2 results match your criteria: "Institute de Transplantation Et de Recherche en Transplantation[Affiliation]"
Can immune monitoring help to minimize immunosuppression in kidney transplantation?
Transpl Int
January 2009
INSERM, Institute de Transplantation Et de Recherche en Transplantation, Nantes, France.
Article Synopsis
- Research is focused on minimizing or eliminating the serious side effects of lifelong immunosuppressors used in transplantation.
- The field is shifting from general immunosuppression to personalized therapy, relying on immune monitoring tests to assess individual risk levels.
- Recent technological advancements and large prospective studies are essential for getting these monitoring tests approved for regular clinical use.
Blood T-cell receptor beta chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distribution.
Brain
May 2004
Institut National de la Santé et de la Recherche Médicale Unité 437, Immunointervention dans les Allo- et Xénotransplantations, Institute de Transplantation et de Recherche en Transplantation, CHU Hôtel Dieu, 44093 Nantes, France.
Multiple sclerosis is an inflammatory demyelinating disease of the CNS associated with T cells autoreactive for myelin components. In this study, we analysed the T-cell receptor (TCR) usage of the variable beta (Vbeta) chain transcriptome in the blood of multiple sclerosis patients at various stages of the disease using a global and quantitative comparison of the complementarity-determining region 3 length distribution (CDR3-LD) of transcripts of the 26 Vbeta genes. We investigated 35 patients: 12 with a high risk of multiple sclerosis, 10 with clinically definite multiple sclerosis, 13 with a relapsing-remitting worsening and active multiple sclerosis and 13 healthy individuals.
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