Effect of hydroxyapatite as a component of biostable composites on population and proliferation of mesenchymal stem cells.

Three groups of biostable composite materials were studied. The initial binder polymers (polymethylmethacrylate, polyamide-12, superhigh-molecular-weight polyethylene) and hydroxyapatite-containing composites on the basis of these polymers were tested. Biostable polymers, including those containing hydroxyapatite, were nontoxic for fibroblasts and mesenchymal stem cells: the adhesion parameters for these cells were maximum for polyamide-12 and superhigh-molecular-weight polyethylene and did not depend on the presence of hydroxyapatite.