Blue-enriched office light competes with natural light as a zeitgeber.

Objectives: Circadian regulation of human physiology and behavior (eg, body temperature or sleep-timing), depends on the "zeitgeber" light that synchronizes them to the 24-hour day. This study investigated the effect of changing light temperature at the workplace from 4000 Kelvin (K) to 8000 K on sleep-wake and activity-rest behavior.

Methods: An experimental group (N=27) that experienced the light change was compared with a non-intervention group (N=27) that remained in the 4000 K environment throughout the 5-week study period (14 January to 17 February).

A salutogenic analysis of developmental tasks and ego integrity vs. despair.

This study examines the hypothesis that the outcome of the Eriksonian crisis of integrity vs. despair is dependent on successful coping with four developmental tasks: maintenance of active involvement, reevaluation of life satisfaction, developing a sense of health maintenance, and reevaluation of the sense of coherence (SOC). A selective sample of 170 rather healthy individuals at the mean age of 67 years filled out a questionnaire assessing everyday activities, satisfaction with past, present, and future life, healthy habits, SOC, and depression.

Sequelae of prospective versus retrospective reports of adverse childhood experiences.

Retrospective assessment of adverse childhood experiences is widely used in research, although there are concerns about its validity. In particular, recall bias is assumed to produce significant artifacts. Data from a longitudinal cohort (the British National Child Development Study; N=7710) and the retrospective Mainz Adverse Childhood Experiences Study (N=1062, Germany) were compared on 10 adverse childhood experiences and psychological adjustment at age 42 yr.

Perceived barriers to prostate cancer screenings among middle-aged men in north-eastern Germany.

Objectives: Prostate cancer ranks high in mortality. Only 18% of men entitled for screenings take advantage of this. Social-cognitive models of health psychology describe and predict health behavior.

Modeling a circadian surface.

Experiments that systematically varied T, τ, and photoperiod in Neurospora crassa revealed that the traditional nonparametric and parametric approaches could not explain entrainment for all of the tested conditions. The authors have developed a new approach to understanding entrainment that incorporates several features of the old paradigms but allows exploration of the underlying mechanisms in synchronized clocks, making extrapolations from constant conditions to entrained state unnecessary. It is based on a circadian integrated response characteristic (CIRC) that makes no assumptions about how entrainment occurs (by phase shifts or velocity changes).

Entrainment concepts revisited.

The traditional approaches to predict entrainment of circadian clocks by light are based on 2 concepts that were never successfully unified: the non-parametric approach assumes that entrainment occurs via discrete daily phase shifts while the parametric approach assumes that entrainment involves changes of the clock's velocity. Here the authors suggest a new approach to predict and model entrainment. Unlike the traditional approaches, it does not assume a priori the mechanism of how the internal and external cycle lengths are matched (via phase shifts, velocity changes, or even other mechanisms).

A circadian surface of entrainment: varying T, τ, and photoperiod in Neurospora crassa.

The two major prerequisites for a functional circadian system are the generation of an internal day (circadian cycle) and adjusting its length-and phase-to that of the external day (zeitgeber cycle). The generation of circadian cycles can be observed in constant conditions where organisms show a self-sustained, free-running rhythm. Their expression depends on the nature of the constant conditions (e.

Entrainment elicits period aftereffects in Neurospora crassa.

Circadian clocks continue to oscillate in constant conditions with their own period (tau) and entrain to a cyclic environment by adjusting their intrinsic period to that of the zeitgeber. When circadian clocks are released from entrained to constant conditions, the tau of their initial free-run often depends on the nature of the prior zeitgeber. These postentrainment effects on period (tau-aftereffects) have predominantly been reported for animals but, so far, not fungi.

A spatial paradigm, the allothetic place avoidance alternation task, for testing visuospatial working memory and skill learning in rats.

We present a paradigm for assessing visuospatial working memory and skill learning in a rodent model, based on the place avoidance test. In our allothetic place avoidance alternation task (APAAT) the paradigm is comprised of minimal training sessions, tests various aspects of learning and memory and provides a rich set of parameters. A single working memory session consists of four conditions: habituation (no shock), two place avoidance training intervals (shock activated) and a retrieval test (shock inactivated).

Cognitive abilities, behaviour and quality of life in children after liver transplantation.

Aims: We investigated interrelations between cognitive abilities, behavioural problems, quality of life and disease-related variables of children after LTX.

Methods: Our sample consisted of 25 children. They were 8.

Are fear-avoidance beliefs in low back pain patients a risk factor for low physical activity or vice versa? A cross-lagged panel analysis.

Objective: The assumption that low back pain (LBP) patients suffer from "disuse" as a consequence of high fear-avoidance beliefs is currently under debate. A secondary analysis served to investigate whether fear-avoidance beliefs are associated cross-sectionally and longitudinally with the physical activity level (PAL) in LBP patients.

Methods: A total of 787 individuals (57% acute and 43% chronic LBP) were followed up over a period of one year with measurements of fear-avoidance beliefs and physical activity level.

Is light-at-night a health risk factor or a health risk predictor?

In 2007, the IARC (WHO) has classified "shift-work that involves circadian disruption" as potentially carcinogenic. Ample evidence leaves no doubt that shift-work is detrimental for health, but the mechanisms behind this effect are not well understood. The hormone melatonin is often considered to be a causal link between night shift and tumor development.

Health-related quality of life of children and adolescents with growth hormone deficiency or idiopathic short stature - part 2: available results and future directions.

Research on the health-related quality of life (HrQoL) impact of short stature and its treatment in children and adolescents has developed recently. Based on a PubMed literature search, studies addressing this issue were identified and considerable methodological problems mainly related to the HrQoL instruments used and conflicting results are discussed in this mini review. Additionally, this mini review identifies a need for further research and indicates potential directions.

Assessment of health-related quality of life and patient satisfaction in children and adolescents with growth hormone deficiency or idiopathic short stature - part 1: a critical evaluation of available tools.

The concept of health-related quality of life (HrQoL) reflects the subjective perception of health and includes aspects of well-being and functioning in physical, emotional, mental and social life domains. Nowadays, HrQoL has become a relevant treatment outcome from epidemiological and clinical perspectives and is also broadly employed in health economic analyses. To assess HrQoL generic as well as condition-specific instruments are used.

Differential impact of posterior lesions in the left and right hemisphere on visual category learning and generalization to contrast reversal.

Hemispheric differences in the learning and generalization of pattern categories were explored in two experiments involving sixteen patients with unilateral posterior, cerebral lesions in the left (LH) or right (RH) hemisphere. In each experiment participants were first trained to criterion in a supervised learning paradigm to categorize a set of patterns that either consisted of simple geometric forms (Experiment 1) or unfamiliar grey-level images (Experiment 2). They were then tested for their ability to generalize acquired categorical knowledge to contrast-reversed versions of the learning patterns.

Spatial filtering of MEG signals for user-specified spherical regions.

We introduce a spatial filtering method in the spherical harmonics domain for constraining magnetoencephalographic (MEG) multichannel measurements to any user-specified spherical region of interest (ROI) inside the head. The method relies on a linear transformation of the signal space separation inner coefficients that represent the MEG signal generated by sources located inside the head. The spatial filtering is achieved effectively by constructing a spherical harmonics basis vector that is dependent on the center of the targeted ROI and it does not require any discrete division of the headspace into grids like the traditional MEG spatial filtering approaches.

Challenges of patient-reported outcome assessment in hemophilia care—a state of the art review.

Introduction: One of the recent advances in assessing outcomes of medical care is the inclusion of the patient perspective. The term patient-reported outcome (PRO) is used to reflect the patient perceptions of disease and its consequences as well as of treatment and health-care provision. The development of PRO measures has advanced rapidly, and implementation in clinical research and practice is now underway.

Pre-semantically defined temporal windows for cognitive processing.

Neuronal oscillations of different frequencies are hypothesized to be basic for temporal perception; this theoretical concept provides the frame to discuss two temporal mechanisms that are thought to be essential for cognitive processing. One such mechanism operates with periods of oscillations in the range of some tens of milliseconds, and is used for complexity reduction of temporally and spatially distributed neuronal activities. Experimental evidence comes from studies on temporal-order threshold, choice reaction time, single-cell activities, evoked responses in neuronal populations or latency distributions of oculomotor responses.

Smoking cessation counselling for pregnant and postpartum women among midwives, gynaecologists and paediatricians in Germany.

The incorporation of guidelines for the treatment of tobacco smoking into routine care requires positive attitudes, counselling skills and knowledge about additional help available for smokers. The study assesses performance of smoking cessation intervention, attitudes, training status and knowledge about additional help for smokers in the care for pregnant and parenting women by midwives, gynaecologists and paediatricians. A survey of all midwives, gynaecologists and paediatricians registered for primary medical care in the federal state Saarland, Germany, was conducted.

Cortisol levels predict motion sickness tolerance in women but not in men.

A variety of intrinsic and extrinsic factors contribute to motion sickness severity in a stressful motion environment. The interplay of all these factors may partially explain the high inter-subject variability of motion sickness susceptibility found in many studies as well as some of the contradictory findings between studies regarding the modulating influence of single factors. We investigated the role of endogenous cortisol levels, gender and repetitive experience for motion sickness susceptibility.

Subjective health in old age from a salutogenic perspective.

Objective: We applied Antonovsky's salutogenic model to healthy ageing. Basically, salutogenic theory states that generalized resistance resources build-up the sense of coherence which in turn determines an individual's health level. Specifically, we explored the status of the sense of coherence as a mediator variable.