26,785 results match your criteria: "Institute of Biotechnology[Affiliation]"
Pharmacol Res
December 2024
Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350401, Taiwan. Electronic address:
The large and rapid increase in the incidence and mortality of colorectal cancer (CRC) demonstrates the urgent need for new drugs with higher efficacy to treat CRC. However, the lack of applicable and reliable preclinical models significantly hinders the progress of drug development. Patient-derived xenograft (PDX) models are currently considered reliable in vivo preclinical models for predicting drug efficacy in cancer patients.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Key Laboratory of Crop Diseases and Insect Pests of Ministry of Agriculture and Rural Affairs, Institute of Biotechnology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, People's Republic of China; Zhejiang Provincial Key Laboratory of Biology of Crop Pathogens and Insects, Institute of Biotechnology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, People's Republic of China; State Key Laboratory of Rice Biology and Breeding, Institute of Biotechnology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, People's Republic of China. Electronic address:
Poly(ADP-ribosyl)ation (PARylation), catalyzed by poly(ADP-ribose) polymerases (PARPs) and hydrolyzed by poly(ADP-ribose) glycohydrolase (PARG), is an important reversible post-translational protein modification in all eukaryotes, including plant pathogenic fungi. Previously, we revealed that FonPARP1, an active PARP, is crucial for the pathogenicity of Fusarium oxysporum f. sp.
View Article and Find Full Text PDFProtist
December 2024
C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Maliba Campus, Bardoli, Surat 394 350, Gujarat, India. Electronic address:
Reclamation of petroleum-polluted environments is a key issue for today and in the future, as our reliance on oil will persist for decades. An eco-friendly solution is to use microbes that play a role in petroleum-hydrocarbon degradation. However, as hydrocarbon degradation involves a multi-step process involving different functional groups, focusing only on finding efficient bacterial species will not be the complete solution.
View Article and Find Full Text PDFFood Chem
December 2024
Amity Institute of Biotechnology, Amity University, Jaipur, Rajasthan, India. Electronic address:
The research on the foaming of semi-solid gel (oleogel) has recently attracted the attention of food scientists owing to its functional characteristics that make it a potential alternative to saturated fat and trans-fat used in food products. The oleofoams are prepared by heating the vegetable oil with an oleogelator followed by cooling to form a semi-solid gel and then incorporating air in the semi-solid gel to form an air-in-oil system having higher stability to deformation. Oleofoams provide new opportunities for the development of novel aerated food products free of saturated and trans fatty acids to meet the growing demand of consumers for healthy foods.
View Article and Find Full Text PDFRes Vet Sci
December 2024
Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh. Electronic address:
The recent outbreak of lumpy skin disease virus (LSDV) in the wetland areas of Bangladesh presents a significant concern for both animal health and regional biosecurity. Epidemiological investigations into nine major outbreaks in the wetland areas revealed distinctive clinical symptoms in affected cattle, including elevated body temperature, excessive salivation, and the presence of skin nodules. Histopathological examination unveiled larger nodules compared to previous outbreaks, along with signs of secondary infection.
View Article and Find Full Text PDFInt Microbiol
December 2024
Department of Biological and Chemical Engineering, USCR Molecular Bacteriology and Genomics, National Institute of Applied Science and Technology, University of Carthage, 1080, Tunis Cedex, Tunisia.
This study re-evaluates Pseudofrankia strains, traditionally regarded as parasitic dwellers of actinorhizal root nodules due to their inability to fix nitrogen (Fix -) and/or nodulate (Nod -), as potential plant growth-promoting bacteria (PGPB). We compared plant growth-promoting traits (PGPTs) between Pseudofrankia strains, including one newly sequenced strain BMG5.37 in this study and typical (Fix + /Nod +) Frankia, Protofrankia, and Parafrankia, as well as non-frankia actinorhizal species Nocardia and Micromonospora, and the phytopathogenic Streptomyces.
View Article and Find Full Text PDFJ Biol Chem
December 2024
SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, University of Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa. Electronic address:
The mycobacterial mutasome - comprising ImuA', ImuB, and DnaE2 - has been implicated in DNA damage-induced mutagenesis in Mycobacterium tuberculosis. ImuB, which is predicted to enable mutasome function via its interaction with the β clamp, is a catalytically inactive Y-family DNA polymerase. Like some other members of the Y-family, ImuB features a recently identified amino acid motif with homology to the RecA N-terminus (RecA-NT).
View Article and Find Full Text PDFKidney360
December 2024
Department of Physics, P.O. Box 64, FI-00014 University of Helsinki, Finland.
Background: Structural analysis of soft biological tissues is conventionally done with destructive 2D histology. 3D information can be accessed with non-invasive imaging methods, such as X-ray micro-computed tomography (micro-CT). While attenuation-based X-ray imaging alone does not provide reasonable contrast with soft-tissue samples, the combination with contrast-enhancing staining has proven effective.
View Article and Find Full Text PDFClin Hemorheol Microcirc
December 2024
Institute of Biotechnology, Molecular Cell Biology, Brandenburg University of Technology Cott-bus-Senftenberg, Senftenberg, Germany.
Background And Objective: Modern ultrasound technology enables detailed tissue morphology analysis. A novel approach involves measuring viscoelasticity or viscosity. This pilot study investigates the potential of a novel high-end ultrasound system with dynamic quality indicators and the M-Ref tool.
View Article and Find Full Text PDFJ Gen Physiol
January 2025
Department of Pharmacology, University of Virginia, School of Medicine, Charlottesville, VA, USA.
Pannexin 1 (PANX1) is a member of a topologically related and stoichiometrically diverse family of large pore membrane ion channels that support the flux of signaling metabolites (e.g., ATP) and fluorescent dyes.
View Article and Find Full Text PDFDalton Trans
December 2024
Department of Biotechnology, Institute of Biotechnology, College of Natural Sciences, University of Rzeszow, Pigonia 1, Rzeszow PL35-310, Poland.
In this work, we are showing the results of the X- and Q-band electron magnetic resonance measurements of ultra-small ZnMnFeO nanoparticles ( 8 nm) with a very narrow size distribution. The chosen synthetic route allows for precise structural modifications with a broad concentration range ( = 0, 0.2, 0.
View Article and Find Full Text PDFNucleic Acids Res
December 2024
International Institute of Molecular and Cell Biology in Warsaw, Ksiecia Trojdena 4, 02-109 Warsaw, Poland.
In vitro transcription (IVT) is a technology of vital importance that facilitated the production of mRNA therapeutics and drove numerous breakthroughs in RNA biology. T7 polymerase-produced RNAs can begin with either 5'-triphosphate guanosine (5'-pppG) or 5'-triphosphate adenosine (5'-pppA), generating potential agonists for the RIG-I/type I interferon response. While it is established that IVT can yield highly immunogenic double-stranded RNA (dsRNA) via promoterless transcription, the specific contribution of initiating nucleosides to this process has not been previously reported.
View Article and Find Full Text PDFJ Nematol
March 2024
Department of Zoology and Entomology, University of the Free State, PO Box 339, Bloemfontein 9300, South Africa.
Molecular data should be combined with morphological data to enhance the reliability of phylogenetic and diagnostic studies on nematodes. In this study, the citrus nematode collected from citrus orchards in different localities in Fars province, southern Iran, was characterized using the partial sequencing of ITS rDNA, D2-D3 of 28S rDNA and COI mtDNA genes. We also morphometrically characterized the second-stage juveniles (J2) and male specimens.
View Article and Find Full Text PDFFront Bioeng Biotechnol
December 2024
Boehringer Ingelheim, Viral Therapeutics Center, Ochsenhausen, Germany.
Viral products keep gaining importance in multiple therapeutic fields. Considering the scale and production slot limitations, optimizing the outcome of every manufacturing batch is essential to minimize costs and make this therapeutic modality broadly available to patients. Most manufacturing processes for oncolytic viruses currently in clinical studies are based on a batch process.
View Article and Find Full Text PDFBioinform Biol Insights
December 2024
Laboratory of Microbial Genomics and Metabolic Engineering, Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chattogram, Bangladesh.
COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) had an adverse effect globally because it caused a global pandemic with several million deaths. This virus possesses spike protein that is cleaved or activated by Furin-like protease enzymes occurring by mammalian lung or respiratory cells to enter the mammalian body. The addition of the Furin cleavage site in SARS-CoV-2 makes it a more infectious and emerging virus than its ancestor's viruses.
View Article and Find Full Text PDFFood Chem
December 2024
Grain Science and Industry, Kansas State University, Manhattan, Kansas 66506, USA. Electronic address:
Grain-based gluten-free cookies are often nutritionally inferior owing to their low protein content. This study aimed to enhance the nutritional value of gluten-free cookies by incorporating soy flour and to investigate the effects of different types of modified soy flour on the properties of gluten-free dough and cookies. Results indicate that all types of modified soy flour significantly decreased water absorption capacity (p < 0.
View Article and Find Full Text PDFMed Oncol
December 2024
Department of Medical Biology, Faculty of Medicine, Ordu University, Ordu, Turkey.
Thyroid cancer continues to be a notable health issue, requiring the creation of novel treatment methods to enhance patient results. The objective of this study is to investigate the potential of utilizing bee venom (BV)-loaded zeolitic imidazolate framework-8 (ZIF-8) nanoparticles as a novel strategy for specifically targeting and treating medullary thyroid cancer cells. Due to their wide surface area and configurable pore size, ZIF-8 nanoparticles are ideal for drug delivery.
View Article and Find Full Text PDFMicrobiol Resour Announc
December 2024
Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.
A lytic bacteriophage, BAU.Micro_SLP-22, was isolated from drain water in search of bio-controlling agents against avian salmonellosis. The phage genome is comprised of 59,738 bp with 56.
View Article and Find Full Text PDFMater Today Bio
December 2024
Immunology & Immuno-bioengineering, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, NG7 2RD, United Kingdom.
Dendritic cells (DCs) have emerged as a promising target for drug delivery and immune modulation due to their pivotal role in initiating the adaptive immune response. Gold nanoparticles (AuNPs) have garnered interest as a platform for targeted drug delivery due to their biocompatibility, low toxicity and precise control over size, morphology and surface functionalization. Our investigation aimed to elucidate the intracellular uptake and trafficking of AuNPs coated with different combinations of monosaccharides (mannose, galactose, and fucose) in DCs.
View Article and Find Full Text PDFInt J Ophthalmol
December 2024
Molecular Biology and Genetics Department, Liaquat University of Medical and Health Sciences, Jamshoro 76090, Pakistan.
Aim: To find out the association of secreted protein acidic and rich in cysteine (SPARC)-related modular calcium binding 2 () gene variants rs2255680 and rs13208776 with genotypic and phenotypic characteristics in both familial and non-familial primary open angle glaucoma (POAG) patients.
Methods: A total of 212 POAG patients, comprising 124 familial and 88 non-familial, were enrolled. For genotyping the variant rs2255680, amplification refractory mutation system (ARMS)-polymerase chain reaction (PCR) method and PCR-restriction fragment length polymorphism (PCR-RFLP) were utilized for analyzing rs13208776 variant.
RSC Med Chem
December 2024
College of Pharmacy, Gachon University Hambakmoeiro 191, Yeonsu-gu Incheon 21924 Republic of Korea +82 32 820 4948 +82 32 820 4945.
Aquaporins (AQPs) are integral membrane proteins responsible for facilitating the transmembrane transport of water and small solutes. Their involvement in diverse physiological functions extends to pathological conditions, including cancer, positioning them as promising targets for anticancer therapy. Tumor cells, particularly those with high metastatic potential, exhibit elevated AQP expression, reinforcing their critical role in tumor biology.
View Article and Find Full Text PDFPNAS Nexus
December 2024
Amity Institute of Biotechnology, Amity University Haryana, Gurgaon, Haryana 122413, India.
In , RecA plays a central role in the rescue of stalled replication forks, double-strand break (DSB) repair, homologous recombination (HR), and induction of the SOS response. While the RecA-dependent pathway is dominant, alternative HR pathways that function independently of RecA do exist, but relatively little is known about the underlying mechanism. Several studies have documented that a variety of proteins act as either positive or negative regulators of RecA to ensure high-fidelity HR and genomic stability.
View Article and Find Full Text PDFBMC Biol
December 2024
Minerva Foundation Institute for Medical Research, Tukholmankatu 8, 00290, Helsinki, Finland.
Background: Many members of the oxysterol-binding protein-related protein (ORP) family have been characterized in detail over the past decades, but the lipid transport and other functions of ORP7 still remain elusive. What is known about ORP7 points toward an endoplasmic reticulum and plasma membrane-localized protein, which also interacts with GABA type A receptor-associated protein like 2 (GABARAPL2) and unlipidated Microtubule-associated proteins 1A/1B light chain 3B (LC3B), suggesting a further autophagosomal/lysosomal association. Functional roles of ORP7 have been suggested in cholesterol efflux, hypercholesterolemia, and macroautophagy.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
December 2024
Department of Biotechnology, Institute of Biotechnology, University of Rzeszow, Pigonia St. 1, 35-310, Rzeszów, Poland.
Although yerba mate has been known and used for hundreds of years, not all of its properties have been fully understood yet. Yerba mate is a source of many desirable substances, but it may also contain toxic metals and other substances that are harmful to health. Fifteen samples of yerba mate tea from three South American countries were analyzed.
View Article and Find Full Text PDFCurr Pharm Des
December 2024
Department of Life Science, Parul Institute of Applied Science, Parul University, Vadodara, Gujarat, India.
Cordyceps spp. (CS), a well-known medicinal mushroom that belongs to Tibetan medicine and is predominantly found in the high altitudes in the Himalayas. CS is a rich reservoir of various bioactive substances including nucleosides, sterols flavonoids, peptides, and phenolic compounds.
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