Double Porphyrin Cage Compounds.

The synthesis and characterization of double porphyrin cage compounds are described. They consist of two porphyrins that are each attached to a diphenylglycoluril-based clip molecule via four ethyleneoxy spacers, and are linked together by a single alkyl chain using "click"-chemistry. Following a newly developed multistep synthesis procedure we report three of these double porphyrin cages, linked by spacers of different lengths, i.

Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized Acetylneuraminate Lyase in a Continuous Flow Reactor.

The synthesis of -acetylneuraminic acid (Neu5Ac) derivatives is drawing more and more attention in glycobiology research because of the important role of sialic acids in e. g. cancer, bacterial, and healthy cells.

Effect of Chirality on the Binding of Viologen Guests in Porphyrin Macrocycles.

As part of a project aimed at the development of chiral processive catalysts that can write information on a polymer chain we describe the synthesis of two optically active porphyrin macrocycles, which are prepared in 3 steps from an achiral precursor compound. Fluorescence and H-NMR studies show that one of the macrocycles displays selectivity in the binding of chiral viologen guest molecules.

Recent Advances in Engineering the Stem Cell Microniche in 3D.

Conventional 2D cell culture techniques have provided fundamental insights into key biochemical and biophysical mechanisms responsible for various cellular behaviors, such as cell adhesion, spreading, division, proliferation, and differentiation. However, 2D culture in vitro does not fully capture the physical and chemical properties of the native microenvironment. There is a growing body of research that suggests that cells cultured on 2D substrates differ greatly from those grown in vivo.

Nature of the Ru-NO Coordination Bond: Kohn-Sham Molecular Orbital and Energy Decomposition Analysis.

We have analyzed structure, stability, and Ru-NO bonding of the -[RuCl(NO)(NH)] complex by using relativistic density functional theory. First, we focus on the bond dissociation energies associated with the three canonical dissociation modes leading to [RuCl(NH)]+NO, [RuCl(NH)]+NO, and [RuCl(NH)]+NO. The main objective is to understand the Ru-NO bonding mechanism in the conceptual framework of Kohn-Sham molecular orbital theory in combination with a quantitative energy decomposition analysis.