[Decellularized cadaveric human artery for substitution of connective tissue and smooth muscle defects on the example of tunica albuginea of penis (experimental work)].

Aim: To analyze experimentally the outcomes of xenotransplantation (cadaveric artery, decellularized cadaveric artery) for tunica albuginea defects repair.

Material And Methods: The study included 60 chinchilla rabbits. Rabbits underwent local replacement of tunica albuginea.

One-step purification and kinetic properties of the recombinant L-asparaginase from Erwinia carotovora.

ECAR-LANS, the recombinant L-asparaginase from Erwinia carotovora, is a prospective therapeutic enzyme for leukaemia treatment. An efficient and economical scheme was developed for the purification, cloning and expression in Eschericha coli of ECAR-LANS. More than 90% purity, complemented with 72% active enzyme recovery, was achieved with a single chromatographic purification step.

The effect of ethanol consumption on the sensitivity of rat brain monoamine oxidases to the inhibition by pargyline in vivo and in vitro.

The effect of ethanol consumption on the sensitivity of rat brain mitochondrial monoamine oxidases to the inhibition by pargyline in vivo and in vitro was investigated. Administration of pargyline (10 mg/kg, s.c.

[Nonviral gene transfer in vivo in gene therapy].

Recent findings connected with in vivo use of artificial macromolecular complexes (genosomes) for functional gene transfer and delivery are discussed in the paper. Non-viral methods are the most safe for the purpose of human gene delivery. The cationic liposomes containing cholesterol are the most suitable for this purpose, because they possess high biodegradability and stability in blood stream.