Effects of Succinate-Containing Preparation on Characteristics of Rat Erythrocytes in Exhaustive Swimming with a Load.

We studied the dynamics of the red blood cell composition of Wistar male rats at rest and when swimming with a load (4% body weight) before and after administration of a succinatecontaining preparation (meso-2,3-dimercaptosuccinic acid). In rats receiving the succinatecontaining preparation, a decrease in the number of red blood cells and an increase in their volume and absolute and relative number of reticulocytes were observed at rest in comparison with vivarium control. In rats exposed to exhaustive swimming after preliminary administration of the test preparation (12 h before the test), we observed a decrease in hematocrit and erythrocyte diameter in comparison with the corresponding parameters in rats not treated with the preparation; the level of hemoglobin did not change.