Coaxial Direct Ink Writing of Cholesteric Liquid Crystal Elastomers in 3D Architectures.

Cholesteric liquid crystal elastomers (CLCEs) hold great promise for mechanochromic applications in anti-counterfeiting, smart textiles, and soft robotics, thanks to the structural color and elasticity. While CLCEs are printed via direct ink writing (DIW) to fabricate free-standing films, complex 3D structures are not fabricated due to the opposing rheological properties necessary for cholesteric alignment and multilayer stacking. Here, 3D CLCE structures are realized by utilizing coaxial DIW to print a CLC ink within a silicone ink.

The long reach of adversity: Intermediary pathways from maternal adverse childhood experiences to child socio-emotional and cognitive outcomes.

Background: This longitudinal study with multi-informant (maternal, paternal, and experimenter) and multimethod (questionnaires, behavioral observations, and standardized assessments) data tests an intergenerational model from mothers' adverse childhood experiences (ACEs) to their children's socio-emotional and cognitive outcomes.

Methods: Participants were 501 children (50.7% male) and caregivers (56.

Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes.

Prions are assemblies of misfolded prion protein that cause several fatal and transmissible neurodegenerative diseases, with the most common phenotype in humans being sporadic Creutzfeldt-Jakob disease (sCJD). Aside from variation of the prion protein itself, molecular risk factors are not well understood. Prion and prion-like mechanisms are thought to underpin common neurodegenerative disorders meaning that the elucidation of mechanisms could have broad relevance.

A OHCs-Targeted Strategy for PEDF Delivery in Noise-Induced Hearing Loss.

Noise-induced hearing loss (NIHL) results from prolonged exposure to intense noise, causing damage to sensory outer hair cells (OHCs) and spiral ganglion neurons (SGNs). The blood labyrinth barrier (BLB) hinders systemic drug delivery to the inner ear. This study applied a retro-auricular round window membrane (RWM) method to bypass the BLB, enabling the transport of macromolecular proteins into the inner ear.

Single Rare-Earth Ion Doped Tin-Oxo Nanocluster Photoresists for High-Resolution Extreme Ultraviolet Lithography.

Rare-earth (RE) metals are known as industrial vitamins and show significant regulatory effects in many fields. In this work, we first demonstrated that the vitamin effect of RE metals can also be applied to extreme ultraviolet (EUV) lithography. Using a SnRE oxo cluster as the universal platform, different individual RE metal ions were successfully doped to obtain a series of isomorphic heterometallic clusters (RE = Y, Sm, Eu, Ho, Er).

Bipartite interference and air pollution transport: estimating health effects of power plant interventions.

Evaluating air quality interventions is confronted with the challenge of interference since interventions at a particular pollution source likely impact air quality and health at distant locations, and air quality and health at any given location are likely impacted by interventions at many sources. The structure of interference in this context is dictated by complex atmospheric processes governing how pollution emitted from a particular source is transformed and transported across space and can be cast with a bipartite structure reflecting the two distinct types of units: (i) interventional units on which treatments are applied or withheld to change pollution emissions; and (ii) outcome units on which outcomes of primary interest are measured. We propose new estimands for bipartite causal inference with interference that construe two components of treatment: a "key-associated" (or "individual") treatment and an "upwind" (or "neighborhood") treatment.

Effect of one-week New Zealand blackcurrant extract on rowing performance and cognitive function in National team male rowers.

This research investigated the impact of New Zealand blackcurrant (NZBC) on 2000-meter rowing ergometer performance and cognitive abilities. Nine trained male rowers from Iran's national team participated in a double-blind, placebo-controlled crossover study, undergoing three sessions with NZBC (600 mg∙day-1), placebo (PL), and control (CL) treatments over seven days, followed by a 14-day washout period. Participants completed a 2000-meter ergometer test provided self-reported ratings of perceived exertion (RPE) and completed a cognitive function assessment five minutes following the rowing exercise.

Anthropometry, body composition, somatotype and asymmetry of canoe sprint world champion: A case study.

Body composition is a determinant of physical fitness and sports performance. To describe the anthropometric characteristics, body composition, somatotype, and asymmetries of the 2023 world champion in the C1-1000 canoeing event. Dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and anthropometry were used to describe the athlete's body composition.

Medical Students' Acceptance of Tailored e-Mental Health Apps to Foster Their Mental Health: Cross-Sectional Study.

Background: Despite the high prevalence of mental health problems among medical students and physicians, help-seeking remains low. Digital mental health approaches offer beneficial opportunities to increase well-being, for example, via mobile apps.

Objective: This study aimed to assess the acceptance, and its underlying predictors, of tailored e-mental health apps among medical students by focusing on stress management and the promotion of personal skills.

Exploring Chemical Profiles, Antifeedant, Nematicidal and Phytotoxic Potentials of Seven Essential Oils from Eucalyptus Species.

Leaf essential oils (EOs) of seven Eucalyptus species from southern Tunisia (E. gracilis, E. lesouefii, E.

Deployment and transcriptional evaluation of nitisinone, an FDA-approved drug, to control bed bugs.

Background: Bed bugs are blood-feeders that rapidly proliferate into large indoor infestations. Their bites can cause allergies, secondary infections and psychological stress, among other problems. Although several tactics for their management have been used, bed bugs continue to spread worldwide wherever humans reside.

Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization.

Background: Achieving a stable vasculature is crucial for tissue regeneration. Endothelial cells initiate vascular morphogenesis, followed by mural cells that stabilize new vessels. This study investigated the in vivo effects of Sema4D-Plexin-B1 signaling on stem cells from human exfoliated deciduous teeth (SHED)-supported angiogenesis, focusing on its mechanism in PDGF-BB secretion.

Impact of geographical variation on nutritional and antioxidant properties of Basella alba L. from Sri Lanka.

Background: Basella alba L. (Malabar spinach) is a widely consumed leafy vegetable, well known for its nutritional and therapeutic properties. These properties arise from the availability of essential nutrients, phytochemicals, and antioxidant potential, which may vary depending on environmental factors induced by the geographical location.

Diagnostic and therapeutic strategies in combating implanted medical device-associated bacterial biofilm infections.

Bacterial biofilms exhibit remarkable resistance against conventional antibiotics and are capable of evading the humoral immune response. They account for nearly 80% of chronic infections in humans. Development of bacterial biofilms on medical implants results in their malfunctioning and subsequently leads to high mortality rates worldwide.

Statistical identification of cell type-specific spatially variable genes in spatial transcriptomics.

An essential task in spatial transcriptomics is identifying spatially variable genes (SVGs). Here, we present Celina, a statistical method for systematically detecting cell type-specific SVGs (ct-SVGs)-a subset of SVGs exhibiting distinct spatial expression patterns within specific cell types. Celina utilizes a spatially varying coefficient model to accurately capture each gene's spatial expression pattern in relation to the distribution of cell types across tissue locations, ensuring effective type I error control and high power.

Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation.

Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor whose dysfunction is linked to developmental dysplasia of the hip, osteoporosis and osteoarthritis. Our work addresses the critical question of how these skeletal pathologies emerge. Here, we show the abundant expression of LRP1 in skeletal progenitor cells at mouse embryonic stage E10.

Long-term reconstructed vegetation index dataset in China from fused MODIS and Landsat data.

The vegetation index is a key satellite-based variable used to monitor global vegetation distribution and growth. However, existing vegetation index datasets face limitations in achieving both high spatial and temporal resolution, restricting their application potential. This study revised a machine learning spatiotemporal fusion model (InENVI) to produce a high-resolution NDVI dataset with 8-day temporal and 30 m spatial resolution, covering China from 2001 to 2020.

The quality of orientation for newly hired nurses in acute care settings in a university hospital: A cross-sectional study.

Aims: This study aims to describe how newly hired nurses assess the quality of the orientation in acute care settings in a university hospital.

Background: Orientation for newly hired nurses in acute care settings, where special competence, ability to collaborate with different professional groups, and wide technical and technological skills are required, is crucial to ensure patient safety and high-quality standards in nursing care.

Methods: A cross-sectional study design was applied.

[Residential areas, travel burdens, and children with cancer: Analysis of mobility and mortality ratios using data from Japan's national population-based cancer registry].

Objectives　Although childhood cancer treatment has recently become centralized at specialized hospitals worldwide, the relationship between mortality ratios and living in rural areas or traveling long distances for treatment remains controversial. In the present study, we examined whether regional differences in patient mobility and mortality ratios exist in Japan.Methods　We investigated 10,713 patients with cancer aged ≤18 years, diagnosed between 2016 and 2019, registered in the national cancer registry data.

Poor agreement among asthma specialists on the choice and timing of initiation of a biologic treatment for severe asthma patients.

Background: As the number of monoclonal antibodies available for severe asthma is growing, specialists currently choose without clear guidelines. Despite increasing knowledge on treatment response to these monoclonal antibodies, making the optimal choice for each individual patient remains a challenge. However, evidence of this daily challenge is lacking.

Describing the landscape of nutrition- and diet-related randomized controlled trials: meta-research study of protocols published between 2012 and 2022.

Background: Publishing protocols promotes transparency and reproducibility. The scope and methods of protocols for nutrition- and diet-related randomized controlled trials (RCTs) have not been investigated yet.

Objective: Map the landscape of nutrition- and diet-related interventions research.

Topographical Mapping of Metabolic Abnormalities in Multiple Sclerosis using Rapid Echo-less 3D-MR Spectroscopic Imaging at 7T.

Objectives: To assess topographical patterns of metabolic abnormalities in the cerebrum of multiple sclerosis (MS) patients and their relationship to clinical disability using rapid echo-less 3D-MR spectroscopic imaging (MRSI) at 7T.

Materials And Methods: This study included 26 MS patients (13 women; median age 34) and 13 age- and sex-matched healthy controls (7 women; median age 33). Metabolic maps were obtained using echo-less 3D-MRSI at 7T with a 64 × 64 × 33 matrix and a nominal voxel size of 3.

Using Laboratory Test Results for Surveillance During a New Outbreak of Acute Hepatitis in 3-Week- to 5-Year-Old Children in the United Kingdom, the Netherlands, Ireland, and Curaçao: Observational Cohort Study.

Background: In March 2022, a concerning rise in cases of unexplained pediatric hepatitis was reported in multiple countries. Cases were defined as acute hepatitis with serum transaminases >500 U/L (aspartate transaminase [AST] or alanine transaminase [ALT]) in children aged 16 years or younger. We explored a simple federated data analytics method to search for evidence of unreported cases using routinely held data.

Behaviour of 7.62x39mm tracer and API bullets in soft tissue.

Some bullets, called tracer and API bullets, contain a pyrotechnical charge. The charge in the bottom of a tracer bullet burns in flight and enables the shooter or an observer to see the bullet's trajectory. An Armor Piercing Incendiary (API) bullet contains a hard core and a pyrotechnical charge that ignites on impact with a hard target.