6 results match your criteria: "Inselspital University of Bern Bern[Affiliation]"
Amyloid Transthyretin Cardiomyopathy in Elderly Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation.
J Am Heart Assoc
August 2023
Department of Cardiology, Inselspital Bern University Hospital, University of Bern Bern Switzerland.
Background The prevalence of calcific aortic stenosis and amyloid transthyretin cardiomyopathy (ATTR-CM) increase with age, and they often coexist. The objective was to determine the prevalence of ATTR-CM in patients with severe aortic stenosis and evaluate differences in presentations and outcomes of patients with concomitant ATTR-CM undergoing transcatheter aortic valve implantation. Methods and Results Prospective screening for ATTR-CM with Technetium-3,3-diphosphono-1,2-propanodicarboxylic acid bone scintigraphy was performed in 315 patients referred with severe aortic stenosis between August 2019 and August 2021.
View Article and Find Full Text PDFA novel soft cardiac assist device based on a dielectric elastomer augmented aorta: An in vivo study.
Bioeng Transl Med
March 2023
Integrated Actuators Laboratory (LAI), École polytechnique fédérale de Lausanne (EPFL) Neuchâtel Switzerland.
Although heart transplant is the preferred solution for patients suffering from heart failures, cardiac assist devices remain key substitute therapies. Among them, aortic augmentation using dielectric elastomer actuators (DEAs) might be an alternative technological application for the future. The electrically driven actuator does not require bulky pneumatic elements (such as conventional intra-aortic balloon pumps) and conforms tightly to the aorta thanks to the manufacturing method presented here.
View Article and Find Full Text PDFGadolinium Deposition and the Patient's View on the Problem.
AJNR Am J Neuroradiol
December 2020
Department of Diagnostic, Interventional, and Pediatric Radiology, Inselspital University of Bern Bern, Switzerland.
Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation.
Adv Sci (Weinh)
August 2020
Particles-Biology Interactions, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 Switzerland.
Article Synopsis
- Metal oxide nanoparticles are powerful tools in biomedical applications, but a lack of understanding regarding their interaction with tissues hampers their development as effective nanomedicines.
- This study focuses on complex metal oxide nanoparticle hybrids, specifically cerium oxide and bioglass, using advanced analytical methods to track their distribution in tissues after application.
- The findings reveal that when applied topically, these nanoparticles mainly stay at the application site, are taken up by macrophages, help form apatite, and increase lipid accumulation, highlighting the importance of detailed characterization for designing safer nanomedicine systems.
Emricasan Ameliorates Portal Hypertension and Liver Fibrosis in Cirrhotic Rats Through a Hepatocyte-Mediated Paracrine Mechanism.
Hepatol Commun
July 2019
Liver Vascular Biology Research Group Barcelona Hepatic Hemodynamic Lab, IDIBAPS Biomedical Research Institute Barcelona Spain.
In cirrhosis, liver microvascular dysfunction is a key factor increasing hepatic vascular resistance to portal blood flow, which leads to portal hypertension. De-regulated inflammatory and pro-apoptotic processes due to chronic injury play important roles in the dysfunction of liver sinusoidal cells. The present study aimed at characterizing the effects of the pan-caspase inhibitor emricasan on systemic and hepatic hemodynamics, hepatic cells phenotype, and underlying mechanisms in preclinical models of advanced chronic liver disease.
View Article and Find Full Text PDFStructural brain anomalies in patients with FOXG1 syndrome and in Foxg1+/- mice.
Ann Clin Transl Neurol
April 2019
Objective: FOXG1 syndrome is a rare neurodevelopmental disorder associated with heterozygous variants or chromosomal microaberrations in 14q12. The study aimed at assessing the scope of structural cerebral anomalies revealed by neuroimaging to delineate the genotype and neuroimaging phenotype associations.
Methods: We compiled 34 patients with a heterozygous (likely) pathogenic variant.