The association between age-related macular degeneration and risk of Parkinson disease: A systematic review and meta-analysis.

Background: Numerous cohort studies have explored the association between age-related macular degeneration (AMD) and Parkinson disease (PD). However, a comprehensive meta-analysis on this topic is currently lacking. This study aims to address this gap by conducting a meta-analysis of existing cohort studies to investigate the relationship between AMD and the risk of developing PD.

The impact of social relationships on the risk of stroke and post-stroke mortality: a systematic review and meta-analysis.

Background: The association between poor social relationships and post-stroke mortality remains uncertain, and the evidence regarding the relationship between poor social relationships and the risk of stroke is inconsistent. In this meta-analysis, we aim to elucidate the evidence concerning the risk of stroke and post-stroke mortality among individuals experiencing a poor social relationships, including social isolation, limited social networks, lack of social support, and loneliness.

Methods: A thorough search of PubMed, Embase, and the Cochrane Library databases to systematically identify pertinent studies.

Effects and safety of preparation in the adjuvant treatment for dialysis patients: a systematic review and meta-analysis.

Ethnopharmacological Relevance: (), a genus of ascomycete fungi, has been widedly used in China as a dietary supplement or natural remedy and intensively studied in various disease models with its immunomodulatory potentials. It is a rich source of various bioactive compounds and used for treating end-stage renal disease. This systematic review with clinical evidence aimed to highlight the efficacy and safety of as an adjuvant treatment for patients undergoing dialysis.

Clinical evidence of three traditional Chinese medicine drugs and three herbal formulas for COVID-19: A systematic review and meta-analysis of the Chinese population.

Background: The coronavirus disease 2019 (COVID-19) continues to spread worldwide. Integrated Chinese and Western medicine have had some successes in treating COVID-19.

Objective: This study aims to evaluate the efficacy and safety of three traditional Chinese medicine drugs and three herbal formulas (3-drugs-3-formulas) in patients with COVID-19.

Effects and safety of Ophiocordyceps sinensis preparation in the adjuvant treatment for dialysis patients: A protocol for systematic review and meta-analysis.

Introduction: Ophiocordyceps sinensis(O. sinensis), a genus of ascomycete fungi, has been intensively studied in various disease models, which is a rich source of various bioactive compounds and used in the treatment for end-stage renal disease patients. This systematic review highlights the therapeutic roles of O.

Molecular Mechanism of the Effect of Zhizhu Pill on Gastroesophageal Reflux Disease Based on Network Pharmacology and Molecular Docking.

Background: To investigate the pharmacological mechanism of Zhizhu pill (ZZP) against gastroesophageal reflux disease (GERD), network pharmacology in combination with molecular docking was applied in this study.

Methods: Active compounds of ZZP and target genes related to GERD were identified through public databases. Subsequently, the obtained data were used as a basis for further network pharmacological analysis to explore the potential key active compounds, core targets, and biological processes involved in ZZP against GERD.

[The making method of Shen Qu in ].

Shen Qu was distiller's yeast in the most completely preserved of the ancient Chinese agricultural texts in the North Dynasty. The making process of Shen Qu (medicated leaven) in this book had far-reaching influence on the processing of Liu Shen Qu. In terms of pharmaceutical composition, Flour-qu in Shen Qu, which developed into Whole-bran-wheat-qu and then Bran-qu, is still used up to this day.

A New Strategy to Identify ceRNA-Based CCDC144NL-AS1/SERPINE1 Regulatory Axis as a Novel Prognostic Biomarker for Stomach Adenocarcinoma High Throughput Transcriptome Data Mining and Computational Verification.

Stomach adenocarcinoma (STAD) is one of the most malignant cancers that endanger human health. There is growing evidence that competitive endogenous RNA (ceRNA) regulatory networks play an important role in various human tumors. However, the complexity and behavioral characteristics of the ceRNA network in STAD are still unclear.

Hanshiyi Formula, a medicine for Sars-CoV2 infection in China, reduced the proportion of mild and moderate COVID-19 patients turning to severe status: A cohort study.

We formulated a traditional Chinese medicine (TCM) prescription, Hanshiyi Formula (HSYF), which was approved and promoted by the Wuhan Municipal Health Commission for treating mild and moderate coronavirus disease 2019 (COVID-19). We aimed to evaluate the effect of HSYF on the progression to severe disease in mild and moderate COVID-19 patients. We conducted a retrospective cohort study of patients with mild and moderate COVID-19 in a quarantine station in Wuchang District, Wuhan.

[Research status and development strategies of moxibustion standardization].

Based on the analysis of the present situation of standardization of moxibustion, it is found that the published standards of acupuncture and moxibustion are predominated at acupoint standard and acupuncture manipulation standard. Moxibusiton standardization mainly focuses on the manipulation. It is relatively lack of the standards of moxibustion materials and device.

[Compound matrine injection reduces morphine tolerance of the mice with lung cancer by inhibiting expression of multidrug resistance gene 1 and P-glycoprotein].

To investigate the effect of compound matrine injection on morphine tolerance in mice with lung cancer in situ and the expressions of multidrug resistance gene 1 (MDR1) and P-glycoprotein (P-gp). A mouse model of lung cancer in situ and morphine tolerance mode was established. The mice were injected with gradient concentration of compound matrine.

Microbiome and metabonomics study of quercetin for the treatment of atherosclerosis.

Background: The molecular mechanism of quercetin in the prevention and treatment of AS has been widely reported. However, the microbial and metabolic characteristics of quercetin in AS treatment are still poorly understood. In this study, we aimed to explore the gut microbial and metabolic signatures of quercetin in AS treatment and conduct an integrative analysis on its biomechanism.

Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation.

Numerous studies have examined the pathogenesis of osteoporosis. The causes of osteoporosis include endocrine factors, nutritional status, genetic factors, physical factors, and immune factors. Recent osteoimmunology studies demonstrated that the immune system and immune factors play important regulatory roles in the occurrence of osteoporosis, and people should pay more attention to the relationship between immunity and osteoporosis.

[Visualization analysis of CiteSpace knowledge map for lumbar disc herniation treated with acupuncture and moxibustion].

Objective: To analyze the researches of acupuncture and moxibustion for lumbar disc herniation (LDH) in recent 15 years and summarize the research direction and collect the knowledge structure.

Methods: The relevant literature on acupuncture and moxibustion for the treatment of LDH was retrieved from CNKI. After Refworks format reversion, the CiteSpace software was used to create the reproductive map of the authors, research institutions and keywords in the literature on acupuncture and moxibustion for LDH.

[Clinical value evaluation of Chinese herbal formula in context of multi-omics network].

Clinical value evaluation is the key issue to solve the problems such as high repetition rate, fuzzy clinical positioning, broad indications and unclear clinical values in Chinese herbal formula(Chinese patent medicine). By analyzing the challenges and opportunities of Chinese herbal formula in clinical value evaluation, this paper introduced a strategy of multi-omic network analysis. Through comparative analysis of three stroke treatment formulas, we suggested their different characteristic advantages for variant symptoms or phenotypes of stroke, which may provide reference for rational clinical choice.

Effects of Mahuang (Herba Ephedra Sinica) and Wuweizi (Fructus Schisandrae Chinensis) medicated serum on chemotactic migration of alveolar macrophages and inters regions macrophages in rats.

Objective: To observe the effects of serum containing Mahuang (Herba Ephedra Sinica) or Wuweizi (Fructus Schisandrae Chinensis) on the migration of alveolar macrophages (AM) and interstitial macrophages (IM) from normal rats, and to analyze and compare the mechanisms leading to cell migration differences.

Methods: Rats were randomly divided into three groups: Mahuang (Herba Ephedra Sinica), Wuweizi (Fructus Schisandrae Chinensis), and blank serum. After treatment with the herbs, serum was extracted from the rats.

Effect of GAPT extract on expression of tau protein and its phosphorylation related enzymes in hippocampal neurons of APPV717I transgenic mice.

Objective: To investigate the effect of GAPT, an extract mixture from Radix Ginseng, Rhizoma Acor tatarinowii, Radix Polygalae and Radix Curcuma (containing ingredient of turmeric), etc. on expression of tau protein and its phosphorylation related enzyme in hippocampal neurons of APPV717I transgenic mice.

Methods: Sixty three-month-old APPV717I transgenic mice were randomly divided into model group, donepezil group [0.

[Thinking on risk assessment and risk management of post-marketing Chinese medicine].

Drug risk assessment and management is an important measure for reducing the adverse drug reaction and enhancing medication safety of the patient. Based on the concepts of drug risk assessment and risk management, and domestic and international drug risk management situation, this paper discusses the risk management of post-marketing Chinese medicine.

[Patient-reported outcomes: advances in research and practical application].

Clinical evaluation proceedings from patient-reported outcomes (PRO) are being concerned increasingly. Based on the concept of PRO, the report discusses the findings in the research recently made at home and abroad. PRO from apoplexy patients with spastic paralysis was taken as an example in the exploration of how to evaluate the curative effects in clinical practice on the basis of PRO.

[Contributions of professor Xue Chong-cheng in acupuncture and neuropsychiatry].

Professor Xue Chong-cheng devotes himself in clinical and research of integrative works of TCM, acupuncture, neuropsychiatry, neurosurgery and medicopsychology for more than 70 years. He firstly confirmed acupoints are identical with nerve and motor points, found propagating meridian sensation on phantom limbs of acquired and congenital amputates. The sensation can pass over fresh incision wound and it exits and disappears with the cortical sensation.

[Application of qualitative interviews in clinical research of traditional Chinese medicine].

Qualitative interview can collect data independently and can help modify and explain data when being combined with the quantitative research. The authors of this article introduced some kinds of qualitative interviews and their application in clinical research of traditional Chinese medicine (TCM). It emphasized some aspects of qualitative interview including the origin and definition, classification, basic standards, sampling, data analysis and report writing, quality evaluation and application for TCM clinical research.