Localization and Tumor Growth Inhibition of I-131-Labeled Monoclonal Antibody ERIC1 in a Subcutaneous Xenograft Model of Small Cell Lung Cancer in SCID Mice.

This study evaluates the efficacy of [I]I-ERIC1 in targeting and inhibiting the growth of SCLC tumors in mice, focusing on tumor accumulation and regression and potential side effects. NCAM-positive NCI-H69 SCLC cells were implanted in CB 17 SCID mice, and [I]I-ERIC1 biokinetics were measured in organs and tissues at four post-injection time points (24, 72, 96, and 120 h). The experimental series compared tumor growth, survival, and changes in blood counts among three treatment groups (1, 2, or 3 MBq) and a control group, with treatments initiated either two or five days post implantation.

Sleep patterns in Metropolitan and Regional areas in Japan: Before and during COVID-19 social restrictions.

Sleep timing is an important output of the circadian system. The COVID-19-mandated social restrictions significantly altered commuting time and sleep duration regionally in Japan. This study aimed to elucidate sleep patterns, especially chronotype and social jetlag (SJL), due to changes in social time pressure through the social restrictions between the Metropolitan and Regional areas in Japan.

Influence of physically demanding occupations on the development of osteoarthritis of the hip: a systematic review.

Background: Hip osteoarthritis (HOA) is a disabling disease affecting around 33 million people worldwide. People of working age and the elderly are at increased risk of developing HOA and the disease is associated with high costs at individual and societal levels due to sick leaves, job loss, total hip replacements and disability pension. This systematic review evaluated the influence of physically demanding occupations on the development of HOA in men.

A 4-year longitudinal study investigating the relationship between flexible school starts and grades.

The mismatch between teenagers' late sleep phase and early school start times results in acute and chronic sleep reductions. This is not only harmful for learning but may reduce career prospects and widen social inequalities. Delaying school start times has been shown to improve sleep at least short-term but whether this translates to better achievement is unresolved.

Sleep improvements on days with later school starts persist after 1 year in a flexible start system.

Early school times fundamentally clash with the late sleep of teenagers. This mismatch results in chronic sleep deprivation posing acute and long-term health risks and impairing students' learning. Despite immediate short-term benefits for sleep, the long-term effects of later starts remain unresolved.

Outdoor daylight exposure and longer sleep promote wellbeing under COVID-19 mandated restrictions.

Light is an important regulator of daily human physiology in providing time-of-day information for the circadian clock to stay synchronised with the 24-hr day. The coronavirus disease 2019 (COVID-19) pandemic led to social restrictions in many countries to prevent virus spreading, restrictions that dramatically altered daily routines and limited outdoor daylight exposure. We previously reported that sleep duration increased, social jetlag decreased, and mid-sleep times delayed during social restrictions (Global Chrono Corona Survey, N = 7,517).

Social jetlag, a novel predictor for high cardiovascular risk in blue-collar workers following permanent atypical work schedules.

Cardiovascular diseases cause >4 million deaths each year in Europe alone. Preventive approaches that do not only consider individual risk factors but their interaction, such as the Systematic COronary Risk Evaluation (SCORE), are recommended by European guidelines. Increased cardiovascular risk is associated with shift-work, surely interacting with the concurrent conditions: disruption of sleep, unhealthy behaviours, and circadian misalignment.

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.

Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 P < 5 × 10), including rs7955964 (FIGNL2/ANKRD33) that increases BP among long sleepers, and rs73493041 (SNORA26/C9orf170) and rs10406644 (KCTD15/LSM14A) that increase BP among short sleepers (P < 5 × 10).

COVID-19-mandated social restrictions unveil the impact of social time pressure on sleep and body clock.

In humans, sleep regulation is tightly linked to social times that assign local time to events, such as school, work, or meals. The impact of these social times, collectively-social time pressure, on sleep has been studied epidemiologically via quantification of the discrepancy between sleep times on workdays and those on work-free days. This discrepancy is known as the social jetlag (SJL).

Vaccine-Preventable Infections in Childcare Workers.

Background: Adequate immunity to so-called childhood diseases can lower the occupational risk of vaccine-preventable infectious diseases in persons who work in day-care centers for children.

Methods: A systematic literature survey was carried out in PubMed and Embase for the period January 2000 to February 2019. Studies on immune status and vaccination status were included.

Aircraft Noise and the Risk of Stroke.

Background: There have been many individual studies on the question whether air- craft noise is a risk factor for stroke, but until now there has not been any summary of the current state of the evidence of adequately high methodological quality.

Methods: In a systematic review and meta-analysis (PROSPERO registry number CRD42013006004), we evaluated the relation between address-based aircraft noise exposure and the incidence of stroke. A systematic literature search was performed in the MEDLINE, EMBASE, and BIOSIS databases including publications up to August 2017.

Substance Use During Imprisonment in Low- and Middle-Income Countries.

Substance use disorders are among the most common health problems of people involved with the criminal justice system. Scaling up addiction services in prisons is a global public health and human rights challenge, especially in poorly resourced countries. We systematically reviewed the prevalence of substance use in prison populations in low- and middle-income countries.

Occupational Strain as a Risk for Hip Osteoarthritis.

Background: Multiple epidemiological studies have revealed an association between occupational physical strain and the risk of developing hip osteoarthritis.

Methods: To determine the association between the lifting and carrying of heavy loads or other physically demanding work and the risk of hip osteoarthritis (HOA) or total hip replacement (THR), we systematically searched the literature for primary studies on the effects of exposure to physical strain and meta-analytically reviewed the results that were amenable to comparisons across studies. We separately assessed studies that had hip pain as an endpoint.

Satisfaction with medical treatment in patients with hand dermatitis - a cross-sectional study.

Background: Despite the significant clinical and economic burden of hand dermatitis, data on patients' satisfaction with treatment and related determining factors are lacking.

Patients And Methods: We performed a cross-sectional study using a standardized survey, including all patients with hand dermatitis treated between 12/2001 and 11/2008 at the Department of Dermatology, TU Dresden. Patients were asked about socio-demographic data, disease characteristics, occupational data, quality of life, treatment satisfaction and their treatment goals.

Interleukin gene polymorphisms in pneumoconiosis.

Inhaled asbestos fibres are known to cause inflammation processes with the result of lung or pleural fibrosis and malignancies. Interleukins (IL), such as IL-1β, IL-6 and IL-10, have various functions in the regulation of the inflammatory response and in proliferative processes after inhalation of silica dust and can, therefore, influence the pathogenesis of asbestos-induced fibrosis and carcinogenesis. Polymorphisms within these genes may be associated with susceptibility to silica and asbestos-induced lung diseases.

Pre-traumatic, trauma- and treatment-related determinants of self-rated health after a severe trauma.

Background: This analysis examines the relationship between different pre-traumatic, trauma and treatment related factors and self-rated health of heavily injured patients after a severe trauma.

Materials & Methods: A written questionnaire was sent to 121 seriously injured patients who were predominantly hurt by traffic or work related accidents and were treated between june 1996 and july 2000 in two hospitals in North Rhine-Westphalia. Information regarding age, gender, education, occupation, income, injury severity, injury of extremities, state anxiety, date of discharge and taking part in a cognitive behavioural intervention were gathered during the inpatient stage, information about self-rated health, patients subjective evaluation of medical treatment outcome and shared decision making with physicians were gathered about four years after trauma.

Reduced patient demands in hospitals and their determinants.

Objectives: The purpose of this study was to analyze the extent to which patients have suppressed their demands during their hospital stay and to examine the factors that determine this reduction in demands.

Methods: The data, which provided the basis for this study, were obtained from a postal survey utilizing the Cologne Patient Questionnaire (CPQ) that was sent to 1,548 patients who had been treated in 1 of 3 hospitals in Germany. The survey itself was conducted within the scope of the research project entitled "Organizational Governance Using Biopsychosocial Codes" (U-BIKE-Studie).

Predicting Health-related Quality of Life of Severely Injured Patients: Sociodemographic, Economic, Trauma, and Hospital Stay-related Determinants.

Introduction: Due to remarkable improvements in emergency and intensive care medicine in the recent past, the mortality rate for severely injured patients is decreasing. Outcome research therefore should no longer focus only on questions of survival, but also on aspects of the quality of life after severe trauma. This study examined the long-term effect of different sociodemographic, economic, trauma, and hospital-related factors on the health-related quality of life (SF-36) of severely injured patients.

How to improve satisfaction with hospital stay of severely injured patients.

Background: In the context of medical quality assurance, patient satisfaction with medical and organisational aspects of health care service is considered to be a relevant outcome of patient surveys after a stay in hospital. Within quality research, it is assumed that assessments of patient satisfaction represent a direct measure of the quality of health care received. Furthermore, there is evidence that satisfied patients demonstrate higher levels of compliance for the course of their treatment and that the probability of successful treatment completion thus considerably increases.