Functional neuroimaging for addiction medicine: From mechanisms to practical considerations.

During last 20 years, neuroimaging with functional magnetic resonance imaging (fMRI) in people with drug addictions has introduced a wide range of quantitative biomarkers from brain's regional or network level activities during different cognitive functions. These quantitative biomarkers could be potentially used for assessment, planning, prediction, and monitoring for "addiction medicine" during screening, acute intoxication, admission to a program, completion of an acute program, admission to a long-term program, and postgraduation follow-up. In this chapter, we have briefly reviewed main neurocognitive targets for fMRI studies associated with addictive behaviors, main study types using fMRI among drug dependents, and potential applications for fMRI in addiction medicine.

Spelling Acquisition in English and Italian: A Cross-Linguistic Study.

We examined the spelling acquisition in children up to late primary school of a consistent orthography (Italian) and an inconsistent orthography (English). The effects of frequency, lexicality, length, and regularity in modulating spelling performance of the two groups were examined. English and Italian children were matched for both chronological age and number of years of schooling.

Why language really is not a communication system: a cognitive view of language evolution.

While most evolutionary scenarios for language see it as a communication system with consequences on the language-ready brain, there are major difficulties for such a view. First, language has a core combination of features-semanticity, discrete infinity, and decoupling-that makes it unique among communication systems and that raise deep problems for the view that it evolved for communication. Second, extant models of communication systems-the code model of communication (Millikan, 2005) and the ostensive model of communication (Scott-Phillips, 2015) cannot account for language evolution.

Non-invasive Human Brain Stimulation in Cognitive Neuroscience: A Primer.

The use of non-invasive brain stimulation is widespread in studies of human cognitive neuroscience. This has led to some genuine advances in understanding perception and cognition, and has raised some hopes of applying the knowledge in clinical contexts. There are now several forms of stimulation, the ability to combine these with other methods, and ethical questions that are special to brain stimulation.

Concurrent Validity of the Behavior Rating Inventory of Executive Function in Children With Attention Deficit Hyperactivity Disorder.

Background: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder in which impairment of executive functions plays an important role.

Objectives: The main objective of this study was to assess the validity of the Behavior Rating Inventory of Executive Function (BRIEF) in children with ADHD.

Patients And Methods: Thirty children, aged 7-12 years, attending the child and adolescent clinic of Roozbeh hospital and diagnosed with ADHD according to interview with a child and adolescent psychiatrist, formed our ADHD group.

Decoupling, situated cognition and immersion in art.

Situated cognition seems incompatible with strong decoupling, where representations are deployed in the absence of their targets and are not oriented toward physical action. Yet, in art consumption, the epitome of a strongly decoupled cognitive process, the artwork is a physical part of the environment and partly controls the perception of its target by the audience, leading to immersion. Hence, art consumption combines strong decoupling with situated cognition.

Stress affects articulatory planning in reading aloud.

Three experiments of pseudoword reading assessed whether stress assignment affects reading aloud at the level of articulation planning. In Experiment 1 (immediate reading) both stimulus length (in syllables) and stress type affected reading latency and accuracy. Italian pseudowords were named faster and more accurately when they were assigned stress on the antepenultimate rather than on the penultimate syllable.

List context effects in languages with opaque and transparent orthographies: a challenge for models of reading.

This paper offers a review of data which show that reading is a flexible and dynamic process and that readers can exert strategic control over it. Two main hypotheses on the control of reading processes have been suggested: the route de-emphasis hypothesis and the time-criterion hypothesis. According to the former, the presence of irregular words in the list might lead to an attenuation of the non-lexical process, while the presence of non-words could trigger a de-emphasis of the lexical route.

Patterns of brain activation during craving in heroin dependents successfully treated by methadone maintenance and abstinence-based treatments.

Objective: Abstinence-based therapy (ABT) and methadone maintenance therapy (MMT) are common methods of treatment in heroin dependence as both suppress subjective feeling of drug craving. However, it is not clear whether the neural basis of craving suppression is similar in both types of treatments. In this study, we compared brain activation during pictorial presentation of heroin-related cues in ABT and MMT groups to understand the neural basis of drug craving in these groups.

Interactions between visual and semantic processing during object recognition revealed by modulatory effects of age of acquisition.

The age of acquisition (AoA) of objects and their names is a powerful determinant of processing speed in adulthood, with early-acquired objects being recognized and named faster than late-acquired objects. Previous research using fMRI (Ellis et al., 2006.

Stress assignment in reading Italian: friendship outweighs dominance.

Stress assignment to polysyllabic words is the only aspect of the pronunciation of written Italian that cannot be predicted by rule. It could be a function of stress dominance in the language or of stress neighborhood (i.e.

Treatment outcome predictors in flexible dose-duration methadone detoxification program.

Methadone detoxification is among the widely used treatment programs for opioid dependence. The aims of this study were to identify which patient baseline factors and treatment regimen features are predictors of the treatment outcome in an outpatient flexible dose-duration methadone detoxification program.  We studied 126 opioid dependents in a naturalistic nonexperimental clinical setting.

The polarity-dependent effects of the bilateral brain stimulation on working memory.

Introduction: Working memory plays a critical role in cognitive processes which are central to our daily life. Neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (DLFPC). This study was aimed to assess whether bilateral modulation of the DLPFC using a noninvasive brain stimulation, namely transcranial direct current stimulation (tDCS), modifies the working memory function in healthy adults.

Functional segmentation of the hippocampus in the healthy human brain and in Alzheimer's disease.

In this study we segment the hippocampus according to functional connectivity assessed from resting state functional magnetic resonance images in healthy subjects and in patients with Alzheimer's disease (AD). We recorded the resting FMRI signal from 16 patients and 22 controls. We used seed-based functional correlation analyses to calculate partial correlations of all voxels in the hippocampus relative to characteristic regional signal changes in the thalamus, the prefrontal cortex (PFC) and the posterior cingulate cortex (PCC), while controlling for ventricular CSF and white matter signals.

List context manipulation reveals orthographic deficits in Italian readers with developmental dyslexia.

We tested the influence of list context on word frequency and length effects on the reading aloud of Italian developmental dyslexics and skilled peers. The stimuli were presented either in mixed blocks (alternating words and nonwords) or in pure blocks. The analyses based on the rate-and-amount model ( Faust et al.

A capuchin monkey (Cebus apella) uses video to find food.

We examined the ability of capuchin monkeys to use video without immediate visual-kinaesthetic feedback as a source of information to guide their action in the 3-dimensional world. In experiment 1, 2 capuchins learned to retrieve food under 1 of 2 different objects in 1 cage after watching the experimenter hiding food under 1 of 2 replica objects while in another cage. Information space and retrieval space were thus separate.

Dopamine receptors in human peripheral blood lymphocytes: changes in mRNA expression in opioid addiction.

Gradual adaptations of the brain to repeated drug exposure may induce addiction. Brain mesolimbic dopaminergic pathway is the site of the effect of addictive drugs. The dopamine receptors in peripheral blood lymphocytes may reflect the status of homologous brain receptors.

Morpheme-based reading aloud: evidence from dyslexic and skilled Italian readers.

The role of morphology in reading aloud was examined measuring naming latencies to pseudowords and words composed of morphemes (roots and derivational suffixes) and corresponding simple pseudowords and words. Three groups of Italian children of different ages and reading abilities, including dyslexic children, as well as one group of adult readers participated in the study. All four groups read faster and more accurately pseudowords composed of root and suffix than simple pseudowords (Experiment 1).

Language in Italian children with Down syndrome and with specific language impairment.

This article compares lexical and grammatical abilities of a mental-age-matched sample of Italian preschoolers with Down syndrome (DS), specific language impairment (SLI), or typical development. Results showed that the children with DS or with SLI performed significantly worse than did the typically developing children. Although no significant differences emerged in lexical abilities and morphosyntactic comprehension abilities between the children with DS or with SLI, significant differences did emerge in morphosyntactic production capacities.

What causes the effect of age of acquisition in lexical processing?

Three hypotheses for effects of age of acquisition (AoA) in lexical processing are compared: the cumulative frequency hypothesis (frequency and AoA both influence the number of encounters with a word, which influences processing speed), the semantic hypothesis (early-acquired words are processed faster because they are more central in the semantic network), and the neural network model (early-acquired words are faster because they are acquired when a network has maximum plasticity). In a regression study of lexical decision (LD) and semantic categorization (SC) in Italian and Dutch, contrary to the cumulative frequency hypothesis, AoA coefficients were larger than frequency coefficients, and, contrary to the semantic hypothesis, the effect of AoA was not larger in SC than in LD. The neural network model was supported.

Sense of motor effort in patients with schizophrenia.

We tested the hypothesis suggesting that internally generated signals related to motor command would not be processed in schizophrenic patients with first rank symptoms (FRS). To address this question, we investigated an aspect of the efference copy not yet investigated in schizophrenia, namely its implication in sensation of effort. We assessed sensation of effort in healthy subjects (n = 17) and in schizophrenic patients with (n = 6) and without (n = 11) FRS using two tasks.

Orthographic complexity and word naming in Italian: some words are more transparent than others.

Italian is a language with a transparent orthography in which printed words can be translated into the correct sequence of phonemes using a limited set of rules. The rules of letter-sound conversion are, however, simpler for some letters than for others: The pronunciations of sequences involving the letters c and g are determined by complex (i.e.