Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?

Βradykinin stimulation of B2 receptor is known to activate the oncogenic ERK pathway and overexpression of bradykinin receptors B1 and B2 has been reported to occur in glioma, colorectal and cervical cancers. B1R and B2R antagonists have been shown to reverse tumor proliferation and invasion. Paradoxically, B1R and B2R agonism has also been reported to elicit antiproliferative benefits.

Outstanding Broadband (532 nm to 2.2 μm) and Very Efficient Optical Limiting Performance of Some Defect-Engineered Graphenes.

Graphene derivatives and defect-engineered graphenes have attracted the interest of researchers owing to the excellent and tunable properties they exhibit. In this work the optical limiting performance of two defect-engineered boron- and nitrogen-doped reduced graphene oxides is investigated. Both graphenes are found to exhibit exceptional and broadband optical limiting action ranging from 532 to 2200 nm.

Mechanical, Electrical, and Thermal Properties of Carbon Nanotube Buckypapers/Epoxy Nanocomposites Produced by Oxidized and Epoxidized Nanotubes.

High volume fraction carbon nanotube (CNT) composites (7.5-16% vol.) were fabricated by the impregnation of CNT buckypapers into epoxy resin.

Asymmetric Dinuclear Lanthanide(III) Complexes from the Use of a Ligand Derived from 2-Acetylpyridine and Picolinoylhydrazide: Synthetic, Structural and Magnetic Studies.

A family of four Ln(III) complexes has been synthesized with the general formula [Ln(NO)(L)(S)] (Ln = Gd, Tb, Er, and S = HO; , and , respectively/Ln = Dy, S = MeOH, complex ), where HL is the flexible ditopic ligand '-(1-(pyridin-2-yl)ethylidene)pyridine-2-carbohydrazide. The structures of isostructural MeOH/HO solvates of these complexes were determined by single-crystal X-ray diffraction. The two Ln ions are doubly bridged by the deprotonated oxygen atoms of two "head-to-head" 2.

On the Ferroelectric to Paraelectric Structural Transition of BaTiO Micro-/Nanoparticles and Their Epoxy Nanocomposites.

BaTiO is one of the most widely used ceramic components in capacitor formulation due to its exceptional ferroelectric properties. The structural transition from the ferroelectric tetragonal to the paraelectric cubic phase has been studied in both nano- and micro-BaTiO particles. Several experimental techniques were employed for characterization purposes (X-ray diffraction-XRD, laser Raman spectroscopy-LRS, differential scanning calorimetry-DSC and broadband dielectric spectroscopy-BDS).

Pretreatment of used disposable nappies: Super absorbent polymer deswelling.

Typical used disposable nappies usually consist of nonwoven fabrics, Super Absorbent Polymer (SAP), and organic material, namely fluffy pulp, urine and/or excreta. Currently, this waste stream is being disposed to landfills causing many environmental issues. An alternative management method could be the valorisation of the biodegradable material through anaerobic digestion, and the recycling of plastics and SAP.

Two-step treatment of brewery wastewater using electrocoagulation and cyanobacteria-based cultivation.

This study combines electrocoagulation (EC) and cyanobacteria-based cultivation for the two-step treatment of brewery wastewater (BW), with the aim to develop a viable alternative to conventional activated sludge technology. The first step applied EC as a pretreatment method, using different electrode materials (aluminum and iron), to remove color and some pollutant load from the BW. After 30 min of EC treatment, decolorization of BW exceeded 80% for both electrode materials and a 100% reduction of total suspended solids was achieved.

Polymeric Coatings Based on Water-Soluble Trimethylammonium Copolymers for Antifouling Applications.

Crosslinked polymeric materials based on a quaternary trimethylammonium compound were developed and evaluated as potential antifouling coatings. For this purpose, two water-soluble random copolymers, poly(4-vinylbenzyltrimethylammonium chloride-co-acrylic acid) P(VBCTMAM-co-AAx) and poly(N,N-dimethylacrylamide-co-glycidylmethacrylate) P(DMAm-co-GMAx), were synthesized via free radical polymerization. A water based approach for the synthesis of P(VBCTMAM-co-AAx) copolymer was used.

Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing.

Clinical translation of cell-based products is hampered by their limited predictive in vivo performance. To overcome this hurdle, engineering strategies advocate to fabricate tissue products through processes that mimic development and regeneration, a strategy applicable for the healing of large bone defects, an unmet medical need. Natural fracture healing occurs through the formation of a cartilage intermediate, termed "soft callus," which is transformed into bone following a process that recapitulates developmental events.

Thiophenol-Modified Fluorographene Derivatives for Nonlinear Optical Applications.

The synthesis and characterization of two thiophenol-modified fluorographene derivatives, namely methoxythiophenol-and dimethylaminothiophenol-modified fluorographenes, are reported, while their third-order nonlinear optical response were thoroughly investigated under both visible (532 nm) and infrared (1064 nm) with 35 ps and 4 ns laser pulses. The graphene derivatives were obtained by partial nucleophilic substitution/reduction of fluorographene by the corresponding organic thiophenols, and were fully characterized by techniques including infrared/Raman spectroscopy, X-ray photoelectron spectroscopy, atomic force spectroscopy, and high-resolution transmission microscopy. This type of modification resulted in graphenic structures where the attached thiol groups, sp domains, and the residual fluorine groups act as donors, π bridges, and acceptors, respectively.

Three-Dimensional Digital Reconstruction of TiAlC Ceramic Foams Produced by the Gelcast Method.

Α digital reconstruction technique is presented that generates three-dimensional (3D) digital representations of ceramic foams created by the foam-gelcasting technique. The reconstruction process uses information that is directly extracted from Scanning Electron Microscopy (SEM) images and offers a 3D representation of the physical sample accounting for the typically large pore cavities and interconnecting windows that are formed during the preparation process. Contrary to typical tessellation-based foam treatments, a spherical representation of the pores and the pore windows of the foams is assumed and a novel hybrid algorithm that combines a variation of Lubachevsky-type and Random Close Packing of Hard Spheres (RCPHS) algorithms has been developed to obtain near-optimum solutions to the packing problem of the spheres that represent the pores.

Modification of Collagen Derivatives with Water-Soluble Polymers for the Development of Cross-Linked Hydrogels for Controlled Release.

Novel cross-linked hydrogels were synthesized as potential materials for the development of smart biofertilizers. For this purpose, hydrogels were prepared using collagen hydrolysate recovered from tannery waste. The water-soluble polymer poly(sodium 4-styrenesulfonate-co-glycidyl methacrylate) (P(SSNa-co-GMAx)) was among others used for the cross-linking reaction that combined hydrophilic nature with epoxide groups.

Tetranuclear oxido-bridged thorium(iv) clusters obtained using tridentate Schiff bases.

Thorium(iv) complexes are currently attracting intense attention from inorganic chemists due to the development of liquid-fluoride thorium reactors and the fact that thorium(iv) is often used as a model system for the study of the more radioactive Np(iv) and Pu(iv). Schiff-base complexes of tetravalent actinides are useful for the development of new separation strategies in nuclear fuel processing and nuclear waste management. Thorium(iv)-Schiff base complexes find applications in the colorimetric detection of this toxic metal ion and the construction of fluorescent on/off sensors for Th(iv) exploiting the ligand-based light emission of its complexes.

Laser-based classification of olive oils assisted by machine learning.

Olive oil is an essential diet component in all Mediterranean countries having a considerable impact on the local economies, which are producing almost 90% of the world production. Therefore, the quality assessment of olive oil in terms of its acidity and its authentication in terms of PDO (Protected Designation of Origin) and PGI (Protected Geographical Indications) characterizations are nowadays necessary and of great importance for the market of olive oil and the related economic activities. In the present work, Laser Induced Breakdown Spectroscopy (LIBS) is used assisted by machine learning algorithms for retrieving of the information contained in the LIBS spectra to provide a simple, reliable, and ultrafast methodology for olive oils classification in terms of the degree of acidity and geographical origin.

Extracellular matrix: key structural and functional meshwork in health and disease.

The extracellular matrix (ECM) is a multifunctional 3D network of interconnected macromolecules that mediate cellular responses in normal and pathological conditions, including wound healing, tissue homeostasis, skeletal and cardiovascular disease, cancer and drug resistance. The potential of targeting ECM components, such as proteoglycans and glycosaminoglycans, matrix-degrading enzymes and miRNAs will serve as a novel tool for innovative diagnostic methods and therapeutic strategies. With this Special Issue on Extracellular Matrix in Health and Disease, The FEBS Journal offers an updated overview of the functional properties and biological roles of several ECM components, highlighting the significance of ECM targeting in disease management.

Estrogen receptor-mediated targeting of the extracellular matrix network in cancer.

The biological functions of estrogens are regulated by estrogen receptors (ERα and ERβ), which contribute in the progression of several hormone-responsive cancer types via estrogen signaling mechanisms. The coordinated actions of ERs and extracellular matrix (ECM) macromolecules are principal mediators of ECM remodeling in the tumor and the adjacent stroma. In breast cancer, ERs are critical biomarkers as their expression in breast tumor determines the disease-free survival, yet guiding treatment decisions and predicting prognosis as well as response to endocrine therapy.

Dynamic Interplay between miRNAs and the Extracellular Matrix Influences the Tumor Microenvironment.

Expression of miRNAs is critical for the regulation of several cell functions including proliferation, migration, differentiation, and survival, as well as extracellular matrix (ECM) remodeling. The dynamic interplay between miRNAs, ECM macromolecules, and the tumor microenvironment plays critical roles in many aspects of human diseases such as metabolic disorders and cancers. Circulating and secreted miRNAs, via membrane vesicles, affect cell-cell communication and cellular metabolic pathways, underscoring their significance in tumor progression.

Modeling the Solvent Extraction of Cadmium(II) from Aqueous Chloride Solutions by 2-pyridyl Ketoximes: A Coordination Chemistry Approach.

The goal of this work is to model the nature of the chemical species [CdCl(extractant)] that are formed during the solvent (or liquid-liquid) extraction of the toxic cadmium(II) from chloride-containing aqueous media using hydrophobic 2-pyridyl ketoximes as extractants. Our coordination chemistry approach involves the study of the reactions between cadmium(II) chloride dihydrate and phenyl 2-pyridyl ketoxime (phpaoH) in water-containing acetone. The reactions have provided access to complexes [CdCl(phpaoH)]∙HO (∙HO) and {[CdCl(phpaoH)]} (); the solid-state structures of which have been determined by single-crystal X-ray crystallography.

Food residue biomass product as an alternative fuel for the cement industry.

The present study focuses on the production of an alternative fuel (AF) for the cement industry from a food residue biomass (FORBI) product, generated from pre-sorted household food waste (HFW). FORBI is generated by drying and shredding the fermentable fraction of HFW collected door-to-door in the Municipality of Halandri, Greece. The key physicochemical properties such as the net calorific value (NCV), and the concentration of heavy metals and chlorine are subsequently determined using well-established international standards (EN and ISO).

Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease.

Multiple thioredoxin isoforms exist in all living cells. To explore the possible functions of mammalian mitochondrial thioredoxin 2 (Trx2), an interactome of mouse Trx2 was initially created using (i) a monothiol mouse Trx2 species for capturing protein partners from different organs and (ii) yeast two hybrid screens on human liver and rat brain cDNA libraries. The resulting interactome consisted of 195 proteins (Trx2 included) plus the mitochondrial 16S RNA.

Advanced Laguerre Tessellation for the Reconstruction of Ceramic Foams and Prediction of Transport Properties.

Ceramic foams are promising, highly porous materials, with a wide range of specific surface area and low fluid flow resistance, which are well-suited for filtering applications. They are comprised mainly of macrovoids that are interconnected with struts. A branch-shaped reconstruction algorithm is introduced in the present work to reconstruct various ceramic foams from electron microscopy images using the Laguerre tessellation method.

A Known Iron(II) Complex in Different Nanosized Particles: Variable-Temperature Raman Study of Its Spin-Crossover Behavior.

The spin-crossover (SCO) polymorph B (complex 1) of the known compound [Fe{N(CN)}(abpt)], where abpt is 4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole, has been prepared in three different particle sizes averaging ∼300 (sample 1a), ∼80 (sample 1b), and ∼20 nm (sample 1c). Two independent octahedral molecules possessing Fe1 and Fe2 were found to be present in the crystal of B. Magnetostructural relationships had established that at room temperature both Fe sites are in the high-spin state (HS-HS), whereas a decrease in the temperature to 90 K induces the complete high-spin to low-spin conversion of the Fe1 site, with Fe2 remaining in the high-spin state (LS-HS).

Treatment of printing ink wastewater using electrocoagulation.

The present study investigates the treatment of real printing ink wastewater by using the electrocoagulation (EC) process. Effects of initial chemical oxygen demand (COD) concentrations, electrode materials and current densities were examined to determine the maximum COD and color removal from the wastewater. In parallel, raw and treated printing ink wastewater toxic potential was further estimated via the application of toxicity tests using the freshwater crustacean Thamnocephalus platyurus for assessing EC process efficiency.

Hyaluronan: molecular size-dependent signaling and biological functions in inflammation and cancer.

Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that plays a pivotal role in a variety of biological processes. High-molecular weight HA exhibits different biological properties than oligomers and low-molecular weight HA. Depending on their molecular size, HA fragments can influence cellular behavior in a different mode of action.

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.

The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural network comprised of macromolecules, such as proteoglycans/glycosaminoglycans (PGs/GAGs), collagens, laminins, fibronectin, elastin, other glycoproteins and proteinases. In recent years, the field of PGs has expanded rapidly. Due to their high structural complexity and heterogeneity, PGs mediate several homeostatic and pathological processes.