The Novel Elemene Derivative, OMe-Ph-Elemene, Attenuates Oxidative Phosphorylation and Facilitates Apoptosis by Inducing Intracellular Reactive Oxygen Species.

The incidence and mortality rates of colorectal cancer have been steadily increasing, making it one of the most prevalent cancers globally. Although current chemotherapy drugs have shown some efficacy in treating this disease, their associated side effects necessitate the development of more effective treatments and medications. The clinical application of elemene is widely utilized in tumor treatment; however, its efficacy is hindered by the requirement for high dosage and suboptimal anticancer effects.

Pd-Catalyzed C(sp)-C(sp) Suzuki Coupling and Synthesis of Lumacaftor Using Designed Monophosphine Ligands.

Novel monophosphine ligands and with a C-P ring were designed and synthesized for the efficient Pd-catalyzed C(sp)-C(sp) Suzuki coupling. With 0.5 mol % Pddba and 2 mol % , aryl halides coupled with alkylboronic acids to give the products in up to 99% yield.