Terbium-Labeled Gold Nanoparticles as Nanoscale Brachytherapy Agents Against Breast Cancer.

Due to their intriguing emission profile, Terbium-161 (Tb) radiopharmaceuticals seem to bring significant advancement in theranostic applications to cancer treatment. The combination of Tb with nanoscale brachytherapy as an approach for cancer treatment is particularly advantageous and promising. Herein, we propose the application of a hybrid nanosystem comprising gold decorated (Au@TADOTAGA) iron oxide nanoflowers as a form of injectable nanobrachytherapy for the local treatment of breast cancer.

Correlation of Solidification Thermal Variables with Microstructure and Hardness in CuMn11Al8Fe3Ni3 Manganese-Aluminum-Bronze Alloy.

The mechanical properties of a final product are directly influenced by the solidification process, chemical composition heterogeneity, and the thermal variables during solidification. This study aims to analyze the influence of solidification thermal variables on the microstructure, hardness, and phase distribution of the CuMn11Al8Fe3Ni3. The alloy was directionally and upward solidified from a temperature of 1250 °C.

Efflux Pumps and Porins Enhance Bacterial Tolerance to Phenolic Compounds by Inhibiting Hydroxyl Radical Generation.

Phenolic compounds are industrially versatile chemicals that have been successfully produced in microbial cell factories. Unfortunately, most phenolic compounds are highly toxic to cells in specific cellular environments or above a particular concentration because they form a complex with iron and promote hydroxyl radical production in Fenton reactions, resulting in the ferroptosis of cells. Here, we demonstrated that overexpression of efflux pumps and porins, including porins LamB and OmpN, and efflux pumps EmrAB, MdtABC, and SrpB, can enhance phloroglucinol (PG) tolerance by inhibiting the generation of hydroxyl radicals.

Autonomous Defense Based on Biogenic Nanoparticle Formation in Daunomycin-Producing .

Daunomycin is a chemotherapeutic agent widely used for the treatment of leukemia, but its toxicity toward healthy dividing cells limits its clinical use and its production by fermentation. Herein, we describe the development of a specialized cultivation medium for daunomycin production, including a shift to oil rather than sugar as the primary carbon source. This achieved an almost threefold increase in daunomycin yields, reaching 5.

Role of Environmental Factors in Legume- Symbiosis: A Review.

Legumes play a pivotal role in addressing global challenges of food and nutrition security by offering a sustainable source of protein and bioactive compounds. The capacity of legumes to establish symbiotic relationships with rhizobia bacteria enables biological nitrogen fixation (BNF), reducing the dependence on chemical fertilizers while enhancing soil health. However, the efficiency of this symbiosis is significantly influenced by environmental factors, such as soil acidity, salinity, temperature, moisture content, light intensity, and nutrient availability.

Relieving Effect of Extract on DSS-Induced Colitis by Regulating Immunity, Antioxidant Function, Gut Microbiota, and Bile Acid Metabolism in Mice.

, a traditional Chinese herbal medicine, possesses antibacterial, antiviral, and anti-inflammatory properties. The aim of this experiment was to investigate the therapeutic effect of extraction (AOE) in treating colitis induced by dextran sulfate sodium (DSS) in mice. The in vitro antioxidant activity of AOE was evaluated by assessing its iron reduction capacity and scavenging capacity towards 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radicals (·OH).

New Insights into Aspirin's Anticancer Activity: The Predominant Role of Its Iron-Chelating Antioxidant Metabolites.

Epidemiological studies have suggested that following long-term, low-dose daily aspirin (LTLDA) administration for more than 5 years at 75-100 mg/day, 20-30% of patients (50-80 years old) had a lower risk of developing colorectal cancer (CRC) and about the same proportion in developing iron deficiency anemia (IDA). In cases of IDA, an increase in iron excretion is suspected, which is caused by aspirin chelating metabolites (ACMs): salicylic acid, salicyluric acid, 2,5-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid. The ACMs constitute 70% of the administered aspirin dose and have much longer half-lives than aspirin in blood and tissues.

Lactoferrin Modulates Radiation Response Under Hypoxic Conditions, Possibly Through the Regulation of ROS Production in a Cell Type-Specific Manner.

Lactoferrin (LF) is an iron-binding glycoprotein of the transferrin family and has been suggested to have a variety of biological functions, including anticancer activity. However, the effects of LF and its mechanisms in anticancer therapies, especially in radiotherapy against cancer cells under hypoxic conditions, are not well-determined. In this study, we focused on the molecular mechanisms of LF functions in cells under hypoxic conditions.

Exploring the Mechanisms of Iron Overload-Induced Liver Injury in Rats Based on Transcriptomics and Proteomics.

Iron is a trace element that is indispensable for the growth and development of animals. Excessive iron supplementation may lead to iron overload and elevated reactive oxygen species (ROS) production in animals, causing cellular damage. Nevertheless, the precise mechanism by which iron overload causes cell injury remains to be fully elucidated.

Bioprospecting of a Native Plant Growth-Promoting Bacterium B6 for Enhancing Uranium Accumulation by Sudan Grass ( (Piper) Stapf).

Phytoremediation technology is viewed as a potential solution for addressing soil uranium contamination. Sudan grass ( (Piper) Stapf.), noted for its robust root structure and resilience to heavy metals, has garnered significant attention.

Poisoned in their homes - Red blood cell abnormalities in lead-exposed residents of a Pakistani Industrial Zone.

The present study investigated the clinical and hematological effects of chronic lead exposure in the population residing in Shadi Pura, a small industrial zone in Lahore, Pakistan. A cross-sectional analysis of 149 participants recruited through health camps was conducted to explore the hematological manifestations of environmental lead exposure, focusing on various red blood cell (RBC) indices and morphology. Moreover, the study examined the differences in the impact of lead exposure on RBC indices and morphology between men, women, and children.

Preparation of efficient and reusable lanthanum and iron co-modified soda residue for selective phosphate removal from domestic sewage.

The selection of suitable raw materials as adsorbents is a key factor in effectively removing phosphorus from water. As an industrial by-product, soda residue exhibits high porosity and surface area, which can effectively adsorb pollutants. Magnetic lanthanum-iron soda residue (La-Fe-CSR) was synthesized using the co-precipitation method, and its characterization and mechanism for removing phosphate were thoroughly investigated.

siRNA-mediated inhibition of hTERT enhances the effects of curcumin in promoting cell death in precursor-B acute lymphoblastic leukemia cells: an in silico and in vitro study.

This study investigates the interrelationship between human telomerase reverse transcriptase (hTERT) and ferroptosis in precursor-B (pre-B) acute lymphoblastic leukemia (ALL), specifically examining how hTERT modulation affects ferroptotic cell death pathways. Given that hTERT overexpression characterizes various cancer phenotypes and elevated telomerase activity is observed in early-stage and relapsed ALL, we investigated the molecular mechanisms linking hTERT regulation and ferroptosis in leukemia cells. The experimental design employed Nalm-6 and REH cell lines under three distinct conditions: curcumin treatment, hTERT siRNA knockdown, and their combination.

Dynamic soil columns simulate Arctic redox biogeochemistry and carbon release during changes in water saturation.

Thawing Arctic permafrost can induce hydrologic change and alter redox conditions, shifting the balance of soil organic matter (SOM) decomposition. There remains uncertainty about how soil saturation and redox transitions impact dissolved and gas phase carbon fluxes, and efforts to link hydrobiogeochemical processes to ecosystem-scale models are limited. This study evaluates SOM decomposition of Arctic tundra soils using column experiments, water chemistry measurements, microbial community analysis, and a PFLOTRAN reactive transport model.

Biogeochemical mechanisms of zero-valent iron and biochar for synergistically mitigating antimony uptake in rice.

Antimony (Sb) contamination in paddy fields can lead to its accumulation in rice grains, posing a threat to food safety. To address this issue, the combined use of zero-valent iron (ZVI) and biochar (BC) were applied to decrease the uptake of Sb in Sb-polluted soils, and their effects on Sb uptake from soil to rice grains were investigated. Our results showed that the combination treatment of 0.

In situ arsenic immobilization by natural iron (oxyhydr)oxide precipitates in As-contaminated groundwater irrigation canals.

Arsenic-contaminated groundwater is widely used in agriculture. To meet the increasing demand for safe water in agriculture, an efficient and cost-effective method for As removal from groundwater is urgently needed. We hypothesized that Fe (oxyhydr)oxide (FeOOH) minerals precipitated in situ from indigenous Fe in groundwater may immobilize As, providing a solution for safely using As-contaminated groundwater in irrigation.

Characteristics and environmental significance of sulfur isotope signatures in the water environment of typical pyrite mines.

Contaminants in the water environment of different pyrite mines have varying characteristics due to different geological origins. Sulfur isotope (δS) is an effective tool to reveal the mechanism of water environment contamination, but no investigations have yet analyzed the characteristics and environmental significance of the δS in the water environment of different pyrite mines. This study involved a field investigation of four typical pyrite mines in China (representing volcanic, skarn, sedimentary-metamorphic, and coal-deposited types) and the analysis of the hydrochemistry of aqueous samples and the δS of both pyrite and dissolved sulfates.

Advanced flame-retardant biocomposites: Polylactic acid reinforced with green gallic acid‑iron‑phosphorus coated flax fibers.

This study introduces a sustainable approach for enhancing the fire retardancy and smoke suppression of poly(lactic acid) (PLA) composites, contributing to addressing one of the major challenges in biocomposites that limits their application in various engineering fields, as automotive and construction sectors. Flax fibers (FF) were surface functionalized with a novel organic-inorganic hybrid flame retardant (FR), offering a sustainable bioinspired approach that mitigates potential mechanical properties impairment and FR leaching, which can cause environmental concerns and reduced composite durability. The process involves a three-step coating procedure.

Efficacy of bentonite/iron-coated sand as a sediment stabilizer in controlling cadmium, lead, zinc, and arsenic release determined using the diffusive gradients in thin film technology.

In this study, we investigated the efficiency of a bentonite/iron-coated sand (B/ICS) stabilizer in reducing the mobility and accumulation of heavy metals (Pb, Cd, Zn, and As) in contaminated sediments. Bentonite is effective in the adsorption of heavy metals, while ICS is effective in the adsorption of As. When combined, the stabilizer can be applied to mixed-contaminated sediments containing both heavy metals and As.

Synthesis mechanisms, property characterization, and environmental applications of biogenic FeS: A review.

Iron sulfide (FeS) exhibits superior reactivity toward a wide range of contaminants, making it a promising candidate for environmental remediation in various media, including surface water, wastewater, soil, and groundwater. Driven by green and sustainable development principles, efficient, low-cost, and environmentally friendly biosynthesis has attracted considerable attention and has great environmental remediation potential. This review provides a comprehensive overview of the recent advances in biogenic FeS (bio-FeS), focusing on its synthesis mechanisms, performance characterization, and environmental applications.

Tracing the electron transfer behavior driven by hydrophyte-derived carbon materials empowered autotrophic denitrification in iron-based constructed wetlands: Efficacy and enhancement mechanism.

Iron-based constructed wetlands (ICWs) displayed great potential in deep nitrogen elimination for low-polluted wastewater. However, the unsatisfactory denitrification performance caused by the limited solubility and sluggish activity of iron substrates needs to be improved in an eco-effective manner. To fill this gap, the bioavailability of iron substrates (iron scraps) affected by wetland biomass-derived carbon materials with potential conductivity were explored.

Extracellular electron shuttles induced transformation and mobilization of Fe/As with the occurrence of biogenic vivianite.

Microorganisms that utilize organic matter to reduce Fe oxides/hydroxides constitute the primary geochemical processes controlling the formation of high-arsenic (As) groundwater. Biogenic secondary iron minerals play a significant role in As migration. However, the influence of quinone electron shuttles and competitive anionic phosphate on this process has not been thoroughly studied.

Diverse and highly differentiated lava suite in Jezero crater, Mars: Constraints on intracrustal magmatism revealed by Mars 2020 PIXL.

The Jezero crater floor features a suite of related, iron-rich lavas that were examined and sampled by the Mars 2020 rover Perseverance, and whose textures, minerals, and compositions were characterized by the Planetary Instrument for X-ray Lithochemistry (PIXL). This suite, known as the Máaz formation (fm), includes dark-toned basaltic/trachy-basaltic rocks with intergrown pyroxene, plagioclase feldspar, and altered olivine and overlying trachy-andesitic lava with reversely zoned plagioclase phenocrysts in a K-rich groundmass. Feldspar thermal disequilibrium textures indicate that they were carried from their crustal staging area.

Characterization and quantification of iron species in the banded iron formations (BIFs) in China Craton to explore the potential for H2 production using XRD and Mössbauer spectroscopy.

Banded iron formations (BIFs), significant iron ore deposits formed approximately 2.3 billion years ago under low-oxygen conditions, have recently gained attention as potential geological sources for evaluating hydrogen (H₂) production. BIFs are characterized by high concentrations of iron oxide (20 to 40 wt.

Development and nutritional evaluation of pomegranate peel enriched bars.

Pomegranate peel powder is used as a functional ingredient in the development of nutritional bars. Pomegranate (Punica granatum) is well known fruit belongs to punicaceae family having multiple health benefits, not only limited to its edible parts but also in its non-edible parts mostly the peel. Fruit wastes are rich source of nutrients, and can be used for the development of functional food products.