Enhanced antioxidant and antimicrobial activities of chitosan/oxidized microcrystalline cellulose blended films with Tribulus terrestris extract for food packaging applications.

Chitosan/oxidized cellulose blended film with Tribulus terrestris (T. terrestris) extract films were successfully produced by casting method. The obtained blend films were characterized by structural, mechanical, optical, permeation, antioxidant, and antimicrobial properties.

Efficacy of Ruxolitinib in the management of chronic GVHD.

Objectives: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for hematological diseases, with success rates improving due to advancements in conditioning regimens and new anti-graft versus host disease (GVHD) drugs. Ruxolitinib, an oral selective Janus kinase (JAK) 1 and 2 inhibitor has been used to mitigate the effects of various inflammatory and myeloproliferative syndromes, given the JAK kinase pathway's central role in cytokine signaling during inflammatory and immune processes. In this study we aimed to assess ruxolitinib's efficacy in patients with chronic GVHD (cGVHD).

Pain Experiences and Coping Methods of Living Liver Donors Experiencing Chronic Pain After Surgery: Qualitative Study.

Background: Living liver donors are known to experience many physical symptoms such as pain in the postoperative period.

Aim: This qualitative study was conducted to examine pain experiences and coping methods of living liver donors experiencing postoperative chronic pain.

Methods: The study sample consisted of 16 living liver donors.

Effectiveness of ibrutinib in the management of chronic GVHD.

Objectives: Chronic graft-versus-host disease (cGVHD) represents a significant adverse event that may ensue following allogeneic hematopoietic stem cell transplantation (Allo-HSCT). In patients resistant to corticosteroids, which is the first-line treatment for cGVHD, ibrutinib is being evaluated as a potential treatment option. In this study, we aimed to share the findings of our multicenter study regarding the outcomes of ibrutinib treatment in patients with corticosteroid-resistant cGVHD who had previously received multiple systemic therapies.

Novel biallelic nonsense mutation in IGHMBP2 gene linked to neuropathy (CMT2S): A comprehensive clinical, genetic and bioinformatic analysis of a Turkish patient with literature review.

Background: Spinal muscular atrophy with respiratory distress type 1 (SMARD1) and Charcot-Marie-Tooth type 2S (CMT2S) typically present before age 10. Genetic factors account for up to 50 % of neuropathies, which often display varied symptoms. Mutations in the IGHMBP2 gene are associated with both CMT2S and SMARD1, resulting in a rare clinical condition marked by axonal neuropathy, spinal muscular atrophy, respiratory distress, and muscle weakness.

Investigation of metabolite profiles of kidney tissues in rats treated with favipiravir drug: An NMR-based metabolomics study.

In response to the urgent need for effective treatments during the rapid spread and high mortality rate of COVID-19, existing drugs were repurposed for potential antiviral effects, including favipiravir, originally designed as an RNA-dependent RNA polymerase inhibitor for influenza. Despite limited antiviral effectiveness against COVID-19, favipiravir has been reported to cause several adverse drug events (ADEs) in the body. Recent studies have shown that favipiravir can damage various tissues in rats.

The Effects of Acupressure and Massage on Pain, Menstrual Symptoms, and Quality of Life in Primary Dysmenorrhea: A Randomized Controlled Trial.

The study was carried out to determine the effects of acupressure and massage on pain severity, menstrual symptoms, and quality of life in patients with primary dysmenorrhea. This randomized controlled trial was conducted between January 2021 and May 2021. The study initially enrolled 309 female students with primary dysmenorrhea studying at a university in the Central Anatolia Region of Türkiye.

Reliability and validity of the community balance and mobility scale in individuals with multiple sclerosis.

Aims: This study aims to evaluate the reliability and validity of the Community Balance and Mobility Scale (CB&M) in people with multiple sclerosis (PwMS).

Methods: A total of 65 PwMS (Expanded Disability Status Scale (EDSS) ≤ 5.5) were included in the study.

Analyzing Spinal Cord Stimulation With Different Electrode Configurations: A Numerical Study.

Spinal cord stimulation (SCS) represents a therapeutic approach for chronic pain management in patients refractory to conventional treatments. By implanting electrodes in the epidural space, SCS aims to mitigate pain transmission to the brain through electrical stimulation, often resulting in sensory perceptions such as paresthesia. This study investigates the influence of electrode configurations on electrical parameters, including current density and electric potential, within the spinal cord environment.

What should be the optimal dose of post-transplantation cyclophosphamide for GVHD prophylaxis in allogeneic stem cell transplantation?

Objectives: In this study, we aimed to compare the engraftment days, graft versus host disease (GVHD) development, relapse and overall survival (OS) rates in patients using variable intensity conditioning regimens with two different post-transplant cyclophosphamide (PTCy) doses for hematological malignancies.

Material And Methods: We retrospectively analyzed 162 patients who have had PTCy at a dose of 25 mg/kg × 2 and 50 mg/kg × 2 between 2018 and 2024. Patients were divided in 2 groups; PTCy dose with 25 mg/kg × 2 (Group 1, n = 45) and PTCy dose with 50 mg/kg × 2 (Group 2, n = 117).

Liver Transplantation for Autoimmune Hepatitis: 20 Years of Tertiary Centre Experience.

We analyzed the frequency of complications and survival rates in patients with autoimmune hepatitis (AIH) who underwent liver transplantation at a high-volume transplant center. Patients who underwent transplantation for AIH at the xxx University Liver Transplantation Institute between January 2002 and December 2021 were included. Patients with a confirmed diagnosis of AIH, without concomitant chronic liver disease, were included in the study.

Consensus on transition care for juvenile idiopathic arthritis: a Delphi study with youth, caregivers, and health professionals.

Background: The field of transitional care for chronic conditions in adolescents, notably juvenile idiopathic arthritis (JIA), is rapidly growing. Transitioning these patients to adult healthcare systems presents significant challenges in practical implementation. Consequently, it would be appropriate for each country to develop a transition program tailored to its specific infrastructure.

Investigating Chemical Composition and Functionality of Lactobacillus acidophilus LA-5 Postbiotics Prepared in Classic and Cheese Whey Media.

This study aimed to characterize two types of postbiotics from Lactobacillus acidophilus LA-5 prepared in De Man, Rogosa, and Sharpe (MRS-Pb) and UF cheese whey (W-Pb). We compared the chemical compositions, functional properties, and toxicities of the prepared probiotics. Assessments included antimicrobial and antioxidant activities, total and individual phenolic compounds, volatile compounds, individual free amino acids, and organic acid contents.

The Relationship Between Palliative Care Nurses' Frequency of Providing Spiritual Care and Their Job Satisfaction: A Cross-Sectional Study.

Objective: This study was conducted to evaluate the relationship between the frequency of spiritual care and job satisfaction of palliative care nurses.

Methods: This study was a cross-sectional type. The study population consisted of nurses working in palliative care units of three hospitals in eastern Turkey.

Earthquake From the Perspectives of Amputee Children and Their Parents/Caregivers: A Phenomenological Study.

Background: Earthquakes cause significant psychological and physical trauma in children, especially when leading to amputations, as they disrupt physical, emotional, and social well-being.

Aim: This study was conducted phenomenologically to explore the experiences of children amputated in the Kahramanmaraş earthquake and their parents/caregivers.

Method: This study was conducted as a phenomenological study with children who were amputated in the Kahramanmaraş earthquake and their parents/caregivers between August and October 2023.

The impact of the "treasure game" on geometric thinking and post-learning mood in first-grade children.

Background: This study aimed to investigate the effect of the motor game "Treasure Game" (TG) on first-grade children's level of geometric thinking and post-learning mood tracking (PLMT).

Methods: The study employed 24 first-grade children aged 6.1 ± 0.

Assessment of the Mandibular Osseous Architecture in Cleft Lip and Palate Using Fractal Dimension Analysis: A Pilot Study.

: Although there has been extensive research on the orofacial morphologic effects of cleft lip and palate (CLP), the effects of CLP on mandibular structures remain largely unknown. The aim of this study was to investigate the trabeculation differences in the mandibular osseous architecture of patients with bilateral CLP (BCLP) and left-sided unilateral CLP (UCLP) using fractal dimension (FD) analysis and to compare these findings with healthy controls without CLP. : A total of 63 patients (27 females, 36 males) with a mean age of 9.

Efficacy and Safety of CT-P13 as First- and Second-Line Treatment in Patients with Ankylosing Spondylitis.

CT-P13 is a biosimilar version of infliximab, a monoclonal antibody. In individuals with ankylosing spondylitis (AS), CT-P13 has been shown to be effective and to have a well-tolerated safety profile. The aim of this study was to evaluate the long-term drug persistence, safety, and efficacy of infliximab biosimilar CT-P13 in patients with AS undergoing first-line (1st-line) and later (≥2nd-line) treatment in clinical practice.

Comparative Morphometric Study of the Occipital Condyle in Class III and Class I Skeletal Malocclusion Patients.

Objectives: Since the formation of skeletal malocclusions is closely linked to general craniofacial development, it is crucial to understand the anatomy and growth patterns of the skull base. This study aimed to assess the morphometry of the occipital condyle (OC) on CBCT scans of Class III skeletal malocclusion subjects and compare the findings with those of skeletal Class I malocclusion subjects.

Methods: A retrospective analysis was performed on CBCT images based on predefined inclusion and exclusion criteria.

Can T1W and T2W Dixon Sequences Replace the Standard MRI Protocol in Diagnosing Sacroiliitis?

This study aims to assess the performances of T1‑weighted (T1W) and T2‑weighted (T2W) Dixon sequences as replacements for the standard magnetic resonance imaging (MRI) protocol for diagnosing active and chronic sacroiliitis. This single‑centre, prospective study included 107 patients who underwent 3 Tesla MRIs. The patients with inflammatory low‑back pain (aged 18-50 years) were included.

Effect of Growth Hormone Treatment on Growth Rates in Patients With Growth Hormone Deficiency, Idiopathic Short Stature, and Small for Gestational Age.

Objective: This study aimed to determine the response to growth hormone (GH) therapy of patients with growth hormone deficiency (GHD), idiopathic short stature (ISS), and small for gestational age (SGA).

Materials And Methods: The data of the 202 children who received GH treatment were analyzed retrospectively. Laboratory parameters, puberty stages, annual growth rates, body mass index (BMI), GH side effects, target height (TH), estimated adult height (EAH), and bone age (BA) were obtained during the GH treatment period.

Cytotoxic and apoptotic potentials of four native apricot varieties from Malatya, Turkey: A comprehensive evaluation.

In recent years, the role of functional foods in addressing various health issues, including cancer, has gained significant attention. Among these, the cytotoxic and apoptotic properties of Malatya apricots hold particular interest for their potential therapeutic benefits. This study focused on exploring the effects of methanol and acetone extracts from four popular Malatya apricot varieties-Hacıhaliloğlu, Hasanbey, Kabaaşı, and Soğancı-on cancer cell lines.

Evaluation of the Effect of Precursor NMC622@TiO Core-Shell Powders Using a Prelithiated Anode from Fig Seeds: Spotlight on Li-ion Full-Cell Performance.

In this study, innovative electrode materials for lithium-ion batteries (LIBs) were developed and characterized, demonstrating significant performance enhancements. Initially, NMC622@TiO was synthesized using a wet-chemical method with titanium(IV) ethoxide as the Ti source. Advanced structural investigations confirmed the successful formation of a core@shell structure with negligible cation mixing (Li/Ni) at the NMC622 surface, contributing to enhanced electrochemical performance.

The role of basic psychological needs satisfaction and subjective well-being in the relationship between identification with all humanity and physical health problems: A serial mediation model.

The present study sought to explore the mediating effects of basic psychological needs satisfaction (BPNS) and subjective well-being (SWB) on the link between identification with all humanity (IWAH) and physical health problem (PHP). The sample consisted of 552 young and middle-aged Turkish adults ( = 29.53 ± 8.