Irisin: A Multifaceted Hormone Bridging Exercise and Disease Pathophysiology.

The fibronectin domain-containing protein 5 (FNDC5), or irisin, is an adipo-myokine hormone produced during exercise, which shows therapeutic potential for conditions like metabolic disorders, osteoporosis, sarcopenia, obesity, type 2 diabetes, and neurodegenerative diseases, including Alzheimer's disease (AD). This review explores its potential across various pathophysiological processes that are often considered independent. Elevated in healthy states but reduced in diseases, irisin improves muscle-adipose communication, insulin sensitivity, and metabolic balance by enhancing mitochondrial function and reducing oxidative stress.

Unveiling the self-assembly process of gellan-chitosan complexes through a combination of atomistic simulations and experiments.

Polyelectrolyte complexes (PECs), formed via the self-assembly of oppositely charged polysaccharides, are highly valued for their biocompatibility, biodegradability, and hydrophilicity, offering significant potential for biotechnological applications. However, the complex nature and lack of insight at a molecular level into polyelectrolytes conformation and aggregation often hinders the possibility of achieving an optimal control of PEC systems, limiting their practical applications. To address this problem, an in-depth investigation of PECs microscopic structural organization is required.

Face-to-face or face-to-screen: A quantitative comparison of conferences modalities.

The COVID-19 pandemic forced a societal shift from in-person to virtual activities, including scientific conferences. As society navigates a "new normal," the question arises as to the advantages and disadvantages of these alternative modalities. We introduce two new comprehensive datasets enabling direct comparison between virtual and in-person conferences: the first, from a series of nine small conferences, encompasses over 12,000 pairs of potential scientific collaborators across five virtual and four in-person meetings on a range of scientific topics; the expressed goal of these conferences is to create novel collaborations.

Assessing the interaction between the N-terminal region of the membrane protein magnesium transporter A and a lipid bilayer.

Unlabelled: This study investigates the interaction of KEIF, the intrinsically disordered N-terminal region of the magnesium transporter MgtA, with lipid bilayers mimicking cell membranes. Combining experimental techniques such as neutron reflectometry (NR), quartz-crystal microbalance with dissipation monitoring (QCM-D), synchrotron radiation circular dichroism (SRCD), and oriented circular dichroism (OCD), with molecular dynamics (MD) simulations, we characterized KEIF's adsorption behavior.

Hypothesis: KEIF undergoes conformational changes upon interacting with lipid bilayers, potentially influencing MgtA's function within the plasma membrane.

Controlling orbital ordering of intergrowth structures with flat [AgF] layers to mimic oxocuprates(II).

Based on density functional theory calculations, we propose a new pathway toward compounds featuring flat [AgF] layers which mimic [CuO] layers in high-temperature oxocuprate superconductor precursors. Calculations predict the dynamic (phonon) and energetic stability of the new phases over diverse substrates. For some compounds with ferro orbital ordering, we find a gigantic intrasheet superexchange constant of up to -211 meV (DFT+) and -256 meV (SCAN), calculated for hypothetical (CsMgF)KAgF intergrowth.

Functional ultrasound and brain connectivity reveal central nervous system compromise in Trembler-J mice model of Charcot-Marie-Tooth disease.

The Charcot-Marie-Tooth-1E (CMT1E) disease is typically described as a peripheral neuropathy in humans, causing decreased nerve conduction, spastic paralysis, and tremor. The Trembler-J (TrJ) mice serve as a high fidelity model of this disease. Here, we use functional ultrasound (fUS) and functional connectivity (FC) to analyze TrJ mice's brain activity during sensory stimulation and resting state experiments against wild type (WT) mice - the healthy counterpart.

Crowding effects on the structure and rheology of ultrasoft PNIPAM-PEGMA copolymer microgels.

We investigate the link between the internal microstructure of poly(-isopropylacrylamide)-poly(ethylene glycol) methyl ether methacrylate (PNIPAM-PEGMA) microgels, their bulk moduli and the rheological response and structural arrangement in dense suspensions. The low degree of crosslinking combined with the increased hydrophilicity induced by the presence of PEGMA results in a diffuse, star-like density profile of the particle and very low values of the bulk modulus in dilute conditions, as determined by small angle neutron scattering (SANS). The ultrasoft nature of the particle is reflected in the changes of the structural arrangement in dense suspensions, which evidence a strong deswelling and a sharp rise of the bulk modulus at moderate packing fractions.

Higher-order connectomics of human brain function reveals local topological signatures of task decoding, individual identification, and behavior.

Traditional models of human brain activity often represent it as a network of pairwise interactions between brain regions. Going beyond this limitation, recent approaches have been proposed to infer higher-order interactions from temporal brain signals involving three or more regions. However, to this day it remains unclear whether methods based on inferred higher-order interactions outperform traditional pairwise ones for the analysis of fMRI data.

Observation of Two-Dimensional Dam Break Flow and a Gaseous Phase of Solitons in a Photon Fluid.

We report the observation of a two-dimensional (2D) dam break flow of a photon fluid in a nonlinear optical crystal. By precisely shaping the amplitude and phase of the input wave, we investigate the transition from one-dimensional (1D) to 2D nonlinear dynamics. We observe wave breaking in both transverse spatial dimensions with characteristic timescales determined by the aspect ratio of the input box-shaped field.

Adapting to Individual Differences: An Experimental Study of Language Evolution in Heterogeneous Populations.

Variations in language abilities, use, and production style are ubiquitous within any given population. While research on language evolution has traditionally overlooked the potential importance of such individual differences, these can have an important impact on the trajectory of language evolution and ongoing change. To address this gap, we use a group communication game for studying this mechanism in the lab, in which micro-societies of interacting participants develop and use artificial languages to successfully communicate with each other.

Comprehensive characterization of waterlogged archaeological wood by NMR relaxometry, diffusometry, micro-imaging and cryoporometry.

Chemical, physical, and biological decay may partially or totally hide the historical and technological information carried by waterlogged wood. Investigation of the above-mentioned decay processes is essential to assess the wood preservation state, and it is important to find new methods for the consolidation and safeguarding of wooden archaeological heritage. A conventional method for assessing the wood preservation state is light microscopy.

Mathematical model for the distribution of DNA replication origins.

DNA replication in yeast and in many other organisms starts from well-defined locations on the DNA known as replication origins. The spatial distribution of these origins in the genome is particularly important in ensuring that replication is completed quickly. Cells are more vulnerable to DNA damage and other forms of stress while they are replicating their genome.

Delayed jamming-induced oscillatory migration patterns of epithelial collectives under long-range confinement.

Collective dynamics of cells in confined geometry regulate several biological processes including cell migration, proliferation, differentiation, and communication. In this work, combining simulation with experimental data, we studied the oscillatory motion of epithelial sheets in smaller areas of confinement, and we linked the monolayer maturation induced-jamming with the wave formation. We showed that epithelial cell populations with delayed jamming properties use the additional time available from this delay to coordinate their movement, generating wave motion in larger areas of confinement compared to control populations.

Analysis of Cytokine-Inducible SH2-Containing Protein (CISH) in the Study of Immunosenescence.

The aging immune system undergoes significant changes, leading to a state known as immunosenescence. Understanding the molecular mechanisms underlying immunosenescence is crucial for developing targeted interventions to enhance immune functions in older individuals. This bio-protocol review focuses on the application of quantitative reverse transcription-polymerase chain reaction (qRT-PCR) for the mRNA quantification of cytokine-inducible SH2-containing protein (CISH), an immune regulator overexpressed in T-cell responses from older adults.

Porcine Cross-Linked Collagen Matrix for Peri-Implant Vertical Soft Tissue Augmentation: A Randomized Prospective Observational Study.

The mucosa height has always been of interest in modern implant dentistry to obtain biomimetic results. Papilla height, mucosa scalloping, and free mucosal margin level are crucial to achieve "pink aesthetics". The aim of this study was to investigate the vertical increase in the peri-implant soft tissues with a porcine cross-linked collagen matrix (Geistlich Fibro-Gide).

Optimal Control of Underdamped Systems: An Analytic Approach.

Optimal control theory deals with finding protocols to steer a system between assigned initial and final states, such that a trajectory-dependent cost function is minimized. The application of optimal control to stochastic systems is an open and challenging research frontier, with a spectrum of applications ranging from stochastic thermodynamics to biophysics and data science. Among these, the design of nanoscale electronic components motivates the study of underdamped dynamics, leading to practical and conceptual difficulties.

Fibration symmetry-breaking supports functional transitions in a brain network engaged in language.

In his book 'A Beautiful Question', physicist Frank Wilczek argues that symmetry is 'nature's deep design,' governing the behavior of the universe, from the smallest particles to the largest structures. While symmetry is a cornerstone of physics, it has not yet been found widespread applicability to describe biological systems, particularly the human brain. In this context, we study the human brain network engaged in language and explore the relationship between the structural connectivity (connectome or structural network) and the emergent synchronization of the mesoscopic regions of interest (functional network).

Evaluating cervical spine mobility and Fitt's law compliance: The DidRen laser test adapted for virtual reality with age and sex effects.

Cervical spine mobility assessment is crucial in rehabilitation to monitor patient progress. This study introduces the DidRen VR test, a virtual reality (VR) adaptation of the conventional DidRen laser test, aimed at evaluating cervical spine mobility. We conducted a cross-sectional study involving fifty healthy participants that underwent the DidRen VR test.

Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations.

Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding brain health and disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex and neurodegeneration) on the brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American and Caribbean countries (LAC) and 8 non-LAC countries).

Unfolding the distribution of periodicity regions and diversity of chaotic attractors in the Chialvo neuron map.

We performed an exhaustive numerical analysis of the two-dimensional Chialvo map by obtaining the parameter planes based on the computation of periodicities and Lyapunov exponents. Our results allowed us to determine the different regions of dynamical behavior, identify regularities in the distribution of periodicities in regions indicating regular behavior, find some pseudofractal structures, identify regions such as the "eyes of chaos" similar to those obtained in parameter planes of continuous systems, and, finally, characterize the statistical properties of chaotic attractors leading to possible hyperchaotic behavior.

Global topological synchronization of weighted simplicial complexes.

Higher-order networks are able to capture the many-body interactions present in complex systems and to unveil fundamental phenomena revealing the rich interplay between topology, geometry, and dynamics. Simplicial complexes are higher-order networks that encode higher-order topology and dynamics of complex systems. Specifically, simplicial complexes can sustain topological signals, i.