Correlation between sonographic classification and the efficacy of microwave ablation for adenomyosis.

Background: Adenomyosis is a common benign gynecological disease. Patients often experience abnormal uterine bleeding, dysmenorrhea, and infertility. Percutaneous microwave ablation (PMWA) is a minimally invasive method used for treating adenomyosis while preserving the uterus.

Corrigendum: Immune regulation and prognostic prediction model establishment and validation of PSMB6 in lung adenocarcinoma.

[This corrects the article DOI: 10.3389/fgene.2024.

Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7 immunorad conference.

Over the last decade, the annual Immunorad Conference, held under the joint auspicies of Gustave Roussy (Villejuif, France) and the Weill Cornell Medical College (New-York, USA) has aimed at exploring the latest advancements in the fields of tumor immunology and radiotherapy-immunotherapy combinations for the treatment of cancer. Gathering medical oncologists, radiation oncologists, physicians and researchers with esteemed expertise in these fields, the Immunorad Conference bridges the gap between preclinical outcomes and clinical opportunities. Thus, it paves a promising way toward optimizing radiotherapy-immunotherapy combinations and, from a broader perspective, improving therapeutic strategies for patients with cancer.

Prognostic value of immuno-inflammatory biomarkers in esophageal squamous cell carcinoma patients receiving immunotherapy combined with chemoradiotherapy and its association with immuno-genomic landscape.

Background: The clinical significance of immuno-inflammatory indicators and the underlying biological basis in patients with esophageal squamous cell carcinoma (ESCC) who receive chemoradiotherapy (CRT) combined with immunotherapy remains unclear. This study aims to evaluate the prognostic value of immuno-inflammatory biomarkers, develop a prognostic model, and explore the underlying mechanisms.

Methods: This study included 212 ESCC patients who received CRT and anti-PD-1 immunotherapy.

Reducing under-five mortality in Tanzania: insights from a 60-years data analysis on economic and health indicators.

Background: Under-five mortality in Tanzania remains a persistent issue, significantly affecting both the health and economic sectors. Despite various interventions, the under-five mortality rate (U5MR) remains high, impeding progress toward global health targets. This study investigates the factors influencing under-five mortality in Tanzania, focusing on the gross domestic product (GDP), malaria incidence, access to water, and access to sanitation.

Multi-dimensional Dataset of Stress Measurements based on Performance, Behavioural, and Perceptual Indicators.

The role of humans in industry is changing due to the technological transformation of production processes, which represents a potential source of stress for workers. In this context, the NO-STRESS project aims to combine objective and subjective data collected during task execution to explore causes of work-related stress and propose solutions to mitigate them. This paper describes the within-subjects study design used in the project, where each participant was exposed to all experimental conditions, and outlines the workflow developed during the study.

Sardinian deer increase feeding diversity within sheltering vegetation in a fragmented Mediterranean landscape.

This study was carried out to investigate the feeding behavior of Sardinian deer roaming within a site of community interest (SCI, ITB042250), on Sardinian Island (39° 51' N 8° 45' E). Crop fields bordering the natural environment (wood forest and Mediterranean macchia, where the reserve of Sardinian deer partly overlaps) were monitored and turned into a living lab. The interest on wildlife-related crop damage poses a significant economic challenge, while anthropogenic pressures, such as urbanization and agricultural practices, increasingly impact wildlife by limiting habitat, feeding source diversity and access, and space distribution.

Multispecies pasture diet and cow breed affect the functional lipid profile of milk across lactation in a spring-calving dairy system.

This study compared the effect of 2 pasture-based feeding systems, namely a traditional perennial ryegrass (PRG) diet, and a recently introduced, more sustainable multispecies swards (MSS) diet, on the functional lipid profile of raw milk. In addition to the 2 pasture diets, the study uniquely examined the combined effects of breed, namely Holstein Friesian (HF) or Jersey Holstein Friesian (JFX), and lactation stage in Ireland, spanning from March to November. Bulk milk samples (n = 144 yearly) for the 4 groups examined were collected for 4 wk per each of the 9 mo specified.

Comparison of the mid-infrared spectra and prediction equations developed from morning and evening milk samples from twice-a-day milked dairy cows.

Mid-infrared spectroscopy is a technology used globally for quantifying the concentration of fat, protein, lactose, and other constituents in the milk samples of both individual animals and bulk tank milk. Differences in the milk components and yield of cows are known to exist between morning and evening milk; nonetheless, differences in the spectra originating from the same cow from morning and evening milkings have never been investigated. Data were obtained from 2,602 dairy cows from 7 research farms in Ireland.

Differentiating low-carbon waste management strategies for bio-based and biodegradable plastics under various energy decarbonization scenarios.

Bio-based and biodegradable (bio-)plastics are heralded as a key solution to mitigate plastic pollution and reduce CO emissions. Yet, their end-of-life treatments embodies complex energy and material interactions, potentially leading to emissions through incineration or recycling. This study investigates the cradle-to-grave, emphasizing the waste management stage, carbon footprint for several types of bio-plastics, leveraging both GWP100a and CO uptake methods to explore the carbon reduction benefits of recycling over disposal.

Radiofrequency Ablation Versus Stereotactic Body Radiotherapy for Recurrent Small Hepatocellular Carcinoma: A Randomized, Open-Label, Controlled Trial.

Purpose: To assess the efficacy and safety of radiofrequency ablation (RFA) versus stereotactic body radiotherapy (SBRT) in treating recurrent small hepatocellular carcinoma (HCC).

Methods: In this trial, patients with recurrent small HCC (single lesion ≤5 cm) were randomly assigned to receive either SBRT or RFA. The primary end point was local progression-free survival (LPFS), and secondary end points were progression-free survival (PFS), overall survival (OS), local control rate, and safety.

Effect of pre-farrowing hygiene routine (sub-standard vs. optimal) and creep feeding regime (dry pelleted starter diet vs. liquid mixture of milk replacer and starter diet) on post-weaning intestinal parameters and growth to slaughter in pigs.

The objective was to evaluate the effect of providing a dry pelleted starter diet (DPS) or a liquid mixture of milk replacer and starter diet (LMR + S) to suckling pigs housed in farrowing pens of sub-standard or optimal hygiene conditions on pig growth to slaughter, and post-weaning (PW) intestinal parameters. On day (d) 107 of gestation, 87 sows were randomly allocated to one of four treatments in a 2 × 2 factorial arrangement. The factors were creep feeding (DPS or LMR + S) and pre-farrowing hygiene routine (SUB-STANDARD or OPTIMAL).

The Hansen's baccata #2 gene Rvi12_Cd5 confers scab resistance to the susceptible apple cultivar "Gala Galaxy".

To enhance the breeding of new scab-resistant apple cultivars, a comprehensive understanding of the mechanisms governing major scab resistance genes is essential. Rvi12_Cd5 was previously identified as the best candidate gene for the Rvi12 scab resistance of the crab apple "Hansen's baccata #2" by gene prediction and in silico analysis. In the present study, Rvi12_Cd5 was used to transform the scab-susceptible apple cultivar "Gala Galaxy.

Infrared imaging with visible light in microfluidic devices: the water absorption barrier.

Infrared spectro-microscopy is a powerful technique for analysing chemical maps of cells and tissues for biomedical and clinical applications, yet the strong water absorption in the mid-infrared region is a challenge to overcome, as it overlaps with the spectral fingerprints of biological components. Microfluidic chips offer ultimate control over the water layer thickness and are increasingly used in infrared spectro-microscopy. However, the actual impact of the water layer thickness on the instrument's performance is often left to the experimentalist's intuition and the peculiarities of specific instruments.

Inferring Long-Term and Short-Term Determinants of Genetic Diversity in Honey Bees: Beekeeping Impact and Conservation Strategies.

Bees are vital pollinators in natural and agricultural landscapes around the globe, playing a key role in maintaining flowering plant biodiversity and ensuring food security. Among the honey bee species, the Western honey bee (Apis mellifera) is particularly significant, not only for its extensive crop pollination services but also for producing economically valuable products such as honey. Here, we analyzed whole-genome sequence data from four Apis species to explore how honey bee evolution has shaped current diversity patterns.

Identification of novel germline mutations in FUT7 and EXT1 linked with hereditary multiple exostoses.

Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder primarily linked with mutations in Exostosin-1 (EXT1) and Exostosin-2 (EXT2) genes. However, not all HME cases can be explained by these mutations, and its pathogenic mechanisms are not fully understood. Herein, utilizing whole-exome sequencing and genetic screening with a family trio design, we identify two novel rare mutations co-segregating with HME in a Chinese family, including a nonsense mutation (c.

A Novel Nanoscale Phase-Change Contrast Agent Evaluates the Hepatic Fibrosis Through Targeting Hepatic Stellate Cell Platelet-Derived Factor Beta Receptor by Ultrasound in Vitro.

Objective: As a reversible condition at its early stages, liver fibrosis can progress to cirrhosis and hepatocellular carcinoma, underscoring the importance of early detection for preventing severe outcomes and improving prognosis. To address this issue, we developed a platelet-derived growth factor receptor β (PDGFRβ)-targeted nanoscale phase-change contrast agent to target activated hepatic stellate cells (aHSC) and enable ultrasound imaging as a foundation for the early evaluation of liver fibrosis.

Methods: PDGFR-β antibody-modified phase-change contrast agents (PPCAs) were synthesized utilizing film hydration and ultrasonic emulsification with perfluoropentane (PFP) encapsulated.

Transition cow health and management in pasture-based dairy herds: A farmers' survey.

Seasonal-calving pasture-based systems characterize Irish dairy production. During the dry period, cows are housed and offered predominantly grass silage, providing unique transition cow management opportunities. This study aimed to describe transition period disease incidence and management strategies reported by farmers, and to evaluate their associations with herd size and calving pattern to inform and guide research activities and national advisory.

SASH1 is a novel binding partner to disassemble Caskin1 tandem SAM homopolymer through heterogeneous SAM-SAM interaction.

Calcium/calmodulin-dependent serine protein kinase (CASK) interaction protein 1/2 (Caskin1/2) is essential neuronal synaptic scaffold protein in nervous system development. Knockouts of Caskin1/2 display severe deficits in novelty recognition and spatial memory. The tandem sterile alpha motif (SAM) domains of Caskin1/2, also conserved in their Drosophila homolog Ckn, are known to form homopolymers, yet their dynamic regulation mechanism remains unclear.

Essential oil supplementation improves insulin sensitivity and modulates the plasma metabolome of hyperinsulinemic horses.

The objective of this study was to investigate the effect of essential oil (EO) supplementation on insulin sensitivity (IS) and the plasma metabolome in insulin dysregulated (ID) horses. Horses were blocked by degree of IS and assigned randomly to treatment: oral daily bolus (50 mL) of either a plant derived EO supplement or carrier (CON). Mares were housed in dry lots with access to grass hay and supplemented individually twice daily with a concentrate to meet nutrient requirements for mature horses.

Effects of distiller's dried grains with solubles on enteric methane emissions in dairy and beef cattle: a meta-analysis.

Introduction: Distiller's dried grains with solubles (DDGS), a by-product of grain fermentation for ethanol production, are extensively used in livestock feed. Given their nutrient composition, DDGS could potentially influence methane (CH) emissions, a significant greenhouse gas concern in ruminant production systems. This study utilized a multilevel random-effects meta-analysis to assess the impact of DDGS inclusion in cattle diets on CH production and yield.

Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy.

Four to eight percent of patients with head and neck cancer will develop osteoradionecrosis of the jaw (ORNJ) after radiotherapy. Various radiation-induced tissue injuries are associated with reactive oxygen and nitrogen species (RONS) overproduction. Herein, Fe doping is used in VO (Fe-VO) nanozymes with multienzyme activities for ORNJ treatment via RONS scavenging.

Bioactivated Glucoraphanin Improves Cell Survival, Upregulating Phospho-AKT, and Modulates Genes Involved in DNA Repair in an In Vitro Alzheimer's Disease Model: A Network-Transcriptomic Analysis.

Background/objectives: Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, for which a definitive cure is still missing. Recently, natural compounds have been investigated for their possible neuroprotective role, including the bioactivated product of glucoraphanin (GRA), the sulforaphane (SFN), which is highly rich in cruciferous vegetables. It is known that SFN alleviates neuronal dysfunction, apoptosis, and oxidative stress in the brain.

Enzyme Engineering: Performance Optimization, Novel Sources, and Applications in the Food Industry.

This review summarizes the latest progress in enzyme preparation, including enzyme design and modification technology, exploration of new enzyme sources, and application of enzyme preparation in food processing, detection, and preservation. The directed evolution technology improved the stability and catalytic efficiency of enzymes, while enzyme immobilization technology enhanced reusability and industrial applicability. Extremozymes and biomimetic enzymes exhibit excellent performance under harsh conditions.