3 results match your criteria: "Institute for Molecular and Personalized Medicine[Affiliation]"
The ANKK1/DRD2 gene TaqIA polymorphism (rs1800497) is associated with the severity of extrapyramidal side effects of haloperidol treatment in CYP2D6 extensive metabolizers with schizophrenia spectrum disorders.
Drug Metab Pers Ther
June 2023
Molecular Genetics Laboratory, Serbsky National Medical Research Center on Psychiatry and Addictions, Moscow, Russian Federation.
Objectives: Extrapyramidal symptoms (EPS) are one of the most prominent side effects of haloperidol. Variability of EPS severity may be associated with the genetic factors, affecting both haloperidol pharmacokinetics (e.g.
View Article and Find Full Text PDFAssessment of Diagnostic Specificity of Anti-SARS-CoV-2 Antibody Tests and Their Application for Monitoring of Seroconversion and Stability of Antiviral Antibody Response in Healthcare Workers in Moscow.
Microorganisms
February 2022
Clinic & Research Institute for Molecular and Personalized Medicine, Russian Medical Academy of Continuous Professional Education, 125993 Moscow, Russia.
Anti-SARS-CoV-2 antibody testing is an efficient tool to assess the proportion of seropositive population due to infection and/or vaccination. Numerous test systems utilizing various antigen composition(s) are routinely used for detection and quantitation of anti-SARS-CoV-2 antibodies. We determined their diagnostic specificity using archived true-negative samples collected before the onset of the COVID-19 pandemic.
View Article and Find Full Text PDFMicroRNAs as Novel Biomarkers for P2Y12 - Inhibitors Resistance Prediction.
Pharmgenomics Pers Med
December 2021
Institute for Molecular and Personalized Medicine, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation.
Article Synopsis
- The study aims to evaluate six micro-RNAs as potential biomarkers for predicting resistance to P2Y12-inhibitors in patients with acute coronary syndrome.
- Eighty patients treated with either ticagrelor or clopidogrel underwent genotyping to assess specific polymorphisms and measured expression levels of the six miRNAs, with results correlating to platelet reactivity.
- The findings suggest that miR-29, miR-34, miR-126, miR-142, and miR-223 could serve as valuable biomarkers for identifying P2Y12-inhibitor resistance, potentially replacing traditional platelet reactivity tests.