Colon cancer diagnosis by means of explainable deep learning.

Early detection of the adenocarcinoma cancer in colon tissue by means of explainable deep learning, by classifying histological images and providing visual explainability on model prediction. Considering that in recent years, deep learning techniques have emerged as powerful techniques in medical image analysis, offering unprecedented accuracy and efficiency, in this paper we propose a method to automatically detect the presence of cancerous cells in colon tissue images. Various deep learning architectures are considered, with the aim of considering the best one in terms of quantitative and qualitative results.

DeClUt: Decluttering differentially expressed genes through clustering of their expression profiles.

Background And Objective: differential expression analysis is one of the most popular activities in transcriptomic studies based on next-generation sequencing technologies. In fact, differentially expressed genes (DEGs) between two conditions represent ideal prognostic and diagnostic candidate biomarkers for many pathologies. As a result, several algorithms, such as DESeq2 and edgeR, have been developed to identify DEGs.

Alzheimer's Disease Evaluation Through Visual Explainability by Means of Convolutional Neural Networks.

: Alzheimer's disease is nowadays the most common cause of dementia. It is a degenerative neurological pathology affecting the brain, progressively leading the patient to a state of total dependence, thus creating a very complex and difficult situation for the family that has to assist him/her. Early diagnosis is a primary objective and constitutes the hope of being able to intervene in the development phase of the disease.

Explainable Convolutional Neural Networks for Brain Cancer Detection and Localisation.

Brain cancer is widely recognised as one of the most aggressive types of tumors. In fact, approximately 70% of patients diagnosed with this malignant cancer do not survive. In this paper, we propose a method aimed to detect and localise brain cancer, starting from the analysis of magnetic resonance images.

Compensating for Sensing Failures via Delegation in Human-AI Hybrid Systems.

Given the increasing prevalence of intelligent systems capable of autonomous actions or augmenting human activities, it is important to consider scenarios in which the human, autonomous system, or both can exhibit failures as a result of one of several contributing factors (e.g., perception).

Transfer learning for the efficient detection of COVID-19 from smartphone audio data.

Disease detection from smartphone data represents an open research challenge in mobile health (m-health) systems. COVID-19 and its respiratory symptoms are an important case study in this area and their early detection is a potential real instrument to counteract the pandemic situation. The efficacy of this solution mainly depends on the performances of AI algorithms applied to the collected data and their possible implementation directly on the users' mobile devices.

Water Meter Reading for Smart Grid Monitoring.

Many tasks that require a large workforce are automated. In many areas of the world, the consumption of utilities, such as electricity, gas and water, is monitored by meters that need to be read by humans. The reading of such meters requires the presence of an employee or a representative of the utility provider.

Explainable AI for clinical and remote health applications: a survey on tabular and time series data.

Nowadays Artificial Intelligence (AI) has become a fundamental component of healthcare applications, both clinical and remote, but the best performing AI systems are often too complex to be self-explaining. Explainable AI (XAI) techniques are defined to unveil the reasoning behind the system's predictions and decisions, and they become even more critical when dealing with sensitive and personal health data. It is worth noting that XAI has not gathered the same attention across different research areas and data types, especially in healthcare.

Weighted simplicial complexes and their representation power of higher-order network data and topology.

Hypergraphs and simplical complexes both capture the higher-order interactions of complex systems, ranging from higher-order collaboration networks to brain networks. One open problem in the field is what should drive the choice of the adopted mathematical framework to describe higher-order networks starting from data of higher-order interactions. Unweighted simplicial complexes typically involve a loss of information of the data, though having the benefit to capture the higher-order topology of the data.

Machine Learning and Bioinformatics Framework Integration to Potential Familial DCM-Related Markers Discovery.

Objectives: Dilated cardiomyopathy (DCM) is characterized by a specific transcriptome. Since the DCM molecular network is largely unknown, the aim was to identify specific disease-related molecular targets combining an original machine learning (ML) approach with protein-protein interaction network.

Methods: The transcriptomic profiles of human myocardial tissues were investigated integrating an original computational approach, based on the Custom Decision Tree algorithm, in a differential expression bioinformatic framework.

AI applications in functional genomics.

We review the current applications of artificial intelligence (AI) in functional genomics. The recent explosion of AI follows the remarkable achievements made possible by "deep learning", along with a burst of "big data" that can meet its hunger. Biology is about to overthrow astronomy as the paradigmatic representative of big data producer.

Testing Off-the-Shelf Optical Wireless LANs for Smart City Environments.

Optical wireless LANs (OWLs) constitute an emerging networking paradigm for indoor scenarios' fit to different smart cities' fields of applications. Commercial products employing this technology have been made available on the market in recent years. In this work, we investigate, through a set of indoor communication experiments based on commercially available products, how different environmental and usage modes affect the performance of the system, addressing the presence of multiple users, the position and mobility of the mobile devices, the handover among adjacent cells and the effect of background lighting.

EZcount: An all-in-one software for microRNA expression quantification from NGS sequencing data.

MicroRNAs (miRNAs) are short endogenous molecules of RNA that influence cell regulation by suppressing genes. Their ubiquity throughout all branches of the tree of life has suggested their central role in many cellular functions. Nowadays, several personalized medicine applications rely on miRNAs as biomarkers for diagnoses, prognoses, and prediction of drug response.

Transfer learning for mobile real-time face mask detection and localization.

Objective: Due to the COVID-19 pandemic, our daily habits have suddenly changed. Gatherings are forbidden and, even when it is possible to leave the home for health or work reasons, it is necessary to wear a face mask to reduce the possibility of contagion. In this context, it is crucial to detect violations by people who do not wear a face mask.

Machine learning for coronavirus covid-19 detection from chest x-rays.

At the end of 2019, a new form of Coronavirus, called has widely spread in the world. To quickly screen patients with the aim to detect this new form of pulmonary disease, in this paper we propose a method aimed to automatically detect the disease by analysing medical images. We exploit supervised machine learning techniques building a model considering a data-set freely available for research purposes of 85 chest X-rays.

Radiomics for Gleason Score Detection through Deep Learning.

Prostate cancer is classified into different stages, each stage is related to a different Gleason score. The labeling of a diagnosed prostate cancer is a task usually performed by radiologists. In this paper we propose a deep architecture, based on several convolutional layers, aimed to automatically assign the Gleason score to Magnetic Resonance Imaging (MRI) under analysis.

Explainable Deep Learning for Pulmonary Disease and Coronavirus COVID-19 Detection from X-rays.

Background And Objective: Coronavirus disease (COVID-19) is an infectious disease caused by a new virus never identified before in humans. This virus causes respiratory disease (for instance, flu) with symptoms such as cough, fever and, in severe cases, pneumonia. The test to detect the presence of this virus in humans is performed on sputum or blood samples and the outcome is generally available within a few hours or, at most, days.

An ensemble learning approach for brain cancer detection exploiting radiomic features.

Background And Objective: The brain cancer is one of the most aggressive tumour: the 70% of the patients diagnosed with this malignant cancer will not survive. Early detection of brain tumours can be fundamental to increase survival rates. The brain cancers are classified into four different grades (i.

Formal methods for prostate cancer Gleason score and treatment prediction using radiomic biomarkers.

Prostate cancer is a significant public health burden and a major cause of morbidity and mortality among men worldwide. Only in 2018 were reported 1.3 million of new diagnosed patients.

Dot2dot: accurate whole-genome tandem repeats discovery.

Motivation: Large-scale sequencing projects have confirmed the hypothesis that eukaryotic DNA is rich in repetitions whose functional role needs to be elucidated. In particular, tandem repeats (TRs) (i.e.

Genome-wide analysis of NGS data to compile cancer-specific panels of miRNA biomarkers.

MicroRNAs are small non-coding RNAs that influence gene expression by binding to the 3' UTR of target mRNAs in order to repress protein synthesis. Soon after discovery, microRNA dysregulation has been associated to several pathologies. In particular, they have often been reported as differentially expressed in healthy and tumor samples.

A Smart Sensing Architecture for Domestic Monitoring: Methodological Approach and Experimental Validation.

Smart homes play a strategic role for improving life quality of people, enabling to monitor people at home with numerous intelligent devices. Sensors can be installed to provide a continuous assistance without limiting the resident's daily routine, giving her/him greater comfort, well-being and safety. This paper is based on the development of domestic technological solutions to improve the life quality of citizens and monitor the users and the domestic environment, based on features extracted from the collected data.