Clinical significance of the combined systemic immune-inflammatory index and prognostic nutritional index in predicting the prognosis of patients with extensive-stage small-cell lung cancer receiving immune-combination chemotherapy.

Background: The therapeutic efficacy and prognosis of various tumors can be assessed using the systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI). Despite their potential, no studies have investigated the prognostic value of the combined SII-PNI score for outcomes in patients with extensive small cell lung cancer (ES-SCLC) treated with chemotherapy and immune checkpoint inhibitors (ICIs).

Materials And Methods: Our study retrospectively examined 213 ES-SCLC patients treated with chemotherapy and ICIs across two institutions.

Burden of Hepatocellular Carcinoma and Its Underlying Etiologies in China, 1990-2021: Findings From the Global Burden of Disease Study 2021.

Purpose: The incidence and mortality of hepatocellular carcinoma (HCC) and its underlying etiologies in China are still unclear. Therefore, this study used the Global Burden of Disease (GBD) 2021 to evaluate the incidence and mortality of HCC and its underlying etiologies in China.

Methods: We extracted the incident cases, incidence rate, deaths, and mortality rate of HCC and its underlying etiologies in China in 1990 and 2021 from the GBD database.

Effects of on alcohol-induced liver injury through storing Nrf2/HO-1 pathway and gut microbiota.

Background: L. Sch. Bip.

Association of life's essential 8 with mortalities in patients with alcohol-related liver disease.

Background: Alcohol-related liver disease (ALD) and cardiovascular diseases share some common risk factors. This study aims to investigate the associations between Life's Essential 8 (LE8), a comprehensive measure of cardiovascular health (CVH), and outcomes of ALD.

Methods: Data were obtained from the 2011-2018 National Health and Nutrition Examination Survey (NHANES).

A deep-learning pipeline for the diagnosis and grading of common blinding ophthalmic diseases based on lesion-focused classification model.

Background: Glaucoma (GLAU), Age-related Macular Degeneration (AMD), Retinal Vein Occlusion (RVO), and Diabetic Retinopathy (DR) are common blinding ophthalmic diseases worldwide.

Purpose: This approach is expected to enhance the early detection and treatment of common blinding ophthalmic diseases, contributing to the reduction of individual and economic burdens associated with these conditions.

Methods: We propose an effective deep-learning pipeline that combine both segmentation model and classification model for diagnosis and grading of four common blinding ophthalmic diseases and normal retinal fundus.

Folate intake and the risk of endometrial cancer: A dose-response meta-analysis.

Background: The relationship between folate intake and risk of endometrial cancer (EC) is debatable. The goal of this study was to examine the relationship between folate consumption and EC and then conduct a dose-response analysis in accordance with this.

Methods: Up until February 1, 2024, we conducted a thorough search using PubMed, EMBASE, the Cochrane Library, and Web of Science.

Exploring Health Informatics in the Battle against Drug Addiction: Digital Solutions for the Rising Concern.

Drug addiction is a rising concern globally that has deeply attracted the attention of the healthcare sector. The United States is not an exception, and the drug addiction crisis there is even more serious, with 10% of adults having faced substance use disorder, while around 75% of this number has been reported as not having received any treatment. Surprisingly, there are annually over 70,000 deaths reported as being due to drug overdose.

Automated identification of pesticide mixtures via machine learning analysis of TLC-SERS spectra.

Identification of components in pesticide mixtures has been a major challenge in spectral analysis. In this paper, we assembled monolayer Ag nanoparticles on Thin-layer chromatography (TLC) plates to prepare TLC-Ag substrates with mixture separation and surface-enhanced Raman scattering (SERS) detection. Spectral scans were performed along the longitudinal direction of the TLC-Ag substrate to generate SERS spectra of all target analytes on the TLC plate.

The causal relationship between psoriasis and cancers: a two-sample Mendelian randomization analysis.

Background: Although observational studies suggest a correlation between psoriasis (PS) and cancers, it is still unknown whether this association can replace causal relationships due to the limitations of observational studies. Therefore, we conducted a two-sample Mendelian randomization (MR) analysis to evaluate the causal relationship between PS and cancers.

Methods: PS genetic summary data were obtained from two genome-wide association studies (GWAS).

Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway.

Background: Astaxanthin (AXT) is a keto-carotenoid with a variety of biological functions, including antioxidant and antifibrotic effects. Small airway remodeling is the main pathology of chronic obstructive pulmonary disease (COPD) and is caused by epithelial-to-mesenchymal transition (EMT) and fibroblast differentiation and proliferation. Effective therapies are still lacking.

The Intake of Cruciferous Vegetables and the Risk of Ovarian Cancer: A Systematic Review and Dose-Response Meta-Analysis.

Introduction: The link between cruciferous vegetables (CVs) and ovarian cancer (OC) is still uncertain. This meta-analysis is intended to investigate the association between CV consumption and the risk of OC, as well as to conduct a dose-response analysis to determine the degree of correlation between them.

Methods: We systematically searched PubMed, Web of Science, Embase, and Cochrane Library databases between database creation and October 2023.

Finite element analysis of female pelvic organ prolapse mechanism: current landscape and future opportunities.

The prevalence of pelvic organ prolapse (POP) has been steadily increasing over the years, rendering it a pressing global health concern that significantly impacts women's physical and mental wellbeing as well as their overall quality of life. With the advancement of three-dimensional reconstruction and computer simulation techniques for pelvic floor structures, research on POP has progressively shifted toward a biomechanical focus. Finite element (FE) analysis is an established tool to analyze the biomechanics of complex systems.

Comparative analysis of automated breast volume scanner (ABVS) combined with conventional hand-held ultrasound and mammography in female breast cancer detection.

Objective And Background: This study aimed to compare the diagnostic value of an automated breast volume scanner (ABVS) combined with conventional hand-held ultrasound and mammography in detecting female breast cancer. Early detection is vital in improving patient outcomes for this prevalent disease.

Methods: Seventy-eight suspicious breast lesions from 60 patients were examined between August 2019 and July 2020.

Measurement and analysis of leakage neutron spectra from Lead slab samples with D-T neutrons.

The leakage neutron spectra from three different sizes of Lead samples were measured by a TOF technique at 60° and 120°. The essential characteristic properties of the experimental measurement spectra can be reproduced well by MCNP code simulations with the ENDF/B-VIII.0, CENDL-3.

Predictive value and accuracy of prenatal four-dimensional color ultrasound for fetal abnormal development.

To investigate the value and accuracy of prenatal GE-E10 ultrasound Equipment in predicting fetal abnormal development. 160 pregnant women and women who received prenatal ultrasound examination were selected. Before delivery, all pregnant women were examined by conventional two-dimensional and four-dimensional (4D) ultrasound.

Interfacial Self-Assembly of Surfactant-Free Au Nanoparticles as a Clean Surface-Enhanced Raman Scattering Substrate for Quantitative Detection of As in Combination with Convolutional Neural Networks.

Surface-enhanced Raman scattering (SERS) is a highly sensitive tool in the field of environmental testing. However, the detection and accurate quantification of weakly adsorbed molecules (such as heavy metal ions) remain a challenge. Herein, we combine clean SERS substrates capable of capturing heavy metal ions with convolutional neural network (CNN) algorithm models for quantitative detection of heavy metal ions in solution.

Prevalence of overweight/obesity and related factors in Keerqin District, Tongliao City: A cross-sectional study.

Objective: This study aimed to analyze the prevalence of overweight/obesity and the factors influencing these conditions among 9- to 18-year-old adolescents in Keerqin District of Tongliao City. We explored whether overweight/obesity is accompanied by differences in eating habits, lifestyle, and mental health.

Methods: A cross-sectional survey was administered to 1,736 adolescents in November 2020.

Cruciferous Vegetable Intake and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis.

Introduction: The relationship between cruciferous vegetables and prostate cancer (PCa) risk remains contentious. This study aimed to assess the association between consuming cruciferous vegetables and PCa risk.

Methods: We carried out a systematic search through PubMed, Embase, Web of Science, and the Cochrane Library until September 20, 2022.

The AMPK-dependent inhibition of autophagy plays a crucial role in protecting photoreceptor from photooxidative injury.

Excessive light exposure can potentially cause irreversible damage to the various photoreceptor cells, and this aspect has been considered as an important factor leading to the progression of the different retinal diseases. AMP-activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR) are crucial intracellular signaling hubs involved in the regulation of cellular metabolism, energy homeostasis, cellular growth and autophagy. A number of previous studies have indicated that either AMPK activation or mTOR inhibition can promote autophagy in most cases.

Comparative efficacy and safety of molecular targeted agents combined with transarterial chemoembolization in the treatment of unresectable hepatocellular carcinoma: a network meta-analysis.

Objective: At present, several molecular targeted agents(MTAs) combined with transarterial chemoembolization (TACE) have been employed to treat unresectable hepatocellular carcinoma (HCC). In this meta-analysis, we compared the efficacy and safety of different MTAs combined with TACE to enable effective decision-making for the clinical treatment of unresectable HCC.

Methods: Pubmed, Web of Science, EMBASE, and Cochrane Library were retrieved to evaluate the efficacy and safety of different MTAs combined with TACE in cohort studies and randomized controlled trials.

[Retracted] MicroRNA‑758 inhibits tumorous behavior in tongue squamous cell carcinoma by directly targeting metadherin.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell invasion assay data shown in Fig. 5E were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, several of which have already been retracted. Owing to the fact that the contentious data in the above article had already been published prior to its submission to , the Editor has decided that this paper should be retracted from the Journal.

Mendelian randomization eradicates the causal relationship between educational attainment, household income, and oropharyngeal cancer.

Background: It was reported that educational attainment and household income are associated with oropharyngeal cancer. However, whether such an association is causal is still unknown.

Methods: The Mendelian randomization (MR) design was performed to disentangle their causal relationship.