118 results match your criteria: "Institut des Hautes Études Scientifiques & Centre National de la Recherche Scientifique[Affiliation]"

Resurgence of Chern-Simons Theory at the Trivial Flat Connection.

Commun Math Phys

December 2024

Institut des Hautes Études Scientifiques, Le Bois-Marie 35 rte de Chartres, 91440 Bures-sur-Yvette, France.

Some years ago, it was conjectured by the first author that the Chern-Simons perturbation theory of a 3-manifold at the trivial flat connection is a resurgent power series. We describe completely the resurgent structure of the above series (including the location of the singularities and their Stokes constants) in the case of a hyperbolic knot complement in terms of an extended square matrix (, )-series whose rows are indexed by the boundary parabolic -flat connections, including the trivial one. We use our extended matrix to describe the Stokes constants of the above series, to define explicitly their Borel transform and to identify it with state-integrals.

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Quasiconformal deformation of the chordal Loewner driving function and first variation of the Loewner energy.

Math Ann

April 2024

Institut des Hautes Études Scientifiques, Bures-sur-Yvette, France.

Article Synopsis
  • The paper introduces a variational formula for the Loewner driving function of a simple chord when subjected to small quasiconformal deformations, particularly focusing on Beltrami coefficients that are not influenced by the chord itself.
  • It presents the first variation of the Loewner energy of a Jordan curve, linking this energy to the Dirichlet energy of its driving function and highlighting its significance in understanding the relationship between Loewner energy and the universal Liouville action.
  • Additionally, it explores how the total mass of loops that interact with the Jordan curve changes under such quasiconformal deformations.
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A novel hypothesis about mechanism of thalidomide action on pattern formation.

Biosystems

December 2024

Institute for Integrative Biology of the Cell (I2BC), CNRS, Université Paris-Sud, Université Paris Saclay, Gif-sur-Yvette, France; Komarov Botanical Institute RAS, St-Petersburg, Russia. Electronic address:

Morphogenesis, the complex process governing the formation of functional living structures, is regulated by a multitude of molecular mechanisms at various levels. While research in recent decades has shed light on many pathways involved in morphogenesis, none singularly accounts for the precise geometric shapes of organisms and their components in space. To bridge this conceptual gap between specific molecular mechanisms and the creation of definitive morphological forms, we have proposed the "epigenetic code hypothesis" in our previous work.

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Sharp metastability transition for two-dimensional bootstrap percolation with symmetric isotropic threshold rules.

Probab Theory Relat Fields

August 2024

Research Unit of Probability, Faculty of Mathematics and Geoinformation, Institute of Statistics and Mathematical Methods in Economics, TU Wien, Wiedner Hauptstraße 8-10, 1040 Vienna, Austria.

Article Synopsis
  • The study focuses on two-dimensional critical bootstrap percolation models, demonstrating that certain models with isotropic threshold rules experience a sharp transition in metastability.
  • This research builds on previous work that examined specific percolation rules, expanding the understanding of when these transitions occur.
  • The paper updates and enhances a draft from 2012 by Alexander Holroyd and the first author, aligning it with modern perspectives in the field.
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Rigorous Holographic Bound on AdS Scale Separation.

Phys Rev Lett

August 2024

Université Paris-Saclay, CNRS, CEA, Institut de Physique Théorique, 91191, Gif-sur-Yvette, France and Institut des Hautes Études Scientifiques, 91440, Bures-sur-Yvette, France.

We give an elementary proof of the following property of unitary, interacting four-dimensional N=2 superconformal field theories: At large central charge c, there exist at least sqrt[c] single-trace, scalar superconformal primary operators with dimensions Δ≲sqrt[c] (suppressing multiplicative logarithmic corrections). This follows from a stronger, more refined bound on the spectral density in terms of the asymptotic growth rate of the central charge. The proof employs known results on the structure of Coulomb branch operators.

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The Loewner Energy via the Renormalised Energy of Moving Frames.

Arch Ration Mech Anal

February 2024

Institut des Hautes Études Scientifiques, Bures-sur-Yvette, France.

We obtain a new formula for the Loewner energy of Jordan curves on the sphere, which is a Kähler potential for the essentially unique Kähler metric on the Weil-Petersson universal Teichmüller space, as the renormalised energy of moving frames on the two domains of the sphere delimited by the given curve.

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Unveiling the Merger Structure of Black Hole Binaries in Generic Planar Orbits.

Phys Rev Lett

March 2024

Departament de Física Quàntica i Astrofísica, Institut de Ciències del Cosmos, Universitat de Barcelona, Martí i Franquès 1, E-08028 Barcelona, Spain.

The precise modeling of binary black hole coalescences in generic planar orbits is a crucial step to disentangle dynamical and isolated binary formation channels through gravitational-wave observations. The merger regime of such coalescences exhibits a significantly higher complexity compared to the quasicircular case, and cannot be readily described through standard parametrizations in terms of eccentricity and anomaly. In the spirit of the effective one body formalism, we build on the study of the test-mass limit, and introduce a new modeling strategy to describe the general-relativistic dynamics of two-body systems in generic orbits.

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Long-Range Order for Critical Book-Ising and Book-Percolation.

Commun Math Phys

November 2023

Department of Mathematics, ETH Zurich, Group 3 HG G 66.5 Rämistrasse 101, 8092 Zurich, Switzerland.

In this paper, we investigate the behaviour of statistical physics models on a book with pages that are isomorphic to half-planes. We show that even for models undergoing a continuous phase transition on , the phase transition becomes discontinuous as soon as the number of pages is sufficiently large. In particular, we prove that the Ising model on a three pages book has a discontinuous phase transition (if one allows oneself to consider large coupling constants along the line on which pages are glued).

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In this Letter, we present the design and performance of the frequency-dependent squeezed vacuum source that will be used for the broadband quantum noise reduction of the Advanced Virgo Plus gravitational-wave detector in the upcoming observation run. The frequency-dependent squeezed field is generated by a phase rotation of a frequency-independent squeezed state through a 285 m long, high-finesse, near-detuned optical resonator. With about 8.

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Fermion Disorder Operator at Gross-Neveu and Deconfined Quantum Criticalities.

Phys Rev Lett

June 2023

Institut für Theoretische Physik und Astrophysik and Würzburg-Dresden Cluster of Excellence ct.qmat, Universität Würzburg, 97074 Würzburg, Germany.

The fermion disorder operator has been shown to reveal the entanglement information in 1D Luttinger liquids and 2D free and interacting Fermi and non-Fermi liquids emerging at quantum critical points (QCPs) [W. Jiang et al., arXiv:2209.

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The bulk-boundary correspondence relates topologically protected edge modes to bulk topological invariants and is well understood for short-range free-fermion chains. Although case studies have considered long-range Hamiltonians whose couplings decay with a power-law exponent α, there has been no systematic study for a free-fermion symmetry class. We introduce a technique for solving gapped, translationally invariant models in the 1D BDI and AIII symmetry classes with α>1, linking together the quantized winding invariant, bulk topological string-order parameters, and a complete solution of the edge modes.

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Inference on autoregulation in gene expression with variance-to-mean ratio.

J Math Biol

May 2023

Simons Center for Geometry and Physics, Stony Brook University, Stony Brook, NY, 11794, USA.

Some genes can promote or repress their own expressions, which is called autoregulation. Although gene regulation is a central topic in biology, autoregulation is much less studied. In general, it is extremely difficult to determine the existence of autoregulation with direct biochemical approaches.

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Using Fano factors to determine certain types of gene autoregulation.

ArXiv

March 2023

Simons Center for Geometry and Physics, Stony Brook University, Stony Brook, New York, United States of America.

The expression of one gene might be regulated by its corresponding protein, which is called autoregulation. Although gene regulation is a central topic in biology, autoregulation is much less studied. In general, it is extremely difficult to determine the existence of autoregulation with direct biochemical approaches.

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Impossibility results about inheritance and order of death.

PLoS One

November 2022

Department of Computational Medicine, University of California, Los Angeles, California, United States of America.

If several relatives died with no will, the order of their deaths could affect the inheritance result. When the order of death is unknown, there are three approaches to determine the inheritance result in this simultaneous death situation: apply an inheritance method that is not affected by the order of death; artificially assign the order of death; stipulate that persons with unknown orders do not inherit each other. The last approach is adopted by the current French Civil Code (denoted as the French Approach).

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In this paper, we provide new proofs of the existence and the condensation of Bethe roots for the Bethe Ansatz equation associated with the six-vertex model with periodic boundary conditions and an arbitrary density of up arrows (per line) in the regime . As an application, we provide a short, fully rigorous computation of the free energy of the six-vertex model on the torus, as well as an asymptotic expansion of the six-vertex partition functions when the density of up arrows approaches 1/2. This latter result is at the base of a number of recent results, in particular the rigorous proof of continuity/discontinuity of the phase transition of the random-cluster model, the localization/delocalization behaviour of the six-vertex height function when and , and the rotational invariance of the six-vertex model and the Fortuin-Kasteleyn percolation.

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The MICROSCOPE mission was designed to test the weak equivalence principle (WEP), stating the equality between the inertial and the gravitational masses, with a precision of 10^{-15} in terms of the Eötvös ratio η. Its experimental test consisted of comparing the accelerations undergone by two collocated test masses of different compositions as they orbited the Earth, by measuring the electrostatic forces required to keep them in equilibrium. This was done with ultrasensitive differential electrostatic accelerometers onboard a drag-free satellite.

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Article Synopsis
  • The study investigates compact binary coalescences with at least one component mass between 0.2 and 1.0 solar masses using data from Advanced LIGO and Advanced Virgo detectors over six months in 2019, but they found no significant gravitational wave candidates.
  • The analysis leads to an upper limit on the merger rate of subsolar binaries ranging from 220 to 24,200 Gpc⁻³ yr⁻¹, based on the detected signals’ false alarm rate.
  • The researchers use these limits to set new constraints on two models for subsolar-mass compact objects: primordial black holes (suggesting they make up less than 6% of dark matter) and
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This paper presents a novel biologically-inspired explore-and-fuse approach to solving a large array of problems. The inspiration comes from Physarum, a unicellular slime mold capable of solving the traveling salesman and Steiner tree problems. Besides exhibiting individual intelligence, Physarum can also share information with other Physarum organisms through fusion.

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Parisi-Sourlas Supersymmetry in Random Field Models.

Phys Rev Lett

July 2022

Laboratoire de Physique de l'Ecole normale supérieure, ENS, Université PSL, CNRS Sorbonne Université, Université de Paris, F-75005 Paris, France.

By the Parisi-Sourlas conjecture, the critical point of a theory with random field (RF) disorder is described by a supersymmeric (SUSY) conformal field theory (CFT), related to a d-2 dimensional CFT without SUSY. Numerical studies indicate that this is true for the RF ϕ^{3} model but not for the RF ϕ^{4} model in d<5 dimensions. Here we argue that the SUSY fixed point is not reached because of new relevant SUSY-breaking interactions.

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Intratumor cellular heterogeneity and non-genetic cell plasticity in tumors pose a recently recognized challenge to cancer treatment. Because of the dispersion of initial cell states within a clonal tumor cell population, a perturbation imparted by a cytocidal drug only kills a fraction of cells. Due to dynamic instability of cellular states the cells not killed are pushed by the treatment into a variety of functional states, including a "stem-like state" that confers resistance to treatment and regenerative capacity.

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Two metrics on rooted unordered trees with labels.

Algorithms Mol Biol

June 2022

Department of Computational Medicine, University of California, Los Angeles, USA.

Background: The early development of a zygote can be mathematically described by a developmental tree. To compare developmental trees of different species, we need to define distances on trees. If children cells after a division are not distinguishable, developmental trees are represented by the space [Formula: see text] of rooted trees with possibly repeated labels, where all vertices are unordered.

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The UV prolate spectrum matches the zeros of zeta.

Proc Natl Acad Sci U S A

May 2022

Department of Mathematics, The Ohio State University, Columbus, OH 43210.

SignificanceWe show that the eigenvalues of the self-adjoint extension (introduced by A.C. in 1998) of the prolate spheroidal operator reproduce the UV behavior of the squares of zeros of the Riemann zeta function, and we construct an isospectral family of Dirac operators whose spectra have the same UV behavior as those zeros.

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Mathematics of life spaces: continuation of the 2018 large dimensions course.

Theory Biosci

June 2022

IHES: Institut des Hautes Etudes Scientifiques, Bures-sur-Yvette, France.

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Inference on the structure of gene regulatory networks.

J Theor Biol

April 2022

Laboratory of Genetics, The Rockefeller University, New York 10065, NY, USA.

In this paper, we conduct theoretical analyses on inferring the structure of gene regulatory networks. Depending on the experimental method and data type, the inference problem is classified into 20 different scenarios. For each scenario, we discuss the problem that with enough data, under what assumptions, what can be inferred about the structure.

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Mutagenic Distinction between the Receptor-Binding and Fusion Subunits of the SARS-CoV-2 Spike Glycoprotein and Its Upshot.

Vaccines (Basel)

December 2021

Institut des Hautes Etudes Scientifiques, 35 Route des Chartres, 91440 Bures-sur-Yvette, France.

We observe that a residue R of the spike glycoprotein of SARS-CoV-2 that has mutated in one or more of the current variants of concern or interest, or under monitoring, rarely participates in a backbone hydrogen bond if R lies in the S1 subunit and usually participates in one if R lies in the S2 subunit. A partial explanation for this based upon free energy is explored as a potentially general principle in the mutagenesis of viral glycoproteins. This observation could help target future vaccine cargos for the evolving coronavirus as well as more generally.

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