2 results match your criteria: "Institute of Cellular and Organismic Biology and Neuroscience Program of Academia Sinica[Affiliation]"
Enhancing social behavior in an autism spectrum disorder mouse model: investigating the underlying mechanisms of intervention.
Gut Microbes
June 2024
Institute of Cellular and Organismic Biology and Neuroscience Program of Academia Sinica, Academia Sinica, Taipei, Taiwan.
Article Synopsis
- Autism spectrum disorder (ASD) affects over 1% of the global population, causing social difficulties and repetitive behaviors, often alongside other conditions like anxiety.
- Research on mice exposed to valproic acid (VPA) as a prenatal factor suggests that the probiotic PS128 may improve behavioral symptoms in ASD by restoring dendritic structure and oxytocin levels.
- These findings point to PS128’s potential in altering gut microbiota and supporting the development of new therapies for ASD.
ICA69 regulates activity-dependent synaptic strengthening and learning and memory.
Front Mol Neurosci
May 2023
Solomon H. Snyder Department of Neuroscience and Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Long-term potentiation (LTP) is one of the major cellular mechanisms for learning and memory. Activity-dependent increases in surface AMPA receptors (AMPARs) are important for enhanced synaptic efficacy during LTP. Here, we report a novel function of a secretory trafficking protein, ICA69, in AMPAR trafficking, synaptic plasticity, and animal cognition.
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