The therapeutic potential of Honeysuckle in cardiovascular disease: an anti-inflammatory intervention strategy.

Honeysuckle is a conventional Chinese medicine with several therapeutic applications. With the advancement of modern scientific technologies, Honeysuckle's pharmacological effects and medicinal properties have been investigated more thoroughly. Studies demonstrate that the bioactive compounds in Honeysuckle possess anti-inflammatory effects via several mechanisms, protecting the cardiovascular system.

Shenlian Decoction Ameliorates LPS-Related Inflammation in db/db Mice: Coupling Network Pharmacology With Experimental Verification.

Shenlian (SL) decoction, a renowned traditional Chinese formula for diabetes mellitus, has also been employed to treat intestinal disorders. Previous studies have demonstrated the efficacy of SL decoction in regulating blood glucose and intestinal bacteria. Nevertheless, further analysis is required to elucidate the mechanistic link between SL decoction-mediated improvement of intestinal function and treatment of Type 2 diabetes mellitus (T2DM).

[Biological essence of blood stasis-heat syndrome in ischemic stroke and current research status of traditional Chinese medicine prevention and treatment based on thromboinflammation reaction].

Blood stasis-heat syndrome is one of the common syndromes of ischemic stroke, which is manifested as syndromes of blood stasis and heat during the pathological progression of patients with ischemic stroke, but there is a lack of systematic research on its biological essence. Thromboinflammation reaction is a newly proposed pathological mechanism highly associated with thrombosis and inflammatory reaction, and it refers to the fact that under the mediation of von Willebrand factor(vWF) and the kallikrein-kinin system, thrombosis and inflammatory reaction interact with each other. Activation of T cells and neutrophils further aggravates thrombosis and worsens the pathological progression of ischemic stroke.

Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice.

Following prolonged exposure to hypoxic conditions, for example, due to ascent to high altitude, aging or stroke, cognitive deficits can develop. The exact nature and genesis of hypoxia-induced cognitive deficits remain unresolved. Curcumin has been reported to stimulate neurogenesis and reduce neuronal degeneration.

Revealing the Mechanism of Baroni in Depression Treatment Through Integrated Network Pharmacology and Transcriptomic Analysis.

: Baroni (HCB) is a traditional herb for the treatment of depression in China. However, the active constituents and the underlying mechanisms of its antidepressant effects remain unclear. The aim of this study was to identify the bioactive constituents of HCB and elucidate its underlying mechanism for the treatment of depression.

The Mediating Effects of Chronic Diseases in the Relationship Between Adverse Childhood Experiences and Trajectories of Depressive Symptoms in Later Life: A Nationwide Longitudinal Study.

Numerous studies have established a link between adverse childhood experiences (ACEs) and the development of depression in later life. However, the interactive relationships between ACEs, depression, and chronic diseases are still not well understood. In this study, the aim was to investigate the impact of ACEs on depressive trajectories among middle-aged and elderly individuals in China, as well as to examine the mediating roles of chronic diseases in this association.

JiangyaTongluo decoction ameliorates tubulointerstitial fibrosis via regulating the SIRT1/PGC-1α/mitophagy axis in hypertensive nephropathy.

Introduction: With the increasing prevalence of hypertension, the incidence of kidney diseases is also increasing, resulting in a serious public burden. Jiangya Tongluo decoction (JYTL), a recognized prescription in traditional Chinese medicine (TCM), is commonly used to calm an overactive liver and reduce excess yang, while also promoting blood flow to alleviate obstructions in the meridians. Previous research has indicated that JYTL may help mitigate kidney damage caused by hypertension; however, the underlying mechanisms have not been thoroughly assessed.

[Standard establishment and item list for conducting and reporting rapid review in traditional Chinese medicine].

This study aims to establish the standard items for conducting and reporting rapid review(RR) in traditional Chinese medicine(TCM) and promote the RR transparency in TCM. First, the basic standard items of conducting and reporting RR were reviewed, on the basis of which the basic RR implementation methods and steps were summarized. The initial item pool of RR implementation and reporting standards in TCM was established with the Delphi method.

Antiviral activity of HuaganJiedu decoction (HGJDD) against hepatitis B virus (HBV) through FOXO4/ERK/HNF4α signal pathway.

Ethnopharmacological Relevance: Chronic hepatitis B virus (HBV) infection is still a widespread global health issue. HuaganJiedu Decoction (HGJDD) is a common prescription for treating HBV in China, which has the effect of enhancing antiviral efficacy and improving clinical efficacy. However, its precise mechanism of action remains unclear, warranting further investigation to elucidate its therapeutic potential and integration into standard medical practices.

Recent advancements in traditional Chinese medicine for COVID-19 with comorbidities across various systems: a scoping review.

Background: Traditional Chinese medicine (TCM) has developed a rich theoretical system and practical experience in fighting to infectious diseases over the past thousands of years, and has played an important role in controlling the spread owing to its unique advantages. In particular, its significant contribution to the prevention and control of Corona Virus Disease 2019 (COVID-19) is widely recognized. COVID-19 infection is mainly non-severe with a favorable overall outcome, but patients with comorbidities tend to have a poor prognosis.

Transcriptomic Analysis Reveals the Potential Mechanism of Hook.f. & Thomson in Lowering Serum Uric Acid by Reducing Inflammatory State Through CCR7 Target.

Hook.f. & Thomson (CC) is a traditional medicinal herb with multiple biological activities.

Plant-derived natural compounds for the treatment of acute lung injury: A systematic review of their anti-inflammatory effects in animal models.

Backgrounds And Aims: Acute lung injury (ALI) is a complex pulmonary disease characterized by a severe inflammatory response. The management of ALI presents a formidable challenge due to the intricate nature of its inflammatory cascade. Numerous studies have highlighted the potential therapeutic benefits of plant-derived natural compounds (PNCs) in treating inflammatory diseases.

Hydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage.

Background And Purpose: The field of hydrogen medicine has garnered extensive attention since Professor Ohsawa established that low concentrations of hydrogen (2%-4%) exert antioxidant effects. The present study aimed to evaluate the therapeutic effect of molecular hydrogen in a CUMS rat model.

Methods: A total of 40 SD rats were randomly divided into a control group, a model group, a hydrogen group, and a positive drug group.

Insights and future directions in studying intestinal microbiota post-transjugular intrahepatic portosystemic shunt for hepatitis B virus-related portal hypertension.

The gut microbiota (GM) plays a major role in the progression and treatment response of liver diseases, with diverse compositions based on different etiologies. In China, hepatitis B virus (HBV) infection is the leading cause of cirrhosis and affects the GM composition in patients with cirrhosis-related portal hypertension (PH). However, a few studies have been conducted on GM alterations after transjugular intrahepatic portosystemic shunt (TIPS) in patients with HBV-related PH.

Revealing the scientific connotation of compatibility of Chinese medicine medica based on self-assembly technology.

Chinese materia medica (CMM) compatibility is one core content in the theory of Traditional Chinese Medicine (TCM), and elaborating the scientific connotation of CMM compatibility is of great significance to promote the modernization of TCM. Self-assembly is the combination of active ingredients into aggregates through non-covalent bonds, such as hydrogen bonding, electrostatic interactions, ionic interactions, and hydrophobic interactions. The complex properties and special structures of CMM components create the basis for self-assembly.

Continuous Glucose Monitoring: A Transformative Approach to the Detection of Prediabetes.

Prediabetes, as an intermediary stage between normal glucose homeostasis and overt diabetes, affects an estimated 720 million individuals worldwide, highlighting the urgent need for proactive intervention strategies. Continuous glucose monitoring (CGM) emerges as a transformative tool, offering unprecedented insights into glycemic dynamics and facilitating tailored therapeutic interventions. This perspective scores the clinical significance of even slightly elevated fasting blood glucose levels and the critical role of early intervention.

Integrative network pharmacology and multi-omics to study the potential mechanism of Niuhuang Shangqing Pill on acute pharyngitis.

Ethnopharmacological Relevance: Niuhuang Shangqing Pill (NSP) is a renowned Chinese medicine prescription listed in the Chinese Pharmacopoeia (Edition, 2020; volume 1) and is utilized in clinical practice for treating headaches and acute pharyngitis (AP) associated with "Shanghuo". Despite its widespread use, the pharmacological mechanism and bioactive components underlying NSP in treating AP remain unclear.

Aim Of The Study: This study delved into evaluate the alleviation effect of NSP on AP and explore the mechanisms by analyzing multi-omics.

Effects of acupuncture-related treatments on blood lipid levels in patients with coronary heart disease: A comprehensive review and network meta-analysis.

Background: Dyslipidemia is considered a substantial risk factor for coronary heart disease (CHD). Blood lipid levels in patients with CHD influence cardiovascular events. Therefore, it is critical to monitor and control these levels.