3 results match your criteria: "Institute for Anaesthesiology and Intensive Operative Care[Affiliation]"
[The Interaction of miRNA-5p and miRNA-3p with the mRNAs of Orthologous Genes].
Mol Biol (Mosk)
October 2019
Scientific Research Institute of Biology and Biotechnology Problems, al-Farabi Kazakh National University, Almaty, 050040 Kazakhstan.
miRNAs regulate the expression of many genes and are involved in the development of diseases. We studied miRNAs that interact partly or fully complementarily with the 5'UTR, CDS and 3'UTR of mRNAs of target genes. The MirTarget program used in this study allows for the discovery of miRNA binding sites (BS) in the entire nucleotide sequence of the mRNA and for determining the characteristics of the interactions of miRNAs with mRNAs.
View Article and Find Full Text PDFBackground: Normally, one miRNA interacts with the mRNA of one gene. However, there are miRNAs that can bind to many mRNAs, and one mRNA can be the target of many miRNAs. This significantly complicates the study of the properties of miRNAs and their diagnostic and medical applications.
View Article and Find Full Text PDFMuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies.
J Mol Biol
June 2008
Institute for Anaesthesiology and Intensive Operative Care, Medical Faculty Mannheim, Mannheim 68167, Germany.
Article Synopsis
- The study investigates the role of the ubiquitin ligase MuRF1 in muscle-wasting conditions like diabetes and starvation, focusing on its impact on carbohydrate metabolism in skeletal muscle.
- MuRF1-TG mice, which over-express MuRF1 in skeletal muscle, show normal muscle weights and fertility but lower levels of critical glycolysis enzymes, suggesting MuRF1 may influence metabolic processes.
- Results from glucose tolerance tests indicate that MuRF1 expression in muscle enhances insulin secretion and shifts glycogen synthesis from muscle to the liver, illustrating a connection between muscle and hepatic metabolism during metabolic stress.