568 results match your criteria: "Institute Nacional de Tecnología Industrial[Affiliation]"

Background: Current literature highlights a gap in precise stroke cost data for Latin America. This study measures the real costs associated with acute ischemic stroke care in Latin America using Time-Driven Activity-Based Costing (TDABC). The findings aim to lay a solid foundation for adopting value-based healthcare (VBHC) strategies in the region.

View Article and Find Full Text PDF

Molecular Modeling of Vasodilatory Activity: Unveiling Novel Candidates Through Density Functional Theory, QSAR, and Molecular Dynamics.

Int J Mol Sci

November 2024

Grupo de Investigaciones en Química y Biología, Departamento de Química y Biología, Facultad de Ciencias Básicas, Universidad del Norte, Carrera 51B, Km 5, vía Puerto Colombia, Barranquilla 081007, Colombia.

Cardiovascular diseases (CVD) pose a significant global health challenge, requiring innovative therapeutic strategies. Vasodilators, which are central to vasodilation and blood pressure reduction, play a crucial role in cardiovascular treatment. This study integrates quantitative structure- (QSAR) modeling and molecular dynamics (MD) simulations to predict the biological activity and interactions of vasodilatory compounds with the aim to repurpose drugs already known and estimateing their potential use as vasodilators.

View Article and Find Full Text PDF

The emergence of harmful microorganisms poses a public health challenge. Antimicrobial cotton textiles with semiconductor oxides offer a promising solution to mitigate pathogen spread. Here, we study the physicochemical interactions between copper oxides (CuO) and cellulose in cotton fiber functionalized with these same oxides for antimicrobial properties.

View Article and Find Full Text PDF

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

View Article and Find Full Text PDF

A horizon scan of biological conservation issues for 2025.

Trends Ecol Evol

December 2024

Conservation Science Group, Department of Zoology, Cambridge University, The David Attenborough Building, Pembroke Street, Cambridge, CB2 3QZ, UK.

We discuss the outcomes of our 16th horizon scan of issues that are novel or represent a considerable step-change and have the potential to substantially affect conservation of biological diversity in the coming decade. From an initial 96 topics, our international panel of 32 scientists and practitioners prioritised 15 issues. Technological advances are prominent, including metal and non-metal organic frameworks, deriving rare earth elements from macroalgae, synthetic gene drives in plants, and low-emission cement.

View Article and Find Full Text PDF

Understanding phenology and its regulation is central for the agronomic adaptation of chickpea. We grew 24 chickpea genotypes in 12 environments to analyse: the environmental and genotypic drivers of phenology; associations between phenology and yield; and phenotypes associated with allelic variants of three flowering related candidate loci: CaELF3a; a cluster of three FT genes on chromosome 3; and an orthologue of the floral promoter GIGANTEA on chromosome 4. A simple model with 3 genotype-specific parameters explained the differences in flowering response to daylength.

View Article and Find Full Text PDF

to assess the job satisfaction level, stressors and working conditions of nursing professionals in some Latin American countries during the COVID-19 pandemic. this is a cross-sectional study of nursing professionals working in hospital, primary care, educational, governmental, research, commercial and independent institutions. An online survey was carried out to assess satisfaction with the Font-Roja instrument, sociodemographic characteristics, stress factors and working conditions.

View Article and Find Full Text PDF

Multi-Taxa Responses to Climate Change in the Amazon Forest.

Glob Chang Biol

November 2024

Departamento de Biologia, Universidade Federal Do Amazonas, Manaus, Brazil.

Article Synopsis
  • Tropical biodiversity is facing significant changes due to intensified hydrological cycles, resulting in more severe droughts and wet seasons, which raises concerns about the resilience of ecosystems.
  • A 20-year study in Central Amazonia assessed the impacts of these climate changes on bird, fish, ant, and palm communities, revealing distinct responses where animals were more affected by sudden climate extremes, while palm species showed more stability over time.
  • The research indicated that while the 'insurance effect' helped moderate long-term impacts of climate events on biodiversity, the anticipated 'environmental refugia' did not effectively protect species during extreme weather conditions, highlighting the complex resilience of ecosystems amidst climate change.
View Article and Find Full Text PDF

In today's pharmaceutical landscape, there's an urgent need to develop new drug delivery systems that are appealing and effective in ensuring therapeutic adherence, particularly among paediatric patients. The advent of 3D printing in medicine is revolutionizing this space by enabling the creation of precise, customizable, and visually appealing dosage forms. In this study, we produced 250 mg metformin paediatric gummies based on the semi-solid extrusion (SSE) 3D printing technique.

View Article and Find Full Text PDF

Arrhythmogenic cardiomyopathy (ACM) is a leading cause of sudden cardiac death among young adults. Aberrant gap junction remodeling has been linked to disease-causative mutations in plakophilin-2 (). Although gap junctions are a key therapeutic target, measurement of gap junction function in preclinical disease models is technically challenging.

View Article and Find Full Text PDF
Article Synopsis
  • * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
  • * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
View Article and Find Full Text PDF
Article Synopsis
  • Scientists from 34 labs in 19 countries worked together to measure certain fats (ceramides) in human blood using special techniques.
  • They used both standard methods and their own methods to get very accurate and consistent results.
  • The study helps improve future medical tests and treatments by providing reliable information about these fats in blood samples.
View Article and Find Full Text PDF

Language Statistics at Different Spatial, Temporal, and Grammatical Scales.

Entropy (Basel)

August 2024

Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.

In recent decades, the field of statistical linguistics has made significant strides, which have been fueled by the availability of data. Leveraging Twitter data, this paper explores the English and Spanish languages, investigating their rank diversity across different scales: temporal intervals (ranging from 3 to 96 h), spatial radii (spanning 3 km to over 3000 km), and grammatical word ngrams (ranging from 1-grams to 5-grams). The analysis focuses on word ngrams, examining a time period of 1 year (2014) and eight different countries.

View Article and Find Full Text PDF
Article Synopsis
  • Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
  • In 2021, strokes caused about 7.3 million deaths and were a major cause of health problems, especially in specific regions like Southeast Asia and Oceania.
  • There are differences in stroke risks based on where people live and their age, and some areas actually saw more strokes happening since 2015.
View Article and Find Full Text PDF

Pomegranate ( L.) is considered a functional food due to its polyphenol content that benefits the body. The type of processing the fruit undergoes is important, as this also influences the concentrations of these compounds.

View Article and Find Full Text PDF

The use of plant genetic resources (PGR)-wild relatives, landraces, and isolated breeding gene pools-has had substantial impacts on wheat breeding for resistance to biotic and abiotic stresses, while increasing nutritional value, end-use quality, and grain yield. In the Global South, post-Green Revolution genetic yield gains are generally achieved with minimal additional inputs. As a result, production has increased, and millions of hectares of natural ecosystems have been spared.

View Article and Find Full Text PDF

Aptamer-quantum dots platform for SARS-CoV-2 viral particle detection by fluorescence microscopy.

Int J Biol Macromol

October 2024

National Council for Scientific and Technical Research (CONICET), Argentina; Laboratorio de Materiales Biotecnológicos (LaMaBio), Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, GBEyB, Grupo Vinculado IMBICE-CONICET, Roque Sáenz Peña 352, Buenos Aires B1876BXDl, Argentina. Electronic address:

The virus is the smallest known replicative unit, usually in nanometer-range sizes. The most simple and sensitive detection assay involves molecular amplification of nucleic acids. This work shows a novel, straightforward detection based on the interaction of viral particles with fluorescent nanoconstructs without using enzymatic amplification, washing or separation steps.

View Article and Find Full Text PDF

Condensed tannins from Pinus radiata bark: Extraction and their nanoparticles preparation in water by green method.

Int J Biol Macromol

October 2024

Department of Biological and Animal Science, University of Chile, Santa Rosa 11735, La Pintana, Santiago 8820808, Chile. Electronic address:

This work reports for the first time the production of condensed tannin nanoparticles stable in water via modification with glycine betaine. Pine bark, as a byproduct from the paper industry, was used as a source of condensed tannins of high molecular weight. Different glycine betaine concentrations were tested to produce condensed tannin nanoparticles, and the obtained nanoparticles were subjected to several characterization techniques (Dynamic Light Scattering, Field emission scanning electron microscopy, Zeta potential, Fourier transform infrared spectroscopy-Attenuated total reflectance, thermogravimetric analysis).

View Article and Find Full Text PDF

Regional variation in the role of humidity on city-level heat-related mortality.

PNAS Nexus

August 2024

Department of Civil Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Article Synopsis
  • - The study examines the connection between humidity levels and daily human mortality across 739 cities, highlighting how different heat stress indicators can predict health risks related to extreme heat.
  • - It reveals that air temperature (T) effectively predicts heat-related deaths in cities with strong negative humidity correlations, while cities with weak correlations benefit from using humidity-inclusive heat stress indicators for better predictions.
  • - The research underscores the need for improved heat-health alert systems by identifying regions particularly vulnerable to humid heat, facilitating targeted responses to protect public health.
View Article and Find Full Text PDF

Effects of yeast and exogenous fibrolytic enzyme additives on lamb performance and feed efficiency.

Trop Anim Health Prod

August 2024

Department of Animal Science, Federal University of Bahia, 500 Adhemar de Barros Ave, Ondina, Salvador, Bahia, 40170110, Brazil.

Yeast and fibrolytic enzymes serve as additives incorporated into the nutrition of ruminants to regulate rumen fermentation and increase the digestibility of fiber, thereby enhancing the efficiency of rumen fermentation. Two experiments were conducted to assess the impact of five diets: a control diet without additives, diets with yeast (Saccharomyces cerevisiae) or exogenous fibrolytic enzymes (EFE), and diets with a blend of 0.7yeast + 0.

View Article and Find Full Text PDF

The outcome of a viral infection depends on a complex interplay between the host physiology and the virus, mediated through numerous protein-protein interactions. In a previous study, we used high-throughput yeast two-hybrid (HT-Y2H) to identify proteins in that bind to the proteins encoded by the turnip mosaic virus (TuMV) genome. Furthermore, after experimental evolution of TuMV lineages in plants with mutations in defense-related or proviral genes, most mutations observed in the evolved viruses affected the VPg cistron.

View Article and Find Full Text PDF

Maintaining cleaner and more sustainable ecosystems by mitigating greenhouse gas (GHG) emissions from livestock through dietary manipulation is in demand. This study was aimed to assess the effect of Moringa oleifera seeds and probiotics (Pediococcus acidilactici BX-B122 and Bacillus coagulans BX-B118) as feed supplements on GHG production and fermentation profile from steers and sheep. The treatments included diets containing 0, 6, 12, and 18% of M.

View Article and Find Full Text PDF

The study aimed to assess the effects of different dietary Silybum marianum (SM, milk thistle) powder levels on growth performance, productivity, immunity, small intestine, haemato-biochemical parameters, meat quality, and egg and carcass characteristics of laying quails. The experimental subjects consisted of one hundred and eight 43-day-old quails divided into 3 treatments (0, 0.75, and 1.

View Article and Find Full Text PDF
Article Synopsis
  • The article has been identified as needing a correction regarding its DOI reference.
  • The DOI in question is 10.2196/54281, which suggests it’s linked to a research study or publication.
  • The correction aims to clarify or fix inaccuracies that may affect readers' understanding or citation of the work.
View Article and Find Full Text PDF