Ablation of integrin-mediated cell-collagen communication alleviates fibrosis.

Objectives: Activation of fibroblasts is a hallmark of fibrotic processes. Besides cytokines and growth factors, fibroblasts are regulated by the extracellular matrix environment through receptors such as integrins, which transduce biochemical and mechanical signals enabling cells to mount appropriate responses according to biological demands. The aim of this work was to investigate the in vivo role of collagen-fibroblast interactions for regulating fibroblast functions and fibrosis.

The mechanical loading of the spine in physical activities.

Purpose: To summarize the mechanical loading of the spine in different activities of daily living and sports.

Methods: Since the direct measurement is not feasible in sports activities, a mathematical model was applied to quantify spinal loading of more than 600 physical tasks in more than 200 athletes from several sports disciplines. The outcome is compression and torque (normalized to body weight/mass) at L4/L5.

Effects of body orientation and direction of movement on a knee joint angle reproduction test in healthy subjects: An experimental study.

Background: Joint position sense test assess patient mobility and proprioceptive ability. Yet, application used under different conditions may biases reproduction error resulting in different therapeutic consequences.

Objective: To investigate knee angle reproduction test under different test conditions.

Speed and surface steepness affect internal tibial loading during running.

Background: Internal tibial loading is influenced by modifiable factors with implications for the risk of stress injury. Runners encounter varied surface steepness (gradients) when running outdoors and may adapt their speed according to the gradient. This study aimed to quantify tibial bending moments and stress at the anterior and posterior peripheries when running at different speeds on surfaces of different gradients.

A Multidimensional Assessment of a Novel Adaptive Versus Traditional Passive Ankle Sprain Protection Systems.

Background: Ankle braces aim to reduce lateral ankle sprains. Next to protection, factors influencing user compliance, such as sports performance, motion restriction, and users' perceptions, are relevant for user compliance and thus injury prevention. Novel adaptive protection systems claim to change their mechanical behavior based on the intensity of motion (eg, the inversion velocity), unlike traditional passive concepts of ankle bracing.

Validity and Test-Retest Reliability of the Vmaxpro Sensor for Evaluation of Movement Velocity in the Deep Squat.

Feuerbacher, JF, Jacobs, MW, Dragutinovic, B, Goldmann, J-P, Cheng, S, and Schumann, M. Validity and test-retest reliability of the Vmaxpro sensor for evaluation of movement velocity in the deep squat. J Strength Cond Res 37(1): 35-40, 2023-We aimed at assessing the validity and test-retest reliability of the inertial measurement unit-based Vmaxpro sensor compared with a Vicon 3D motion capture system and the T-Force sensor during an incremental 1-repetition maximum (1RM) test and at submaximal loads.

Unanticipated fake-and-cut maneuvers do not increase knee abduction moments in sport-specific tasks: Implication for ACL injury prevention and risk screening.

Non-contact anterior cruciate ligament injuries typically occur during cutting maneuvers and are associated with high peak knee abduction moments (KAM) within early stance. To screen athletes for injury risk or quantify the efficacy of prevention programs, it may be necessary to design tasks that mimic game situations. Thus, this study compared KAMs and ranking consistency of female handball players in three sport-specific fake-and-cut tasks of increasing complexity.

Movement in low gravity environments (MoLo) programme-The MoLo-L.O.O.P. study protocol.

Background: Exposure to prolonged periods in microgravity is associated with deconditioning of the musculoskeletal system due to chronic changes in mechanical stimulation. Given astronauts will operate on the Lunar surface for extended periods of time, it is critical to quantify both external (e.g.

EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis.

EMILIN1 (elastin-microfibril-interface-located-protein-1) is a structural component of the elastic fiber network and localizes to the interface between the fibrillin microfibril scaffold and the elastin core. How EMILIN1 contributes to connective tissue integrity is not fully understood. Here, we report bi-allelic EMILIN1 loss-of-function variants causative for an entity combining cutis laxa, arterial tortuosity, aneurysm formation, and bone fragility, resembling autosomal-recessive cutis laxa type 1B, due to EFEMP2 (FBLN4) deficiency.

Futsal playing surface characteristics significantly affect perceived traction and change of direction performance among experienced futsal players.

We aimed to clarify the effect of different futsal playing surface structural properties on the resultant change of direction (COD) performance, perceived traction and frictional properties. Twenty experienced male university soccer players performed a COD slalom-course test and perceived traction evaluation on three different types of playing surfaces (area-elastic: AE, point-elastic no.1: PE1 and point-elastic no.

Athletes with high knee abduction moments show increased vertical center of mass excursions and knee valgus angles across sport-specific fake-and-cut tasks of different complexities.

Young female handball players represent a high-risk population for anterior cruciate ligament (ACL) injuries. While the external knee abduction moment (KAM) is known to be a risk factor, it is unclear how cutting technique affects KAMs in sport-specific cutting maneuvers. Further, the effect of added game specificity (e.

Physical Activity During Lockdowns Associated with the COVID-19 Pandemic: A Systematic Review and Multilevel Meta-analysis of 173 Studies with 320,636 Participants.

Background: Many countries have restricted public life in order to contain the spread of the novel coronavirus (SARS-CoV2). As a side effect of related measures, physical activity (PA) levels may have decreased.

Objective: We aimed (1) to quantify changes in PA and (2) to identify variables potentially predicting PA reductions.

Dynamic pressure analysis of novel interpositional knee spacer implants in 3D-printed human knee models.

Alternative treatment methods for knee osteoarthritis (OA) are in demand, to delay the young (< 50 Years) patient's need for osteotomy or knee replacement. Novel interpositional knee spacers shape based on statistical shape model (SSM) approach and made of polyurethane (PU) were developed to present a minimally invasive method to treat medial OA in the knee. The implant should be supposed to reduce peak strains and pain, restore the stability of the knee, correct the malalignment of a varus knee and improve joint function and gait.

Synthesising 2D Video from 3D Motion Data for Machine Learning Applications.

To increase the utility of legacy, gold-standard, three-dimensional (3D) motion capture datasets for computer vision-based machine learning applications, this study proposed and validated a method to synthesise two-dimensional (2D) video image frames from historic 3D motion data. We applied the video-based human pose estimation model OpenPose to real (in situ) and synthesised 2D videos and compared anatomical landmark keypoint outputs, with trivial observed differences (2.11−3.

The effect of vibration on kinematics and muscle activation during cycling.

Vibration has the potential to compromise performance in cycling. This study aimed to investigate the effects of vibration on full-body kinematics and muscle activation time series. Nineteen male amateur cyclists (mass 74.

Cervical spine and muscle adaptation after spaceflight and relationship to herniation risk: protocol from 'Cervical in Space' trial.

Background: Astronauts have a higher risk of cervical intervertebral disc herniation. Several mechanisms have been attributed as causative factors for this increased risk. However, most of the previous studies have examined potential causal factors for lumbar intervertebral disc herniation only.

Reliability of Running Economy Measurements: Influence of Shoe Familiarisation.

The purpose was to investigate differences in reliability of running economy measurements between familiar and unfamiliar shoes. Thirty-seven runners were included who all ran in familiar and unfamiliar running shoes while running economy was measured at steady state using a treadmill. Each participant was tested on two different visits (three sessions in total), with two trials in each of the three shoe conditions completed at each visit.

A novel guideline for the analysis of linear acceleration mechanics - outlining a conceptual framework of 'shin roll' motion.

Linear acceleration is a key performance determinant and major training component of many sports. Although extensive research about lower limb kinetics and kinematics is available, consistent definitions of distinctive key body positions, the underlying mechanisms and their related movement strategies are lacking. The aim of this 'Method and Theoretical Perspective' article is to introduce a conceptual framework which classifies the sagittal plane 'shin roll' motion during accelerated sprinting.

Ablation of the miRNA cluster 24 in cartilage and osteoblasts impairs bone remodeling.

MicroRNAs (miRNAs) post-transcriptionally regulate cartilage and bone development and function, however, only few miRNAs have been described to play a role for cartilage to bone transition in vivo. Previously, we showed that cartilage-specific deletion of the Mirc24 cluster in newborn male mice leads to impaired growth plate cartilage development due to increased RAF/MEK/ERK signaling and affects the stability of the cartilage extracellular matrix on account of decreased SOX6 and SOX9 and increased MMP13 levels. Here, we studied how Mirc24 cluster inactivation in cartilage and osteoblasts leads to an increased bone density associated with defects in collagen remodeling in trabecular bone.

The effect of footwear outsole material on slip resistance on dry and contaminated surfaces with geometrically controlled outsoles.

Previous studies have compared slip resistance of commercially available footwear, however, often lacking the ability to isolate factors such as material and surface properties, or/and geometry. The aim of this study was to compare slip resistance of geometrically identical shoes with varying outsole materials. Three left Ecco Xpedition III shoes were constructed out of three different outsole materials: polyurethane (PU), thermoplastic polyurethane (TPU) and vulcanised rubber (RU).

Carbon Plate Shoes Improve Metabolic Power and Performance in Recreational Runners.

This study compared metabolic power (MP) and time trial (TT) running performance between Adidas Adizero Adios (AAA) and Nike VaporFly 4% (NVP). Thirty-seven runners completed three laboratory sessions and two field sessions (n=30). After familiarization (visit 1), participants completed eight 6-min treadmill running bouts (four with each shoe, counterbalanced) at their preferred pace, and MP was assessed using indirect calorimetry (visits 2 and 3).

Relationship between different serum cartilage biomarkers in the acute response to running and jumping in healthy male individuals.

The effect of physical activity on serum cartilage biomarkers is largely unknown. The purpose of the study was to systematically analyze the acute effect of two frequently used exercise interventions (running and jumping) on the correlation of seven serum biomarkers that reflect cartilage extracellular matrix metabolism. Fifteen healthy male volunteers (26 ± 4 years, 181 ± 4 cm, 77 ± 6 kg) participated in the repeated measurement study.

Bisphenol A-Related Effects on Bone Morphology and Biomechanical Properties in an Animal Model.

Bisphenol A (BPA), which is contained in numerous plastic products, is known to act as an endocrine-disruptive, toxic, and carcinogenic chemical. This experimental series sought to determine the influence of BPA exposure on the femoral bone architecture and biomechanical properties of male and female Wistar rats. BPA was applied subcutaneously by using osmotic pumps.