8 results match your criteria: "Institute of Advanced Studies in Basic Sciences[Affiliation]"
Mol Divers
August 2024
Laboratory of Bioinformatics and Drug Design, University of Tehran, Tehran, Iran.
Efficient drug discovery relies on drug repurposing, an important and open research field. This work presents a novel factorization method and a practical comparison of different approaches for drug repurposing. First, we propose a novel tensor-matrix-tensor (TMT) formulation as a new data array method with a gradient-based factorization procedure.
View Article and Find Full Text PDFBMC Bioinformatics
February 2023
Laboratory of Bioinformatics and Drug Design, University of Tehran, Tehran, Iran.
Background: Due to the high resource consumption of introducing a new drug, drug repurposing plays an essential role in drug discovery. To do this, researchers examine the current drug-target interaction (DTI) to predict new interactions for the approved drugs. Matrix factorization methods have much attention and utilization in DTIs.
View Article and Find Full Text PDFMikrochim Acta
July 2021
Department of Chemistry, Institute of Advanced Studies in Basic Sciences, Zanjan, Iran.
Molecularly imprinted polymers are efficient and selective adsorbents which act as artificial receptors for desired compounds with the ability to recognize the size, shape, and functional groups of the compounds simultaneously. A molecularly imprinted polymer is prepared by the polymerization of functional monomers around a template (analyte) molecule. Afterward, the removal of the template from the polymer matrix leaves a selective cavity behind.
View Article and Find Full Text PDFFront Neural Circuits
December 2021
Department of Physics, Institute of Advanced Studies in Basic Sciences, Zanjan, Iran.
The brain functional network extracted from the BOLD signals reveals the correlated activity of the different brain regions, which is hypothesized to underlie the integration of the information across functionally specialized areas. Functional networks are not static and change over time and in different brain states, enabling the nervous system to engage and disengage different local areas in specific tasks on demand. Due to the low temporal resolution, however, BOLD signals do not allow the exploration of spectral properties of the brain dynamics over different frequency bands which are known to be important in cognitive processes.
View Article and Find Full Text PDFSci Rep
June 2020
Physics Department, Institute of Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran.
In this paper, we introduce a non-invasive optical method, named Paraxial Self-Reference Interferometry (PSRI) for thickness measurement of liquid films. The method can be used for thin or thick layers (from μm to mm) of solids or liquids, with a high precision. The method is first applied to solid plates with known thickness and is verified to be accurate.
View Article and Find Full Text PDFSci Rep
February 2020
University of Waterloo, Cheriton School of Computer Science, Waterloo, N2L3G1, Canada.
The collective behaviour of neural networks depends on the cellular and synaptic properties of the neurons. The phase-response curve (PRC) is an experimentally obtainable measure of cellular properties that quantifies the shift in the next spike time of a neuron as a function of the phase at which stimulus is delivered to that neuron. The neuronal PRCs can be classified as having either purely positive values (type I) or distinct positive and negative regions (type II).
View Article and Find Full Text PDFLuminescence
May 2020
Department of Chemistry, Institute of Advanced Studies in Basic Sciences, Zanjan, Iran.
In this study, dilution analysis and anion exchange chromatography (AEC) were employed to provide insights into the photoluminescence (PL) of carbon nanodots (CNDs). A stepwise dilution process revealed that some of the fluorophores with higher energy emission were quenched in the high concentration solution and appeared in the dilute solutions. AEC fractionation led to seven sorts of CND fractions with similar surface charges.
View Article and Find Full Text PDFBiochem Biophys Res Commun
September 2018
A.N. Belozersky Institute of Physical-Chemical Biology, Moscow State University, Leninskie Gory 1-40, Moscow, 119992, Russia. Electronic address:
An electrometrical technique was used to investigate electron transfer between synthetic binuclear manganese (Mn) complexes, designated M - 2 and M - 3, and the redox-active neutral tyrosine radical (Y) in proteoliposomes containing Mn-depleted photosystem II (PS II) core particles in response to single laser flashes. In the absence of Mn-containing compounds, the observed flash-induced membrane potential (ΔΨ) decay was mainly due to charge recombination between the reduced primary quinone acceptor Q and the oxidized Y. More significant slowing down of the ΔΨ decay in the presence of lower concentrations of M - 2 and M - 3 associated with electron donation from Mn in the Mn-binding site to Y indicates that these synthetic compounds are more effective electron donors than MnCl.
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