5 results match your criteria: "Inserm U1219 Bordeaux Population Health Research Centre[Affiliation]"
Antipsychotics or Mood Stabilizers in Bipolar Disorder: Towards Evidence-Based Personalised Medicine.
Acta Psychiatr Scand
February 2025
University of Bordeaux, Inserm U1219 Bordeaux Population Health Research Centre, Bordeaux, France.
Assessment of circulating blood lymphocytes in adult patients on rituximab to treat immune thrombocytopenia: Circulating number of NK cells is associated with the response at 6 months.
Br J Haematol
July 2023
Internal Medicine and Infectious Diseases Unit, Haut-Leveque Hospital, University Hospital Centre of Bordeaux, Pessac, France.
Immune thrombocytopenia (ITP) is defined by a low platelet count that can trigger potentially life-threatening haemorrhages. Three-quarters of adult patients exhibit persistent or chronic disease and require second-line treatments. Among these, rituximab, an anti-CD20 antibody, has yielded valuable results, with global responses in 60% of patients at 6 months and complete responses in 30% at 5 years.
View Article and Find Full Text PDFHigh-temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines.
Sci Adv
November 2022
Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
Article Synopsis
- The study explores how mRNA vaccines for COVID-19 trigger immune responses, revealing that the first dose leads to modest immune reactions while the second dose causes stronger interferon and inflammatory responses.
- Blood samples taken at high frequency showed that both doses generated different patterns of interferon responses, indicating variations in immune reaction quality and quantity.
- The findings suggest distinct immune response patterns are associated with COVID-19 severity, emphasizing the importance of closely monitoring immune responses after vaccination.
CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death.
iScience
July 2021
Vaccine Research Institute, Université Paris-Est Créteil, Faculté de Médecine, INSERM U955, Team 16, Hopital Henri Mondor, 51 Av Marechal de Lattre de Tassigny, 94010 Créteil, France.
The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients.
View Article and Find Full Text PDFStatin use and risk of severe bacterial infection in a population living with HIV: prospective cohort study of the ANRS CO3 Aquitaine Cohort 2000-2018.
Clin Microbiol Infect
September 2021
Université de Bordeaux, ISPED, Centre INSERM U1219-Bordeaux Population Health Research Centre, 33000 Bordeaux, France.
Article Synopsis
- Bacterial infections are a significant health issue for individuals living with HIV (PLHIV), and although statins have shown protective effects in other groups, their impact on PLHIV is still debated.
- This study aimed to assess whether statin usage reduces the chances of experiencing a first severe bacterial infection (SBI) in a large cohort of PLHIV from 2000 to 2018.
- The results indicated that statins did not significantly affect the incidence of SBIs or pneumonia among PLHIV over the 18-year follow-up period, suggesting that statins may not offer the protective benefits seen in other populations.