Systematic reviews do not adequately report or address missing outcome data in their analyses: a methodological survey.

Objectives: To describe how systematic review authors report and address categories of participants with potential missing outcome data of trial participants.

Study Design And Setting: Methodological survey of systematic reviews reporting a group-level meta-analysis.

Results: We included a random sample of 50 Cochrane and 50 non-Cochrane systematic reviews.

Airway management in the presence of cervical spine instability: A cross-sectional survey of the members of the Indian Society of Neuroanaesthesiology and Critical Care.

Background And Aims: There is a paucity of clinical practice guidelines for the ideal approach to airway management in patients with cervical spine instability (CSI). The aim of this survey was to evaluate preferences, perceptions and practices regarding airway management in patients with CSI among neuroanaesthesiologists practicing in India.

Methods: A 25-item questionnaire was circulated for cross-sectional survey to 378 members of the Indian Society of Neuroanaesthesiology and Critical Care (ISNACC) by E-mail.

Mechanism-specific rehabilitation management of complex regional pain syndrome: Proposed recommendations from evidence synthesis.

Study Design: Narrative review.

Introduction: There are a variety of treatments with demonstrated effectiveness for the management of complex regional pain syndrome (CRPS). However given the variability in symptom presentation in this population, therapists may be unsure what treatments would be most effective for individual clients.

Rat model of cancer-induced bone pain: changes in nonnociceptive sensory neurons in vivo.

Introduction: Clinical data on cancer-induced bone pain (CIBP) suggest extensive changes in sensory function. In a previous investigation of an animal model of CIBP, we have observed that changes in intrinsic membrane properties and excitability of dorsal root ganglion (DRG) nociceptive neurons correspond to mechanical allodynia and hyperalgesia.

Objectives: To investigate the mechanisms underlying changes in nonnociceptive sensory neurons in this model, we have compared the electrophysiological properties of primary nonnociceptive sensory neurons at <1 and >2 weeks after CIBP model induction with properties in sham control animals.

Low-intensity pulsed ultrasound for treatment of tibial fractures: an economic evaluation of the TRUST study.

Aims: This 501-patient, multi-centre, randomised controlled trial sought to establish the effect of low-intensity, pulsed, ultrasound (LIPUS) on tibial shaft fractures managed with intramedullary nailing. We conducted an economic evaluation as part of this trial.

Patients And Methods: Data for patients' use of post-operative healthcare resources and time taken to return to work were collected and costed using publicly available sources.

Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.

Background And Objective: Breast cancer surgery is associated with acute and chronic pain. We sought to systematically evaluate the effects of gabapentin and pregabalin on postoperative pain among patients undergoing breast cancer surgery.

Databases And Data Treatment: We searched MEDLINE, EMBASE, CENTRAL, Web of Science, and ProQuest from the inception of each database to November 2015.

Reliability and validity of clinical tests to assess the anatomical integrity of the cervical spine in adults with neck pain and its associated disorders: Part 1-A systematic review from the Cervical Assessment and Diagnosis Research Evaluation (CADRE) Collaboration.

Objective: To determine the reliability and validity of clinical tests to assess the anatomical integrity of the cervical spine in adults with neck pain and its associated disorders.

Methods: We updated the systematic review of the 2000-2010 Bone and Joint Decade Task Force on Neck Pain and its Associated Disorders. We also searched the literature to identify studies on the reliability and validity of Doppler velocimetry for the evaluation of cervical arteries.

Incretin based treatments and mortality in patients with type 2 diabetes: systematic review and meta-analysis.

 To assess the impact of incretin based treatment on all cause mortality in patients with type 2 diabetes. Systematic review and meta-analysis of randomised trials. Medline, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.

Premature Discontinuation of Pediatric Randomized Controlled Trials: A Retrospective Cohort Study.

Objectives: To determine the proportion of pediatric randomized controlled trials (RCTs) that are prematurely discontinued, examine the reasons for discontinuation, and compare the risk for recruitment failure in pediatric and adult RCTs.

Study Design: A retrospective cohort study of RCTs approved by 1 of 6 Research Ethics Committees (RECs) in Switzerland, Germany, and Canada between 2000 and 2003. We recorded trial characteristics, trial discontinuation, and reasons for discontinuation from protocols, corresponding publications, REC files, and a survey of trialists.

Factors associated with the duration of disability benefits claims among Canadian workers: a retrospective cohort study.

Background: Disability insurance protects workers from total loss of income in case of a disabling injury or illness by providing wage-replacement benefits. To better inform early identification of claims at risk of prolonged recovery, we explored predictors of the duration of disability benefits claims.

Methods: We conducted a retrospective cohort study using claims data provided by SSQ Life Insurance Company Inc.

Low intensity pulsed ultrasound for bone healing: systematic review of randomized controlled trials.

 To determine the efficacy of low intensity pulsed ultrasound (LIPUS) for healing of fracture or osteotomy. Systematic review and meta-analysis. Medline, Embase, CINAHL, Cochrane Central Register of Controlled Trials, and trial registries up to November 2016.

Somatosensory rehabilitation for allodynia in complex regional pain syndrome of the upper limb: A retrospective cohort study.

Study Design: Retrospective cohort study.

Introduction: Somatosensory rehabilitation is a standardized method of evaluation and conservative treatment of painful disorders of vibrotactile sensation, including the mechanical allodynia and burning pain of complex regional pain syndrome (CRPS).

Purpose Of The Study: The purpose of this study was to examine the effectiveness of somatosensory rehabilitation for reducing allodynia in persons with CRPS of 1 upper limb in a retrospective consecutive cohort of patients.

Effects of different phosphate lowering strategies in patients with CKD on laboratory outcomes: A systematic review and NMA.

Background: Chronic kidney disease-mineral and bone disorder (CKD-MBD), a complication of chronic kidney disease, has been linked to reduced quality and length of life. High serum phosphate levels that result from CKD-MBD require phosphate-lowering agents, also known as phosphate binders. The objective of this systematic review is to compare the effects of available phosphate binders on laboratory outcomes in patients with CKD-MBD.

Patients' Attitudes Toward Nonphysician Screening of Low Back and Low Back Related Leg Pain Complaints Referred for Surgical Assessment.

Study Design: A questionnaire survey.

Objective: The aim of this study was to explore patient attitudes toward screening to assess suitability for low back surgery by nonphysician health care providers.

Summary Of Background Data: Canadian spine surgeons have shown support for nonphysician screening to assess and triage patients with low back pain and low back related leg pain.

Inter-rater agreement in evaluation of disability: systematic review of reproducibility studies.

Objectives:  To explore agreement among healthcare professionals assessing eligibility for work disability benefits.

Design:  Systematic review and narrative synthesis of reproducibility studies.

Data Sources:  Medline, Embase, and PsycINFO searched up to 16 March 2016, without language restrictions, and review of bibliographies of included studies.

Behavioural Effects of Using Sulfasalazine to Inhibit Glutamate Released by Cancer Cells: A Novel target for Cancer-Induced Depression.

Despite the lack of robust evidence of effectiveness, current treatment options for cancer-induced depression (CID) are limited to those developed for non-cancer related depression. Here, anhedonia-like and coping behaviours were assessed in female BALB/c mice inoculated with 4T1 mammary carcinoma cells. The behavioural effects of orally administered sulfasalazine (SSZ), a system x inhibitor, were compared with fluoxetine (FLX).

Attitudes toward the Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain: A qualitative study.

Background: Chronic noncancer pain (CNCP) refers to all pain disorders, not due to cancer, that persist for ≥3 months. The point prevalence of CNCP in the general population of Western countries is between 19 and 33 percent. Opioids are commonly prescribed for CNCP and are associated with both benefits and harms.

Predictors of in-hospital mortality among patients with pulmonary tuberculosis: a protocol of systematic review and meta-analysis of observational studies.

Introduction: Tuberculosis (TB) continues to be a major public health issue worldwide, with 1.4 million deaths occurring annually. There is uncertainty regarding which factors are associated with in-hospital mortality among patients with pulmonary TB.