1 results match your criteria: "Institut Fédératif de Recherche IFR Circulation and University Paris VII[Affiliation]"
Cyclo-oxygenase-1 and -2 contribution to endothelial dysfunction in ageing.
Br J Pharmacol
October 2000
INSERM U-127, Institut Fédératif de Recherche IFR Circulation and University Paris VII, Hôpital Lariboisière, F-75475 Paris cedex 10, France.
Experiments were designed to investigate the role of cyclo-oxygenase isoforms in endothelial dysfunction in ageing. Aortic rings with endothelium of aged and young (24 vs 4 month-old) Wistar rats, were mounted in organ chambers for the recording of changes in isometric tension. In young rats, acetylcholine (ACh) caused a complete relaxation which was not affected by indomethacin (0.
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