their developmental analysis.

General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons.

General anesthetics induce loss of consciousness, a global change in behavior. However, a corresponding global change in activity in the context of defined cortical cell types has not been identified. Here, we show that spontaneous activity of mouse layer 5 pyramidal neurons, but of no other cortical cell type, becomes consistently synchronized in vivo by different general anesthetics.

Bursting of excitatory cells is linked to interictal epileptic discharge generation in humans.

Knowledge about the activity of single neurons is essential in understanding the mechanisms of synchrony generation, and particularly interesting if related to pathological conditions. The generation of interictal spikes-the hypersynchronous events between seizures-is linked to hyperexcitability and to bursting behaviour of neurons in animal models. To explore its cellular mechanisms in humans we investigated the activity of clustered single neurons in a human in vitro model generating both physiological and epileptiform synchronous events.

The Evolution of Chunks in Sequence Learning.

Chunking mechanisms are central to several cognitive processes and notably to the acquisition of visuo-motor sequences. Individuals segment sequences into chunks of items to perform visuo-motor tasks more fluidly, rapidly, and accurately. However, the exact dynamics of chunking processes in the case of extended practice remain unclear.

Attachment towards the Owner Is Associated with Spontaneous Sleep EEG Parameters in Family Dogs.

Affective neuroscience studies have demonstrated the impact of social interactions on sleep quality. In humans, trait-like social behaviors, such as attachment, are related to sleep brain activity patterns. Our aim was to investigate associations between companion dogs' spontaneous brain activity during sleep (in the presence of the owner) and their relevant behavior in a task-free social context assessing their attachment towards the owner.

Evaluating ADHD Assessment for Dogs: A Replication Study.

The family dog, in its natural environment, exhibits neuropsychological deficits redolent of human psychiatric disorders, including behaviours similar to human Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms. For dogs, Vas and colleagues developed a 13-item questionnaire to measure inattention and hyperactivity/impulsivity (Dog ARS; 2007). We re-assessed, in a large sample of dogs ( = 319), psychometric properties of the Dog ARS, to identify possible limitations as a basis for further development.

Differences in dogs' event-related potentials in response to human and dog vocal stimuli; a non-invasive study.

Recent advances in the field of canine neuro-cognition allow for the non-invasive research of brain mechanisms in family dogs. Considering the striking similarities between dog's and human (infant)'s socio-cognition at the behavioural level, both similarities and differences in neural background can be of particular relevance. The current study investigates brain responses of = 17 family dogs to human and conspecific emotional vocalizations using a fully non-invasive event-related potential (ERP) paradigm.

Host cell targeting of novel antimycobacterial 4-aminosalicylic acid derivatives with tuftsin carrier peptides.

Mycobacterium tuberculosis is an intracellular pathogen and the uptake of the antimycobacterial compounds by host cells is limited. Novel antimycobacterials effective against intracellular bacteria are needed. New N-substituted derivatives of 4-aminosalicylic acid have been designed and evaluated.