APOE does not predict poor outcome 1 year after ischemic stroke.

Objectives: The apolipoprotein E gene (APOE) polymorphism may influence outcome in various forms of brain injury. The association between APOE genotype and long-term ischemic stroke (IS) outcome is controversial. We have examined the effect of stroke risk factors, clinical status at admission and APOE genotype on survival and dependency 1 year after IS.

Animal model of ethanol abuse: rats selectively bred for high and low voluntary alcohol intake.

The selectively bred alcohol-preferring and alcohol-non-preferring lines of rats have been used to study the biology of alcohol abuse and dependence. In our laboratory new lines of Wistar rats have been selectively outbread for 7 years and 19 generations for high and low ethanol intake (WHP--Warsaw High Preferring) and WLP--Warsaw Low Preferring respectively). After the first selection procedure, the highest scoring females and males were used initiate upward selection, while the lowest scoring pairs were used to initiate downward selection.