Lemur Tyrosine Kinase 2 (LMTK2) Level Inversely Correlates with Phospho-Tau in Neuropathological Stages of Alzheimer's Disease.

Alzheimer's disease (AD) is the most common neurodegenerative dementia. Mapping the pathomechanism and providing novel therapeutic options have paramount significance. Recent studies have proposed the role of LMTK2 in AD.

Production cross sections of radioisotopes from He-particle induced nuclear reactions on natural titanium.

Excitation functions were measured using the stacked-foil method for the Ti(He,x)Sc, Sc, Sc, Sc, V and Cr nuclear processes up to 68MeV. Our new cross-section data were compared with the earlier reported values as well as the evaluated theoretical predictions by means of the TALYS 1.6 code as compiled in the TENDL-2015 library.

Evaluation of nuclear reaction cross sections for optimization of production of the emerging diagnostic radionuclide ⁵⁵Co.

The excitation functions of the (54)Fe(d,n)(55)Co, (56)Fe(p,2n)(55)Co and (58)Ni(p,α)(55)Co reactions were analyzed with relevance to the production of the β(+)-emitter (55)Co (T½=17.53 h), a promising cobalt radionuclide for PET imaging. The nuclear model codes ALICE-IPPE, EMPIRE and TALYS were used to check the consistency of the experimental data.

Activation cross-sections of proton induced reactions on natural Ni up to 65MeV.

Production cross-sections of the (nat)Ni(p,x)(60,61)Cu, (56,57)Ni, (55,56,57,58)Co nuclear reactions were measured in five experiments up to 65MeV by using a stacked foil activation technique. The results were compared with the available literature values, predictions of the nuclear reaction model codes ALICE-IPPE, TALYS-1.4, and extracted data from the TENDL-2012 library.

Cross sections of deuteron induced reactions on (nat)Sm for production of the therapeutic radionuclide ¹⁴⁵Sm and ¹⁵³Sm.

At present, targeted radiotherapy (TR) is acknowledged to have great potential in oncology. A large list of interesting radionuclides is identified, including several radioisotopes of lanthanides, amongst them (145)Sm and (153)Sm. In this work the possibility of their production at a cyclotron was investigated using a deuteron beam and a samarium target.

Activation cross-sections of deuteron induced reaction of natural Ni up to 40 MeV.

Production cross-sections of (nat)Ni(d,x)(56,57)Ni, (55,56,57,58)Co, (52,54)Mn, and (51)Cr nuclear reactions were measured up to 40 MeV by using the stacked foil technique. The results were compared with the literature values, TALYS 1.4 and TENDL-2012.

Investigation of activation cross-section data of proton induced nuclear reactions on rhenium.

In the frame of systematic investigations of activation cross-section data for different applications the excitation functions of (nat)Re(p,x)(185)Os, (183m)Os, (183g)Os, (182)Os, (181m)Os, (186g)Re, (184m)Re, (184g)Re, (183)Re, (182m)Re, (182g)Re and (181g)Re reactions were measured up to 70MeV. The data for the (nat)Re(p,x) (183m)Os, (183g)Os, (182)Os, (181g)Os,(186g)Re, (184m)Re,(182m)Re, (182g)Re, and (181)Re reactions are reported for the first time. The activation method, the stacked foil irradiation technique and γ-spectroscopy for activity detection were used.