Antioxidants (Basel)
December 2024
Department of Immunology, Jeonbuk National University Medical School, Jeonju 54907, Republic of Korea.
Psoriasis is a chronic inflammatory skin disorder characterized by abnormal immune responses and keratinocyte hyperproliferation. Limonin, a bioactive compound found in citrus fruits, has anti-inflammatory properties in various models; however, its effects on psoriasis are not fully understood. We investigated the therapeutic potential of limonin in a 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced psoriasis mouse model.
View Article and Find Full Text PDFActa Radiol
January 2025
R Madhavan Nayar Center for Comprehensive Epilepsy Care, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
Background: The role of imaging in autoimmune encephalitis (AIE) remains unclear, and there are limited data on the utility of magnetic resonance imaging (MRI) to diagnose, treat, or prognosticate AIE.
Purpose: To evaluate whether MRI is a diagnostic and prognostic marker for AIE and assess its efficacy in distinguishing between various AIE subtypes.
Material And Methods: We analyzed data from 96 AIE patients from our prospective autoimmune registry.
J Korean Med Sci
January 2025
Department of Preventive Medicine, Jeonbuk National University Medical School, Jeonju, Korea.
Background: The Field Epidemiology Training Program Frontline, initiated by the Korea Disease Control and Prevention Agency in 2019, aims to enhance the competencies of infectious disease practitioners across 17 regions in South Korea. With the September 2024 amendment to the Infectious Disease Prevention Act mandating infectious disease prevention and crisis response training for government employees who are associated with infectious diseases responses, there is an urgent need to assess and optimize the effectiveness and cost-efficiency of such competency-based education programs amidst constraints of budget and manpower.
Methods: This study examined the educational needs and priorities of public health competencies among infectious disease practitioners.
BMC Cardiovasc Disord
January 2025
Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Background: The dried root of Inula helenium L., known as Inulae Radix in Mongolian medicine, is a widely used heat-clearing plant drug within the Asteraceae family. Alantolactone (ATL), a compound derived from Inulae Radix, is a sesquiterpene lactone with a range of biological activities.
View Article and Find Full Text PDFWorld J Pediatr Congenit Heart Surg
January 2025
Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences - Guwahati, Guwahati, India.
Nat Commun
January 2025
Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum, India.
Survival outcomes of patients with heart failure (HF) based on their disease etiology are not well described. Here, we provide one-year mortality outcomes of 10850 patients with HF (mean age = 59.9 years, 31% women) in India.
View Article and Find Full Text PDFFront Public Health
January 2025
Indian Institute of Public Health Delhi, New Delhi, India.
The COVID-19 pandemic has significantly challenged healthcare systems worldwide, particularly in India, a country already burdened with a high prevalence of Neglected Tropical Diseases (NTDs). This perspective examines the pandemic's direct and indirect impacts on the prevalence, diagnosis, and management of NTDs in India. Using a narrative review approach, we analyzed literature published between January 2020 and September 2023 from databases such as PubMed, Scopus, and Google Scholar, along with grey literature.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Laboratory for Structural Bioinformatics, Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan. Electronic address:
The formation of the pyroglutamate variant of amyloid beta (pGlu-Aβ), which is extremely hydrophobic, rapidly aggregating, and highly neurotoxic, is mediated by the action of secretory glutaminyl cyclase (sQC). The pGlu-Aβ often acts as a seed for the aggregation of the full length Aβ and contributes to the overall load of Aβ plaques in Alzheimer's disease (AD). Therefore, inhibiting sQC is a potential approach to limit the formation of pGlu-Aβ and to modify the progression of AD.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
March 2025
Division of Molecular Medicine, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695012, India. Electronic address:
In this work, the interaction behaviour of gold nanoparticles (AuNPs) with o-phenylenediamine (OPD) was studied to ascertain the nanozyme-substrate interaction. The UV-Vis absorption, high-resolution transmission electron microscopy and zeta potential analysis revealed that the electron-rich nitrogen atoms in OPD showed a stronger affinity toward electron-deficient surface, indicating a stronger interaction between nanozyme and substrate molecules. Subsequently, under optimum conditions, AuNPs are used as nanozyme to catalyze the oxidation of OPD in the presence of HO.
View Article and Find Full Text PDFJ Artif Organs
December 2024
Division of Thrombosis Research, Department of Applied Biology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojappura, Thiruvananthapuram, 695012, Kerala, India.
Three-dimensional bioprinting is getting enormous attention among the scientific community for its application in complex regenerative tissue engineering applications. One of the focus areas of 3-D bioprinting is Skin tissue engineering. Skin is the largest external organ and also the outer protective layer is prone to injuries due to accidents, burns, pathologic diseases like diabetes, and immobilization of patients due to other health conditions, etc.
View Article and Find Full Text PDFComput Biol Med
February 2025
Department of Applied Mechanics and Biomedical Engineering, Indian Institute of Technology Madras, Chennai, 600036, Tamil Nadu, India. Electronic address:
Background And Objective: Cerebral aneurysms occur as balloon-like outpouchings in an artery, which commonly develop at the weak curved regions and bifurcations. When aneurysms are detected, understanding the risk of rupture is of immense clinical value for better patient management. Towards this, Fluid-Structure Interaction (FSI) studies can improve our understanding of the mechanics behind aneurysm initiation, progression, and rupture.
View Article and Find Full Text PDFJ Family Med Prim Care
November 2024
Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute For Medical Sciences and Technology, Trivandrum, Kerala, India.
Introduction: Blood groups documented in motor vehicle driving licenses can provide quick information during emergency transfusion requirements and imbibe self-awareness about one's blood group. The tendency of applicants to mention blood groups without verification during the application may result in incorrect documentation of blood groups in their driving license. The study aims to assess the reliability of the blood groups in driving licenses and their association with sociodemographic variables.
View Article and Find Full Text PDFJ Family Med Prim Care
November 2024
Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Background: Sociodemographic factors can significantly influence the knowledge level of tuberculosis (TB) patients, affecting the overall health outcomes. Due to lack of awareness and the stigma associated with TB, Indian TB elimination efforts are facing challenges. Patients with less information are more likely to experience delays in diagnosis and proper care.
View Article and Find Full Text PDFFront Physiol
December 2024
Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, Liaoning, China.
Acta Biochim Biophys Sin (Shanghai)
December 2024
Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.
( . ) has long been a part of the human diet and medicine. Although .
View Article and Find Full Text PDFInt J Stroke
January 2025
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.
Background: Stroke is a leading cause of global mortality and disability, with a disproportionately high burden in low- and middle-income countries. Access to intravenous thrombolysis (IVT) and endovascular treatment (EVT) remains extremely limited.
Aims: We evaluated the spatial distribution and geographic accessibility of stroke centers in India.
Risk Manag Healthc Policy
December 2024
Department of International Affairs and Social Sciences, College of Humanities and Social Sciences, Zayed University, Abu Dhabi, United Arab Emirates.
The Israel military occupation, ongoing for over 75 years, has profoundly impacted the health and well-being of Palestinians. Despite longstanding calls for Universal Health Coverage (UHC) and sustainable development, the response of global health systems and organizations to crises such as the recent large-scale military assault on Gaza in October 2023 has been inadequate. There is a critical need to examine why these global health approaches have failed and how they can be restructured to address the unique challenges in Gaza effectively.
View Article and Find Full Text PDFJ Pediatr Hematol Oncol
January 2025
Department of Pediatric Oncology, Regional Cancer Centre.
Background: Pediatric germ cell tumor (GCT) with extensive cavo-atrial tumor thrombus presenting as an oncologic emergency is extremely rare.
Observation: A 13-month-old female child with sacrococcygeal GCT having inferior vena cava (IVC) and right atrial thrombus presenting with anasarca and respiratory distress is reported. Because of worsening symptoms post initiation of chemotherapy, tumor thrombus debulking from the right atrium and distal end of IVC was performed on day 9 on an emergency basis.
J Biosci
December 2024
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695012, India.
In response to unfavourable conditions and environmental duress, follows an alternative developmental stage called the dauer larva, which is associated with various metabolic changes. Dauers can survive in harsh conditions for several months. They resume their development on returning to favourable conditions.
View Article and Find Full Text PDFJ Ovarian Res
December 2024
Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, 116044, China.
Ann Pediatr Cardiol
November 2024
Department of CVTS, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
Association of Ebstein's anomaly of tricuspid valve (TV) with tetralogy of Fallot (TOF) is extremely rare. Their coexistence is unique as they modify each other's physiology. We report a case of a girl child having this rare combination along with Diamond-Blackfan syndrome awaiting a bone marrow transplant.
View Article and Find Full Text PDFAnn Pediatr Cardiol
November 2024
Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
A 10-year-old girl underwent successful device closure of a 15-mm atrial septal defect with a short and thick retroaortic rim using a 16-mm atrial septal occluder from the conventional approach under transesophageal echocardiographic guidance. There were no periprocedural complications. The aortic valve was noted to be trileaflet and competent.
View Article and Find Full Text PDFInt J Pharm X
December 2024
Laboratory of Microfluidics and Medical Microsystems, Research Institute for Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Indian J Radiol Imaging
January 2025
Department of Cardiovascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
Takayasu arteritis (TA) is a form of large vessel vasculitis that may lead to fibrosis, stenosis, or aneurysm formation of vessels. Its presentation varies depending on the arterial beds involved. We report 3 cases out of around 150 cases of TA with rare initial presentations of brachial plexopathy caused by an axillary artery aneurysm, complicated type A intramural hematoma, and renal artery aneurysms along with abdominothoracic TA presenting as a pulsatile abdominal mass.
View Article and Find Full Text PDFNeurol India
November 2024
Kerala Registry of Epilepsy and Pregnancy Study Group, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
Background: Cerebral vascular malformations are rare but important causes of epilepsy in young women. The risk of bleed during pregnancy and delivery as well as the fetal outcomes are important concerns for women with epilepsy (WWE) due to cerebral vascular malformations (EVM).
Objectives: We compared the maternal and fetal outcomes of a cohort of EVM with women with focal epilepsy due to other causes (ENVM).
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