2 results match your criteria: "Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction[Affiliation]"
Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.
J Biol Chem
February 2011
Institute of Biochemistry and Molecular Biology I-Cellular Signal Transduction, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Recent studies have shown that inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) possesses important roles in the development of immune cells. IP3KB can be targeted to multiple cellular compartments, among them nuclear localization and binding in close proximity to the plasma membrane. The B isoform is the only IP3K that is almost ubiquitously expressed in mammalian cells.
View Article and Find Full Text PDFNAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist.
Proc Natl Acad Sci U S A
June 2009
The Calcium Signaling Group, University Medical Centre Hamburg-Eppendorf, Centre of Experimental Medicine, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction, 20246 Hamburg, Germany.
Article Synopsis
- NAADP is identified as a second messenger that plays a role in calcium (Ca(2+)) signaling in lymphoma T cells, but its effects on primary T cells remain unclear.
- A synthetic inhibitor called BZ194 was developed to specifically block NAADP's action without affecting other calcium mobilization pathways or capacitative calcium entry.
- BZ194 effectively reduced Ca(2+) mobilization and its downstream effects, such as T cell activation and proliferation, suggesting its potential use in autoimmune disease therapies by modulating T-cell responses.