1 results match your criteria: "Institute of Cell Biophysics of Russian Academy Science[Affiliation]"
Inhibitors of TLR-4, NF-κB, and SAPK/JNK signaling reduce the toxic effect of lipopolysaccharide on RAW 264.7 cells.
J Immunotoxicol
December 2013
Institute of Cell Biophysics of Russian Academy Science, Institutskaja Street 3, Pushchino, Moscow Region, Russia.
Article Synopsis
- The study investigates the impact of three specific inhibitors on the cytokine response in macrophages, observing both the synthesis of heat shock proteins and activities of certain signaling pathways.
- Pre-treatment with these inhibitors before exposure to E. coli lipopolysaccharide (LPS) resulted in reduced production of inflammatory molecules like TNF-α, IL-1, and IFN-γ, as well as a decrease in TLR4 expression and signaling pathway activation.
- Among the inhibitors tested, IKK inhibitor XII showed the most promise in effectively suppressing inflammation and holds potential as an anti-toxic agent.