Conformer-Mediated Helical Chirality in 2D Layered Hybrid Perovskites.

Two-dimensional (2D) chiral hybrid perovskites APbI (A: chiral organic ion) enable chirality controlled optoelectronic and spin-based properties. A organic sublattice induces chirality into the semiconducting [PbI] inorganic sublattice through non-covalent interactions at organic-inorganic interface. Often, the A cations in the lattice have different orientations, leading to asymmetry in the non-covalent interactions.

Structural and optical studies of fluoride ion binding using N-heteroaromatic ligands.

8-Hydroxyquinoline and imidazole, two important N-heteroaromatic systems, have a strong affinity towards various anions their acidic OH or NH protons. Three receptor ligands, 5-(1-benzo[]imidazol-2-yl)quinolin-8-ol (1), 5-(benzo[]thiazol-2-yl)quinolin-8-ol (2), and 4-(1-benzo[]imidazol-2-yl)benzene-1,3-diol (3), were synthesized, and their fluoride (F) ion binding properties were investigated. These ligands could selectively bind F ions, and their respective F complexes, namely, 1-TBAF, 2-TBAF, and 3-TBAF (TBAF = tetrabutylammonium fluoride), were characterized using single crystal X-ray analysis, NMR, UV-vis, Hirshfeld surface (HS) analysis and computational studies.

Enhanced two-photon absorption in hydrothermally synthesized LaOTe nanorods for visible light photodetection.

In the present study, lanthanum oxytellurate (LOT) samples with varying La : Te ratios are successfully synthesized using a simple hydrothermal method that has enormous advantages. The prepared samples crystallize in a LaOTe composite phase with an orthorhombic crystal system. A nanorod-like morphology is observed for each sample, and the presence of constituent elements is verified from EDX results.

Strategies To Achieve Long-Term Stability in Lead Halide Perovskite Nanocrystals and Its Optoelectronic Applications.

The lead halide perovskite (LHP) nanocrystals (NCs) research area is flourishing due to their exceptional properties and great potential for a wide range of applications in optoelectronics and photovoltaics. Yet, despite the momentum in the field, perovskite devices are not yet ready for commercialization due to degradation caused by intrinsic phase transitions and external factors such as moisture, temperature, and ultraviolet (UV) light. To attain long-term stability, we analyze the origin of instabilities and describe different strategies such as surface modification, encapsulation, and doping for long-term viability.

Intrinsic physiochemical insights to green synthesized Ag-decorated GO nanosheet for photoluminescence and in vivo cellular biocompatibility with embryonic zebrafish.

The advancement of nanotechnology and their application has intrigued a significant interest in green synthesis and application of organic and inorganic nanomaterials like graphene oxide (GO) and silver nanoparticles (AgNP). This study explores the intrinsic physiochemical properties of silver (Ag)-decorated graphene oxide (GO) nanosheets synthesized via a green approach, focusing on their photoluminescence behaviour and in vivo cellular biocompatibility with embryonic zebrafish. The nanocomposites were characterized using various spectroscopic and microscopic techniques to elucidate their structural and optical properties.

Hydrothermally Synthesized Bi-Doped CdTe Nanoparticles with Tunable Optical and Photoresponse Properties for Visible Photodetectors.

The remarkable applicability and unique properties of CdTe nanoparticles make them vital in various applications such as optoelectronics and photovoltaics. It has been demonstrated that adding a metal dopant to a nanomaterial matrix significantly improves its characteristics, increasing its potential for a variety of applications. In this work, a simple hydrothermal synthesis process for bidoped CdTe nanoparticles is reported, wherein four distinct samples are generated by adjusting the concentration of Bi doping.

Cu(II)/PTABS-Promoted, Chemoselective Amination of HaloPyrimidines.

Chemoselective amination is a highly desired synthetic methodology, given its importance as a possible strategy to synthesize various drug molecules and agrochemicals. We, herein, disclose a highly chemoselective Cu(II)-PTABS-promoted amination of pyrimidine structural feature containing different halogen atoms.

Rapid microwave-assisted synthesis and characterization of a novel CuCoTe nanocomposite material for optoelectronic and dielectric applications.

In the realm of nanomaterial research, copper telluride and cobalt telluride have individually attracted considerable attention owing to their unique properties and potential applications. However, there exists a notable gap in the literature when it comes to the exploration of composite materials derived from these elements. From this point of view, a ternary CuCoTe nanocomposite was prepared using the microwave synthesis method.

Four component Ugi reaction based small-molecule probes for integrated phenotypic screening.

Quorum-sensing (QS) is a cell density-dependent signaling pathway regulated by gene expression for intra- and interspecies communication. We have targeted QS activity in Pseudomonas aeruginosa, an opportunistic human pathogen that causes disease in immunocompromised patients, with a set of probes containing a variety of functional groups, including photoreactive (diazirine) and affinity (alkyne) moieties, that were synthesized using a four-component Ugi reaction (Ugi-4CR).

Exploring optical, electrochemical, thermal, and theoretical aspects of simple carbazole-derived organic dyes.

This study highlights the recent advancements in organic electronic materials and their potential for cost-effective optoelectronic devices. The investigation focuses on the molecular design, synthesis, and comprehensive analysis of two organic dyes, aiming to explore their suitability for optoelectronic applications. The dyes are strategically constructed with carbazole as the foundational structure, connecting two electron-withdrawing groups: barbituric acid () and thiobarbituric acid ().

Reductive dimerization of benzothiazolium salts.

Three different types of reaction products were obtained from the reduction of 2-substituted 3-methylbenzothiazolium salts using Na : Hg (1 wt%). Depending on the 2-substituents, two types of dimeric compounds were obtained: the 2-cyclohexyl-, 2-phenyl-, and 2-(-tolyl)-substituted species are reduced to the corresponding 2,2'-bibenzo[]thiazoles, while their 2-((-OMe)CH)- and 2-((-NMe)CH)-substituted derivatives afford -[1,4]benzothiazino[3,2-][1,4]benzothiazines. Furthermore, in the presence of molecular O, new disulfide derivatives were obtained from the bibenzo[]thiazoles.

Copper-catalysed chemoselective C-OH bond activation of -benzoyl cytosine: facile access to 2-(dimethylamino)pyrimidine.

A novel method for the direct amination of -benzoyl cytosine has been developed, giving access to 2-(dimethylamino)pyrimidine derivatives. A copper(II) catalyst and -butyl hydroperoxide easily promote the selective amination process that proceeds C-OH bond activation. This practical approach can utilize different formamide molecules, ,-dimethylformamide and ,-diethylformamide, as efficient amino (-NMe, -NEt) sources.

DMSO-Assisted K PO -Catalyzed Cooperative Metal-Free, Base-Free Etherification of Chloroheteroarenes at Low Temperature.

Etherification of chloroheteroarenes was performed at low temperatures under metal-free, ligand-free and base-free conditions, that is, the reaction is promoted by the cooperative effect of DMSO (solvent) as a promoter and K PO providing the catalytic surface (rather than a base). The protocol exhibits good substrate scope under mild reaction conditions and has also been explored mechanistically.

Zinc-catalyzed transamidation and esterification of -benzoyl cytosine C-N bond cleavage.

We have utilized -benzoyl cytosine for efficient transamidation and esterification catalytic C-N bond cleavage. The one-pot strategy involves the reaction of secondary amide with various aliphatic or aromatic amines and alcohols in the presence of zinc triflate and DTBP, affording diverse amides and esters in excellent yields.

Room-Temperature Dialkylamination of Chloroheteroarenes Using a Cu(II)/PTABS Catalytic System.

The dimethylamino functionality has significant importance in industrially relevant molecules and methodologies to install these efficiently are highly desirable. We report herein a highly efficient, room-temperature dimethylamination of chloroheteroarenes performed via the in-situ generation of dimethylamine using N,N-dimethylformamide (DMF) as precursor wiith a large substrate scope that includes various heteroarenes, purines as well as commercially relevant drugs such as altretamine, ampyzine and puromycin precursor.

Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil.

Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts.

Quadrol-Pd(II) complexes: phosphine-free precatalysts for the room-temperature Suzuki-Miyaura synthesis of nucleoside analogues in aqueous media.

Commercially available Quadrol, ,,','-tetrakis(2-hydroxypropyl)ethylenediamine (THPEN), has been used for the first time as a N^N-donor neutral hydrophilic ligand in the synthesis and characterization of new water soluble palladium(II) complexes containing chloride, phthalimidate or saccharinate as co-ligands. [PdCl(THPEN)] (1) [Pd(phthal)(THPEN)] (2), [Pd(sacc)(THPEN)] (3) and the analogous complex with the closely related ,,','-tetrakis(2-hydroxyethyl)ethylenediamine (THEEN) [Pd(sacc)(THEEN)] (4) were efficiently prepared in a one-pot reaction from [PdCl(CHCN)] or Pd(OAc). Structural characterization of 1 and 3 by single crystal X-ray diffraction produced the first structures reported to date of palladium complexes with Quadrol.

Room temperature HFIP/Ag-promoted palladium-catalyzed C-H functionalization of benzothiazole with iodoarenes.

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodoarenes under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted selective iodination of arenes followed by Pd-catalyzed direct arylation of benzothiazole has also been disclosed. The utility of the developed protocol has been demonstrated by the synthesis of anti-tumor agents, PMX-610 and CJM-126 (precursor).

Room-Temperature Amination of Chloroheteroarenes in Water by a Recyclable Copper(II)-Phosphaadamantanium Sulfonate System.

Buchwald-Hartwig amination of chloroheteroarenes has been a challenging synthetic process, with very few protocols promoting this important transformation at ambient temperature. The current report discusses about an efficient copper-based catalytic system (Cu/PTABS) for the amination of chloroheteroarenes at ambient temperature in water as the sole reaction solvent, a combination that is first to be reported. A wide variety of chloroheteroarenes could be coupled efficiently with primary and secondary amines as well as selected amino acid esters under mild reaction conditions.

Carbon dioxide based methodologies for the synthesis of fine chemicals.

Rapid environmental changes triggered by the increase in the concentration of heat-absorbing gases such as CO2 in the atmosphere have become a major cause of concern. One of the ways to counter this growing threat will be to efficiently convert atmospheric CO2 into value-added products via the development of efficient transition-metal-catalyzed processes. Conversion of CO2 into bulk products such as CH3OH and methane as well as its incorporation into commercial polyurethane synthesis has been achieved and reviewed extensively.

Tandem Homometallic or Multimetallic Catalysis for Assembly of Base-Modified Nucleosides.

Tandem catalysis has been at the forefront of synthesis in the past decade due to the reduction in the number of steps and purification needed for the synthesis of commercially relevant molecules. With the right combination of catalyst systems, which could be homometallic or multimetallic, one can construct complex structural motifs in a one-pot procedure without the requirement for the isolation of the intermediates, reducing both reagent waste and time. Over the years, application of tandem catalysis has certainly extended towards arene and heteroarene motifs; nucleoside modification using such a strategy has been rare.

Seasonal Nutritional Food Security to Indian Women through Community-level Implementation of Domestic Solar Conduction Dryer.

This study explores the impact of a house-hold, post-harvest processing unit on the nutritional, economic, and social status of rural women. Solar Conduction Dryer (SCD) is an electricity-free, solar-powered food dehydrator for the production of dried vegetables, fruits, marine, and meat-based products. SCD was provided to 200 rural women farmers in the Aurangabad district of India.

Discovery, Synthesis, and Scale-up of Efficient Palladium Catalysts Useful for the Modification of Nucleosides and Heteroarenes.

Nucleic acid derivatives are imperative biomolecules and are involved in life governing processes. The chemical modification of nucleic acid is a fascinating area for researchers due to the potential activity exhibited as antiviral and antitumor agents. In addition, these molecules are also of interest toward conducting useful biochemical, pharmaceutical, and mutagenic study.

HFIP Promoted Low-Temperature SAr of Chloroheteroarenes Using Thiols and Amines.

A highly efficient and an unprecedented hexafluoro-2-propanol, promoting low-temperature aromatic nucleophilic substitutions of chloroheteroarenes, has been performed using thiols and (secondary) amines under base-free and metal-free conditions. The developed protocol also provides excellent regio-control for the selective functionalization of dichloroheteroarenes, while the utility of the protocol was demonstrated by the modification of a commercially available drug ceritinib.