2 results match your criteria: "Institute for Drug Development at CTRC[Affiliation]"
Heat shock proteins: a potential anticancer target.
Curr Drug Targets
December 2011
Institute for Drug Development at CTRC, The University of Texas Health Science Center, San Antonio, TX, USA.
Heat shock proteins (Hsp) are highly conserved proteins and their expression is dependent on the level of various cellular stresses. Hsp work as a molecular chaperon for several cellular proteins and have cytoprotective roles. Their function is essential for normal cell viability and growth.
View Article and Find Full Text PDFPrevention of chemotherapy induced nausea and vomiting: a focus on aprepitant.
Expert Opin Drug Metab Toxicol
December 2009
The University of Texas Health Science Center, Institute for Drug Development at CTRC, Zeller's Building, San Antonio, TX, USA.
Background: Nausea and vomiting is one of the most feared side effects of chemotherapy; however, in the past 20 years, a better understanding of the pathophysiology of chemotherapy-induced nausea and vomiting (CINV) has led to the introduction of newer antiemetics, which have improved the management of this side effect.
Objective: This article reviews the prevention of CINV and the role of aprepitant, the first of the newest class of antiemetics, the neurokinin-1 inhibitors. A brief description of the pathophysiology of CINV and the background on the prevention of CINV using the 5-HT(3) antagonists is outlined.