2 results match your criteria: "Institute for Pigmentary Disorders in Association with Ernst-Moritz-Arndt University[Affiliation]"

Disease-related behavioral patterns and experiences affect quality of life in children and adolescents with vitiligo.

Int J Dermatol

January 2014

Institute for Pigmentary Disorders in association with Ernst Moritz Arndt University, Greifswald, GermanyCentre for Skin Sciences, School of Life Sciences, University of Bradford, Bradford, UK.

Background: Vitiligo is an acquired, non-contagious depigmentation disorder involving a patchy loss of skin color. It often leads to stigmatization, embarrassment, and reduced quality of life (QoL) in adult patients. Little is known about children's reactions.

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Patients with vitiligo accumulate millimolar levels of H(2)O(2) in their epidermis. The recycling process of (6R)-l-erythro-5,6,7,8-tetrahydrobiopterin in these patients is disrupted due to deactivation of 4a-OH-BH(4) dehydratase by H(2)O(2). The H(2)O(2) oxidation products 6- and 7-biopterin lead to the characteristic fluorescence of the affected skin upon Wood's light examination (UVA 351 nm).

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