The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and insomnia: study protocol for a randomized clinical trial.

Background: As the primary cause of various preventable illnesses, smoking results in approximately five million premature deaths each year in the US and a multitude of adults living with serious illness. The majority of smokers know the health risks associated with smoking and intend to quit. However, quitting is very difficult partly because of insomnia and stress associated with it.

Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial.

Background: Colorectal cancer (CRC) patients frequently experience sleep disturbances, significantly impacting their quality of life. Cognitive behavioral therapy for insomnia (CBT-I) is considered the first-line treatment but is often complex, costly, and requires highly trained therapists. Behavioral activation (BA), derived from cognitive behavioral therapy (CBT), offers a flexible, simple, and cost-effective alternative.

Genetic correlation and mendelian randomization reveal the impact of sleep traits on urolithiasis risk.

Urolithiasis is a common and recurrent condition in the urological spectrum. Despite various proposed mechanisms, the causal relationship between sleep traits and the risk of urolithiasis remains unclear. We used publicly available genome-wide association study (GWAS) summary data from the UK Biobank and FinnGen to perform a two-sample Mendelian randomization (MR) analysis and genetic correlation analysis, evaluating the causal relationship and genetic correlation between sleep traits (chronotype, getting up in the morning, sleep duration, nap during the day, and insomnia) and urolithiasis (calculus of the kidney and ureter, and calculus of the lower urinary tract).

Effects of exercise on sleep quality in women - A systematic review and meta-analysis.

Objectives: Insomnia affects at least one-third of the global population and is more common in women. Exercise has been reported to improve sleep quality and subsequent use of hypnotics. Therefore, we performed a meta-analysis to assess the effect of exercise on sleep quality in adult women.

The mechanism of different orexin/hypocretin neuronal projections in wakefulness and sleep.

Since the discovery of orexin/hypocretin, numerous studies have accumulated evidence demonstrating its key role in various aspects of neuromodulation, including addiction, motivation, and arousal. This paper focuses on the projection of orexin neurons to specific target brain regions through distinct neural pathways to regulate sleep and arousal. We provide a detailed discussion of the projection mechanisms of orexin neurons to downstream neurons, particularly emphasizing their activation of monoaminergic and cholinergic neurons associated with arousal.

Digital traps: How technology fuels nomophobia and insomnia in Taiwanese college students.

This study investigates the relationship between maladaptive digital technology use, which arises from nomophobia, and insomnia among young adults. It specifically focuses on problematic gaming (PG), problematic social media use (PSMU), and problematic YouTube use (PYTU) as significant forms of digital behavior contributing to this contemporary health concern. Adolescents and young adults, being the first generation raised in a highly digitized environment, encounter unique challenges, including the emergence of behavioral addictions.

Chinese Medicines Treatment for Sleep Disturbance in Breast Cancer Survivors: A Network Meta-Analysis.

Background: Sleep disturbance and insomnia are common adverse events in patients with breast cancer (BC). Traditional Chinese Medicine (TCM) treatment for sleep disturbance includes acupuncture, acupressure, auricular acupressure/auricular acupuncture, and Qigong. However, the specific efficacy of these TCM treatment remains unclear.

Wuling capsule combined with sertraline in the therapy of anxiety and depression with insomnia in adolescents.

Background: The treatment of adolescent patients with anxiety, depression and insomnia is challenging, and there is no ideal treatment method.

Aim: To evaluate the clinical efficacy of Wuling capsule combined with sertraline in the treatment of adolescent anxiety, depression and insomnia.

Methods: Eighty adolescent patients with anxiety, depression with insomnia who were admitted to our hospital from April 1, 2022 to March 30, 2024.

A comparative study of depressive and anxiety symptoms, insomnia, and sleepiness in patients with obstructive sleep apnea, restless legs syndrome, or both (CO-ROSA): preliminary findings from a retrospective study.

Patients with obstructive sleep apnea (OSA), restless legs syndrome (RLS), or both may exhibit varied manifestations of depressive and anxiety symptomatology, reflecting the complex interplay between sleep disturbances, neurotransmitter imbalances, and psychosocial stressors in these often overlapping conditions. The aim of this study was to compare depressive and anxiety symptomatology, insomnia severity, and sleepiness in these conditions. Patients were enrolled and subdivided into those with OSA, RLS, and OSA + RLS.

Effects of Mental Disorders on Fibromyalgia Mediated by Insomnia: A Mendelian Randomization Study.

Background: This study employed Mendelian randomization (MR) analysis to confirm the causal effects of mental disorders on fibromyalgia.

Methods: The summary data for exposures, mediator, and outcome were extracted from the GWAS catalog project, IEU openGWAS project, and Finn biobank database. Significantly associated and independent single-nucleotide polymorphisms (SNPs) meeting the criteria of p < 5×10-8, r2 < 0.

[Expert consensus in clinical application of Bailemian Capsules in treatment of insomnia].

Bailemian Capsules, as a proprietary Chinese medicine suitable for insomnia of Yin deficiency and fire-excess type, is currently widely used in psychosomatic diseases such as short-term insomnia, chronic insomnia, post-stroke insomnia, and insomnia with anxiety and depression, and it has been recommended by a number of consensus/guidelines/paths. Based on expert interviews, questionnaire surveys, and a systematic review of research literature related to Bailemian Capsules, this paper followed the "evidence-based, consensus-oriented, and experience-reliant" principle and fully combined expert experience and patient preferences on the basis of the best available evidence. According to the characteristics of Bailemian Capsules and the actual clinical situation, 7 recommendations and 12 consensuses were made for the treatment of insomnia, chronic insomnia with anxiety and depression, and insomnia of special populations with Bailemian Capsules alone and combined drugs.

Comparative efficacy and safety of Chinese patent medicines for primary insomnia: a systematic review and network meta-analysis of 109 randomized trials.

Ethnopharmacological Relevance: Chinese patent medicine (CPM) is formulated using Chinese herbal medicines as raw materials according to prescribed methods and preparation processes. It is one of the most commonly used complementary and alternative therapies for insomnia in China. Dozens of CPMs have been applied in clinical settings to treat primary insomnia, and ample evidence has proven the efficacy and safety of various CPMs.

Survivorship concerns among posttreatment cancer survivors in South Korea: A secondary analysis of a cross-sectional survey.

Background: Cancer survivors may have a variety of survivorship concerns despite their cancer treatment having ended, with some negatively affecting their health-related quality of life. An in-depth understanding of survivorship concerns is essential for the development of survivorship care programs. However, previous findings have been limited to Western countries, and evidence from Asian countries is lacking.

Targeting sleep quality in acutely traumatized individuals to reduce the risk for PTSD: study protocol for a multicentre randomized clinical trial.

There is a great need for feasible interventions in the initial period after a trauma that minimize the risk of developing a clinically relevant PTSD. The majority of people suffer from severe sleep disorders after a traumatic event. Because sleep is essential for processing emotional memories, we aim to improve sleep quality in acutely traumatized patients to benefit adaptive trauma processing and thereby prevent PTSD development.

Efficient Screening in Obstructive Sleep Apnea Using Sequential Machine Learning Models, Questionnaires, and Pulse Oximetry Signals: Mixed Methods Study.

Background: Obstructive sleep apnea (OSA) is a prevalent sleep disorder characterized by frequent pauses or shallow breathing during sleep. Polysomnography, the gold standard for OSA assessment, is time consuming and labor intensive, thus limiting diagnostic efficiency.

Objective: This study aims to develop 2 sequential machine learning models to efficiently screen and differentiate OSA.

Addiction to smartphones in Arabs is associated with severe depressive symptoms and insomnia: a cross-sectional study.

Addiction to smartphones is a global issue. Mental health disturbance is an emerging factor implicated in smartphone addiction. Whether depressive symptoms and anxiety are implicated in smartphone addiction in developing countries such as Jordan is a nexus that warrants investigation.

Designing work for healthy sleep: A multidimensional, latent transition approach to employee sleep health.

Healthy sleep is essential to employee well-being and productivity, but many modern workers do not obtain adequate sleep. Are technology-related changes to job design (i.e.

Predisposing factors for symptoms of anxiety, depression, and insomnia in university students.

Objectives: to characterize the sociodemographic and psychological aspects of university students who sought psychiatric care at a Student Support Center of a Federal University and to analyze associations between mental health issues and predisposing factors.

Methods: a retrospective analysis of 103 medical records was conducted. The statistical analysis consisted of two steps: a descriptive analysis and a predictive analysis using the Logistic Regression Model.

The Effects of COVID-19 on Anxiety and Depressive Symptoms Among Chinese College Students: Chain Mediation of Three Long COVID-19 Symptoms.

Long COVID has become a public health issue, and anxiety and depressive symptoms have been on the rise among young people since the COVID-19 pandemic. The primary purpose of this study was to survey the status of COVID-19 infection, long COVID, and mental health among Chinese college students after China lifted the dynamic zero-COVID policy on December 7, 2022. The secondary purpose was to explore the mediation effect of long COVID on the relationship between COVID-19 and anxiety and depressive symptoms.

Association of Evening Eating with Sleep Quality and Insomnia among Adults in a Brazilian National Survey.

 To examine the association of evening eating clock time, its elapsed time to the midpoint of sleep (TEM), consumption of caffeine and sugary foods, and reporting dinner as the largest meal with sleep quality indicators and insomnia.  Participants (  = 2,050;18-65y) were part of population-based research, with virtual data collection. Logistic regression models were fitted to assess differences in the ORs(95%CI) of sleep duration < 7 hours, sleep latency > 30 minutes, poor sleep quality, and insomnia (outcomes) with the evening diet-related variables.

Phytoconstituents of as a potential adjunct in the treatment of anxiety disorders: In vivo and in silico approaches.

Traditional plants have played a vital role in civilization and medicine throughout history. , a plant used in South Asian traditional medicine, has various medicinal applications but limited research on its impact on the central nervous system (CNS). This study analyzed the methanolic leaf extract of (MECE) for secondary metabolites and conducted experiments to evaluate the sedative, and anxiolytic effect of MECE on a mice model.